Results 41 to 50 of about 9,857 (229)

A CD14‐Targeting In Situ Hydrogel Directs Macrophage Reprogramming to Minimize Scar Formation

Advanced Science, EarlyView.
A CD14‐targeting in situ hydrogel formed from a microbial polysaccharide rapidly remodels the immune microenvironment by reprogramming macrophage polarization, suppressing excessive inflammation, and coordinating tissue regeneration. This multifunctional hydrogel promotes scar‐reduced wound repair through enhanced angiogenesis, collagen remodeling, and
Rui Fang, Simeng Chen, Qiaozhen Liu, Wenwen Ni, Xi Xu, Jianfa Zhang   +5 more
wiley   +1 more source

Androgen-related disorders and hormone therapy for patients with keloids

, 2022
Keloids are a fibroproliferative disorder of the skin and can cause physical discomfort and psychological burden. Apart from local factors such as skin tension and infection, increasing evidence has suggested that systemic endocrine factors also ...
Zhen Gao, Zongan Chen, Xiaoli Wu, Yating Yang, Wei Liu   +4 more
core   +1 more source

Eruptive keloids after chickenpox [PDF]

, 2011
Hypertrophic scars and keloids result from abnormal wound healing in predisposed individuals. They occur within months of cutaneous trauma (surgical wounds, piercing, lacerations) or inflammation (acne, folliculitis, vaccination site).
Antoine Mahé, Nicolas Kluger, Bernard Guillot   +2 more
core   +2 more sources

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

Pediatric keloids: a 6-year retrospective review [PDF]

, 2017
Background/Objectives: Keloids are reportedly rare at the extremes of life. We sought to describe the epidemiology of pediatric keloids seen at the plastic surgery outpatient department of the University College Hospital, Ibadan.
Olawoye, O.A., Michael, A.I., Ademola, S.A., Oluwatosin, O.M., Iyun, A.O., Adebayo, W.   +5 more
core   +1 more source

Keloids [PDF]

JAMA Dermatology, 2021
Jared, Jagdeo, Eva, Kerby, Donald Alexander, Glass   +2 more
openaire   +2 more sources

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

Analysis of subsets and localization of macrophages in skin lesions and peripheral blood of patients with keloids

Heliyon
Keloids are a type of abnormal fibrous proliferation disease of the skin, characterized by local inflammation that lacks clear pathogenesis and satisfactory treatment.
Xinyi Lv, Zhenghao He, Ming Yang, Lu Wang, Siqi Fu   +4 more
doaj   +1 more source

Phase‐Programmed Microneedles Enable Sequential Hydrogen and Quercetin Release for Scar‐Reduced Regeneration of Burn Wounds

Advanced Science, EarlyView.
A phase‐programmed microneedle patch, comprising a poly (lactic‐co‐glycolic acid) (PLGA) shell and a sulfobutylether‐β‐cyclodextrin (SBECD) core, is designed for sequential hydrogen and quercetin release for scar‐reduced regeneration of burn wounds. ABSTRACT Burn wounds complicated by bacterial infection and fibrotic scarring remain a major clinical ...
Yongnian Zeng, Zhigang Chu, Huiyuan Yang, Wen Zhang, Peng Jiang, Jiapeng Lei, Siyu Zhang, Qiongfang Ruan, Shuhua Liu, Wei Li   +9 more
wiley   +1 more source

Keloids: a new challenge for nutrition

, 2010
Keloids are the result of a dysfunctional scarring process that leads to excessive deposition of extracellular matrix in susceptible individuals, causing them physical, psychological, and social discomfort.
Furtado, Fabianne [UNIFESP], Bonatti, Silvilena [UNIFESP], Lydia M Ferreira, Ferreira, Lydia Masako [UNIFESP], Bersch-Ferreira, Ângela Cristine [UNIFESP], Hochman, Bernardo [UNIFESP], Ângela CB Ferreira, Fabianne Furtado, Bernardo Hochman, Silvilena Bonatti   +9 more
core   +1 more source