Results 21 to 30 of about 70,850,632 (188)

HNRNPK is retained in the cytoplasm by Keratin 19 to stabilize target mRNAs [PDF]

, 2022
Abstract Heterogeneous nuclear ribonucleoprotein K (HNRNPK) regulates pre-mRNA processing and long non-coding RNA localization in the nucleus. It was previously shown that shuttling of HNRNPK to the cytoplasm promotes cell proliferation and cancer metastasis. However, the mechanism of HNRNPK cytoplasmic localization, its cytoplasmic RNA
Arwa Fallatah, Dimitrios G. Anastasakis, Amirhossein Manzourolajdad, Pooja Sharma, Xiantao Wang, Alexis Jacob, Sarah Alsharif, Ahmed Elgerbi, Pierre A. Coulombe, Markus Hafner, Byung Min Chung   +10 more
openaire   +1 more source

Keratin 19, a Cancer Stem Cell Marker in Human Hepatocellular Carcinoma [PDF]

Clinical Cancer Research, 2015
Abstract Purpose: Keratin 19 (K19) is a known marker of poor prognosis and invasion in human hepatocellular carcinoma (HCC). However, the relationship between K19 and cancer stem cells (CSCs) is unclear. Here, we determined whether K19 can be used as a new CSC marker and therapeutic target in HCC. Experimental Design:
Takayuki, Kawai, Kentaro, Yasuchika, Takamichi, Ishii, Hokahiro, Katayama, Elena Yukie, Yoshitoshi, Satoshi, Ogiso, Sadahiko, Kita, Katsutaro, Yasuda, Ken, Fukumitsu, Masaki, Mizumoto, Etsuro, Hatano, Shinji, Uemoto   +11 more
openaire   +2 more sources

An Integrative Bioinformatic Analysis for Keratinase Detection in Marine-Derived Streptomyces

Marine Drugs, 2021
Keratinases present promising biotechnological applications, due to their ability to degrade keratin. Streptomyces appears as one of the main sources of these enzymes, but complete genome sequences of keratinolytic bacteria are still limited.
Ricardo Valencia, Valentina González, Agustina Undabarrena, Leonardo Zamora-Leiva, Juan A. Ugalde, Beatriz Cámara   +5 more
doaj   +1 more source

Heterogeneity of Epigenetic and Epithelial Mesenchymal Transition Marks in Hepatocellular Carcinoma with Keratin 19 Proficiency. [PDF]

Liver Cancer, 2019
<b><i>Objective:</i></b> Keratin 19 (K19) expression is a potential predictor of poor prognosis in patients with hepatocellular carcinoma (HCC). To clarify the feature of K19-proficient HCC, we traced epigenetic footprints in cultured cells and clinical materials.
Yokomichi N, Nishida N, Umeda Y, Taniguchi F, Yasui K, Toshima T, Mori Y, Nyuya A, Tanaka T, Yamada T, Yagi T, Fujiwara T, Yamaguchi Y, Goel A, Kudo M, Nagasaka T.   +15 more
europepmc   +4 more sources

Two mechanisms regulate keratin K15 expression in keratinocytes:role of PKC/AP-1 and FOXM1 mediated signalling [PDF]

, 2012
Background: Keratin 15 (K15) is a type I keratin that is used as a marker of stem cells. Its expression is restricted to the basal layer of stratified epithelia, and the bulge in hair follicles.
Ahmad Waseem (155362), Amrita Bose, Ahmad Waseem, Leigh, IM, Waseem, Ahmad, Leigh, Irene M., Hutchison, Iain L., Iain L. Hutchison (155346), Hong Wan, Leigh Irene M., Hutchison, IL, Teh, MT, Iain L Hutchison, Muy-Teck Teh, Wan Hong, Teh, M-T, Wan, Hong, Bose, A, Irene M. Leigh (155355), Teh Muy-Teck, Muy-Teck Teh (155335), Amrita Bose (155329), Bose, Amrita, Wan, H, Waseem Ahmad, Irene M Leigh, Waseem, A, Hong Wan (149928), Hutchison Iain L., Teh, Muy-Teck, Bose Amrita   +30 more
core   +1 more source

Blackcurrant Extract with Phytoestrogen Activity Alleviates Hair Loss in Ovariectomized Rats

Molecules, 2019
Ancocyanin-rich blackcurrant extract (BCE) has phytoestrogen activity; however, its effect on hair follicles is unknown. Additionally, hair loss is known to occur during menopause in women owing to decreased estrogen secretion.
Naoki Nanashima, Kayo Horie
doaj   +1 more source

The molecular genetic analysis of the expanding pachyonychia congenita case collection [PDF]

, 2014
BackgroundPachyonychia congenita (PC) is a rare autosomal dominant keratinizing disorder characterized by severe, painful, palmoplantar keratoderma (PPK) and nail dystrophy, often accompanied by oral leukokeratosis, cysts and follicular keratosis.
Wilson, N. J., Shepherd, A. A., Hansen, C. D., Sprecher, E., Milstone, L. M., McLean, W. H. I., Schwartz, M. E., Al-Asadi, E., Smith, F. J. D., O'Toole, E.   +9 more
core   +1 more source

The Adjuvant Therapy Influence upon Micrometastasis in Bone Marrow Aspiration and Detection of Relapse Rate in Breast Cancer Patients Follow up [PDF]

International Journal of Hematology-Oncology and Stem Cell Research, 2010
"nIntroduction: Breast cancers in the early phase frequently undergo distant metastasis and survival of patients is greatly dependent on distant metastasis.
Mozafar Aznab, Ardeshir Ghavamzadeh, Kamran Alimoghaddam, Seyed Hamidollah Ghaffari, Shahrbanou Roostami   +4 more
doaj   +2 more sources

The Tumor Markers Tpa, Tps, Tpa and Cyfra 21–1 React Differently with the Keratins 8, 18 and 19

The International Journal of Biological Markers, 1994
The commercially available tumor marker tests TPA, TPS, TPA CYK and CYFRA 21–1 react with simple epithelium keratins. From clinical studies it can be deduced that the pattern of keratin recognition must be different for each of these tests.
H. Bodenmüller, F. Donié, M. Kaufmann, D. Banauch   +3 more
doaj   +1 more source

Biofunctional approaches of wool-based keratin for tissue engineering [PDF]

, 2021
The use of bioactive materials has become a standard tool in the arsenal of tissue engineering and regenerative medicine applications. Bioactive materials have gained great attention due to their ability to mimic tissues physically, chemically and ...
Ranjit, Eliza, George, Roy, Hamlet, Stephen, Love, Robert, Sharma, Ajay, Roy George, Stephen Hamlet, Eliza Ranjit, Robert M. Love, Ajay Sharma   +9 more
core   +1 more source