The Type I Keratin 19 Possesses Distinct and Context-dependent Assembly Properties [PDF]
Journal of Biological Chemistry, 1998 Keratins (K), the cytoplasmic intermediate filament (IF) proteins of epithelial cells, are encoded by a multigene family and expressed in a tissue- and differentiation-specific manner. In human skin, keratinocytes of the basal layer of epidermis and the outer root sheath of hair follicles express K5 and K14 as their main keratins. A small subpopulation
J, Fradette +3 more
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Keratin coated titanium as an aid to osseointegration: Physicochemical and mechanical properties
, 2023 Wool-extracted keratin has been shown to promote bone formation in vivo and may therefore be a potential novel bioactive coating material for osseous implants.
Love, Robert M +5 more
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Influences of Desmin and Keratin 19 on Passive Biomechanical Properties of Mouse Skeletal Muscle [PDF]
Journal of Biomedicine and Biotechnology, 2012 In skeletal muscle fibers, forces must be transmitted between the plasma membrane and the intracellular contractile lattice, and within this lattice between adjacent myofibrils. Based on their prevalence, biomechanical properties and localization, desmin and keratin intermediate filaments (IFs) are likely to participate in structural connectivity and ...
Shah, Sameer B. +4 more
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Chicken keratin‐19: Cloning of cDNA and analysis of expression in the chicken embryonic gut [PDF]
Development, Growth & Differentiation, 1997 From many recent studies, it has been argued that keratins (cytokeratins) play important roles in the morphogenesis and differentiation of organ development. To learn the role of keratin in digestive tract development, a cDNA of the chicken homolog of keratin‐19 (GK‐19) was cloned and its expression pattern was analyzed in the digestive tract of ...
K, Sato, S, Yasugi
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Keratin-Templated Synthesis of Metallic Oxide Nanoparticles as MRI Contrast Agents and Drug Carriers
, 2018 Keratin is a family of cysteine-rich structural fibrous proteins abundantly present in skin and skin appendages. Inspired by the template synthesis strategy, in this work, keratin was utilized for the first time as a platform template to synthesize ...
Chen Peng (429537) +4 more
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Heterogeneity of estrogen receptor expression in circulating tumor cells from metastatic breast cancer patients. [PDF]
PLoS ONE, 2013 BACKGROUND: Endocrine treatment is the most preferable systemic treatment in metastatic breast cancer patients that have had an estrogen receptor (ER) positive primary tumor or metastatic lesions, however, approximately 20% of these patients do not ...
Anna Babayan +5 more
doaj +1 more source
Serum keratin 19 (
Liver International, 2022 AbstractBackground and AimsUp to 30% of patients with severe alcoholic hepatitis (sAH) die within 3 months of presentation. The degree of ductular reaction, characterized by accumulation of biliary and liver progenitor cells, confers a poor prognosis.
Stephen Rahul Atkinson +8 more
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Cell Transplantation, 2021 When using human induced pluripotent stem cells (hiPSCs) to achieve hair follicle (HF) replacement, we found it best to emulate the earliest fundamental developmental processes of gastrulation, ectodermal lineage commitment, and dermogenesis.
Michel R. Ibrahim +4 more
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MCF-7 Human Breast Cancer Cells Form Differentiated Microtissues in Scaffold-Free Hydrogels.
PLoS ONE, 2015 Three-dimensional (3D) cultures are increasing in use because of their ability to represent in vivo human physiology when compared to monolayer two-dimensional (2D) cultures.
Marguerite M Vantangoli +4 more
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A Ca2+-Mediated Switch of Epiplakin from a Diffuse to Keratin-Bound State Affects Keratin Dynamics
, 2022 Keratins exert important structural but also cytoprotective functions. They have to be adaptable to support cellular homeostasis. Epiplakin (EPPK1) has been shown to decorate keratin filaments in epithelial cells and to play a protective role under ...
Rudolf E. Leube +9 more
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