Results 51 to 60 of about 5,007,575 (281)

Heterogeneity of estrogen receptor expression in circulating tumor cells from metastatic breast cancer patients. [PDF]

PLoS ONE, 2013
BACKGROUND: Endocrine treatment is the most preferable systemic treatment in metastatic breast cancer patients that have had an estrogen receptor (ER) positive primary tumor or metastatic lesions, however, approximately 20% of these patients do not ...
Anna Babayan, Juliane Hannemann, Julia Spötter, Volkmar Müller, Klaus Pantel, Simon A Joosse   +5 more
doaj   +1 more source

The Developmental & Molecular Requirements for Ensuring that Human Pluripotent Stem Cell-Derived Hair Follicle Bulge Stem Cells Have Acquired Competence for Hair Follicle Generation Following Transplantation

Cell Transplantation, 2021
When using human induced pluripotent stem cells (hiPSCs) to achieve hair follicle (HF) replacement, we found it best to emulate the earliest fundamental developmental processes of gastrulation, ectodermal lineage commitment, and dermogenesis.
Michel R. Ibrahim, Walid Medhat, Hasan El-Fakahany, Hamza Abdel-Raouf, Evan Y. Snyder   +4 more
doaj   +1 more source

MCF-7 Human Breast Cancer Cells Form Differentiated Microtissues in Scaffold-Free Hydrogels.

PLoS ONE, 2015
Three-dimensional (3D) cultures are increasing in use because of their ability to represent in vivo human physiology when compared to monolayer two-dimensional (2D) cultures.
Marguerite M Vantangoli, Samantha J Madnick, Susan M Huse, Paula Weston, Kim Boekelheide   +4 more
doaj   +1 more source

Lung Cancer-Associated Keratin 19 Fragments: Development and Biochemical Characterisation of the New Serum Assay Enzymun-Test Cyfra 21–1

The International Journal of Biological Markers, 1994
From a panel of 4 murine monoclonal antibodies directed against keratin 19 various antibody combinations were evaluated in solid-phase enzyme-linked sandwich immunoassays for detection of soluble keratin 19 fragments in patient sera.
H. Bodenmüller, B. Ofenloch-Hähnle, E.B. Lane, A. Dessauer, V. Böttger, F. Donié   +5 more
doaj   +1 more source

Detection of lymph node metastasis in lung cancer patients using a one-step nucleic acid amplification assay: a single-centre prospective study

Journal of Translational Medicine, 2019
Background The use of one-step nucleic acid amplification (OSNA) allows for lymph node (LN) metastasis to be detected rapidly and accurately. We conducted a prospective single-centre clinical trial to evaluate OSNA assay in detecting LN metastasis of ...
María Escalante Pérez, María Teresa Hermida Romero, Begoña Otero Alén, Mónica Álvarez Martínez, Ricardo Fernández Prado, Mercedes de la Torre Bravos, Ángel Concha López   +6 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Upcycling Keratin‐Based Textile Waste Into High‐Performance Hybrid Fibers Via Tuning the Interfacial Interactions

Advanced Functional Materials, EarlyView.
Keratin recovered from animal‐hair textile waste is fractionated and blended with cellulose to produce continuously spun hybrid fibers. Selecting the high‐molecular‐weight keratin fraction enables 30 wt.% keratin incorporation while maintaining high strength in dry and wet states.
Mian Zhai, Daniel Van Opdenbosch, Inge Schlapp‐Hackl, Teemu Välisalmi, Markus Linder, Michael Hummel, Wenwen Fang   +6 more
wiley   +1 more source

The role of Grafting in Canal Wall down Mastoidectomy Comparative Study [PDF]

Zagazig University Medical Journal
Background: Radical mastoidectomy is the outstanding standard technique for management of cholesteatoma. Long term studies showed increasing incidence of discharging cavities .
essam mohammed, alaaedein farouk, Wael Alzamel   +2 more
doaj   +1 more source

Cross-talk between microRNA-let7c and transforming growth factor-β2 during epithelial-to-mesenchymal transition of retinal pigment epithelial cells [PDF]

International Journal of Ophthalmology, 2020
AIM: To explore the roles of microRNA-let7c (miR-let7c) and transforming growth factor-β2 (TGF-β2) and cellular signaling during epithelial-to-mesenchymal transition (EMT) of retinal pigment epithelial cells. METHODS: Retinal pigment epithelial (ARPE-19)
Qu-Zhen Deji, Feng Yan, Wang-Dui Zhaba, Ya-Jun Liu, Jie Yin, Zhen-Ping Huang   +5 more
doaj   +1 more source

Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin [PDF]

Experimental Dermatology, 2014
AbstractSIRT2 is a member of the mammalian sirtuin family (SIRT1‐7). As compared with other sirtuins, SIRT2 is found primarily in the cytoplasm. It regulates multiple physiological processes. However, the precise role of SIRT2 in skin cancer remains unclear.
Mei, Ming, Lei, Qiang, Baozhong, Zhao, Yu-Ying, He   +3 more
openaire   +2 more sources