Results 111 to 120 of about 8,643,049 (268)
Angewandte Chemie, EarlyView.Myxoglucamid A – ein neuartiges, aus Myxobakterien isoliertes Glykolipopeptid – wurde erstmals totalsynthetisch hergestellt. Mittels aktivitätsbasierter Proteinprofilierung (ABPP) wurde die Aldo‐Keto‐Reduktase 1C3 (AKR1C3) als primäres Zielprotein in menschlichen Zellen identifiziert.
Thomas Siemon +9 more
wiley +1 more source
Actomyosin forces trigger a conformational change in desmoplakin within desmosomes
Nature CommunicationsDesmosomes are essential cell-cell adhesion organelles that enable tension-prone tissues, like the skin and heart, to withstand mechanical stress.
Yinchen Dong +6 more
doaj +1 more source
Cellular expansion of hepatocellular carcinoma organoids using decellularized liver scaffolds
Clinical Transplantation and ResearchBackground : A decellularized liver scaffold (DLS) is a three-dimensional acellular extracellular matrix created by removing cellular components from liver tissue. Hepatocellular carcinoma (HCC) organoids represent a useful experimental model.
Shin Hwang +4 more
doaj +1 more source
Expression pattern of keratin 14.
, 2015 Paraffin-embedded sections of human term placenta are stained with keratin 14 (CK14) along with Vimentin, keratin 19 (CK19), keratin 8 (CK8) and keratin 7 (CK7). Dapi is used to counterstain the nucleus. Representative images of 3 different placentas are
Wassim Abou-Kheir (201647) +4 more
core +1 more source
Angewandte Chemie International Edition, EarlyView.Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon +9 more
wiley +1 more source
Bite force estimates and morphological correlations of jaw muscles in parrots
The Anatomical Record, EarlyView.Abstract Parrots (Order: Psittaciformes) are renowned for their high bite force (BF) and morphological correlates thereof, including a highly mobile skull and two unique mandibular adductor muscles—m. pseudomasseter and m. ethmomandibularis, with the former being hypothesized to increase force output.
Ana Carolina L. Faillace +3 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2015 Based on molecular features, breast cancers are grouped into intrinsic subtypes that have different prognoses and therapeutic response profiles. With increasing age, breast cancer incidence increases, with hormone receptor-positive and other luminal-like
Jonathan K Lee +4 more
doaj +1 more source
Keratin coated titanium as an aid to osseointegration: Physicochemical and mechanical properties
, 2023 Wool-extracted keratin has been shown to promote bone formation in vivo and may therefore be a potential novel bioactive coating material for osseous implants.
Love, Robert M +5 more
core +1 more source
Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis
Animal Research and One Health, EarlyView.Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).
Hao Li +10 more
wiley +1 more source
HERC4 downregulates KRT19 to promote lung adenocarcinoma, migration, invasion and EMT
Translational OncologyBackground: Metastasis is a major cause of treatment failure and poor prognosis in lung adenocarcinoma (LUAD). Epithelial-mesenchymal transition (EMT) plays a crucial role in promoting LUAD metastasis.
Hao-Jia Sun +4 more
doaj +1 more source