Results 131 to 140 of about 55,822 (247)

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source

Hair Degradation Patterns in Aquatic and Soil Environments

Archaeometry, EarlyView.
ABSTRACT Hair is a biological material that can provide information in archaeology and forensics. Previous studies have mainly examined changes occurring post‐mortem. In this study, we focused on hair pulled out ante‐mortem. The aim of the study was to identify patterns in the degradation of hair in water and soil.
Katarzyna Palacz‐Ziółek, Monika Krzyżanowska, Rafał Ogórek, Marcin Kadej   +3 more
wiley   +1 more source

A luminal non‐coding RNA‐based genomic classifier confirms favourable outcomes in patients with clinically organ‐confined bladder cancer treated with radical cystectomy

BJU International, Volume 135, Issue 4, Page 648-656, April 2025.
Objective To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.
Joep J. de Jong, James A. Proudfoot, Siamak Daneshmand, Robert S. Svatek, Vikram Narayan, Ewan A. Gibb, Elai Davicioni, Shreyas Joshi, Aaron Dahmen, Roger Li, Brant A. Inman, Paras Shah, Iftach Chaplin, Jonathan Wright, Yair Lotan   +14 more
wiley   +1 more source

Impact of Copper Nanoparticles on Keratin 19 (KRT19) Gene Expression in Breast Cancer Subtypes: Integrating Experimental and Bioinformatics Approaches. [PDF]

Int J Mol Sci
Taha S, Sultan A, Aljishi M, Greish K.
europepmc   +1 more source

Cellular characteristics of keratin 19-positive canine hepatocellular tumours explain its aggressive behaviour. [PDF]

Vet Rec Open, 2017
van Sprundel RG, van den Ingh TS, Schotanus BA, van Wolferen ME, Penning LC, Rothuizen J, Spee B.   +6 more
europepmc   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Downregulation of KRTAP2‐3 Suppresses Proliferation and Tumor Formation of Oral Cancer Cells via Inactivation of KRAS Signals

Cancer Science, EarlyView.
KRTAP2‐3 drives OSCC progression by sustaining both mesenchymal and proliferative properties through KRAS signaling. Loss of KRTAP2‐3 induces MET, suppresses KRAS pathway activation, and markedly reduces tumor cell proiferation and tumor formation as illustarted in Figure.
Qianqian Miao, Zhijun Huang, Kazuki Takahashi, Haruka Ibi, Kohei Miyazono, Katarzyna A. Podyma‐Inoue, Tetsuro Watabe   +6 more
wiley   +1 more source

Identification of keratin 19-positive cancer stem cells associating human hepatocellular carcinoma using CYFRA 21-1. [PDF]

Cancer Med, 2017
Kawai T, Yasuchika K, Ishii T, Katayama H, Yoshitoshi EY, Ogiso S, Minami T, Miyauchi Y, Kojima H, Yamaoka R, Kita S, Yasuda K, Sasaki N, Fukumitsu K, Hatano E, Uemoto S.   +15 more
europepmc   +1 more source

940 LOSS OF KERATIN 19 PREDISPOSES TO THE DEVELOPMENT OF CHOLESTATIC LIVER DISEASE [PDF]

Journal of Hepatology, 2012
Y. Chen, N. Güldiken, M.B. Omary, J. Hayback, P. Strnad   +4 more
openaire   +1 more source

Epithelial YPEL3 Modulates CD8+ T‐Cell Infiltration and Tumor Progression Through CREB1–CXCL16 Signaling in HNSCC

Cancer Science, EarlyView.
YPEL3 functions as a tumor suppressor in HNSCC by inhibiting tumor progression and promoting apoptosis. Mechanistically, it enhances epithelial–immune crosstalk through the CREB1‐mediated CXCL16–CXCR6 axis, facilitating CD8+ T‐cell infiltration and highlighting its potential as a prognostic biomarker and immunotherapy target.
Yalun Li, Yumei Li, Caiyu Sun, Congxian Lu, Gang Chen, Tianshu Zhou, Bei Zhang, Xicheng Song   +7 more
wiley   +1 more source