Results 41 to 50 of about 8,643,049 (268)

Keratin 19 regulates cell cycle pathway and sensitivity of breast cancer cells to CDK inhibitors

Scientific Reports, 2019
Keratin 19 (K19) belongs to the keratin family of proteins, which maintains structural integrity of epithelia. In cancer, K19 is highly expressed in several types where it serves as a diagnostic marker.
Pooja Sharma, Sarah Alsharif, Karina Bursch, Swetha Parvathaneni, D. Anastasakis, Joeffrey J. Chahine, A. Fallatah, Kevin Nicolas, Sudha Sharma, Markus Hafner, B. Kallakury, B. Chung   +11 more
semanticscholar   +1 more source

Keratin 19 interacts with GSK3β to regulate its nuclear accumulation and degradation of cyclin D3 [PDF]

Molecular Biology of the Cell, 2021
Abstract Cyclin D3 regulates the G1/S transition and is frequently overexpressed in several cancer types including breast cancer, where it promotes tumor progression. Here, we show that a cytoskeletal protein keratin 19 (K19) physically interacts with a serine/threonine kinase GSK3β and prevents GSK3β-dependent degradation of cyclin D3.
Pooja Sharma, Sarah Tiufekchiev, Victoria Lising, Seung Woo Chung, Jung Soo Suk, Byung Min Chung   +5 more
openaire   +3 more sources

Keratin 19 Expression in Hepatocellular Carcinoma Is Regulated by Fibroblast-Derived HGF via a MET-ERK1/2-AP1 and SP1 Axis.

Cancer Research, 2018
Keratin (KRT) 19 is a poor prognostic marker for hepatocellular carcinoma (HCC); however, regulatory mechanisms underlying its expression remain unclear.
H. Rhee, Hye-Young Kim, Ji-Hye Choi, H. Woo, Jeong-Eun Yoo, J. Nahm, J. Choi, Y. N. Park   +7 more
semanticscholar   +1 more source

Keratin-Butyrate Scaffolds Promote Skin Wound Healing in Diabetic Rats Through Down-Regulation of IL-1β and Up-Regulation of Keratins 16 and 17

, 2022
Impaired wound healing particularly in diabetics creates a significant healthcare burden. The study aimed to evaluate the effect of keratin-butyrate fibers (FKDP +0.1%NaBu) in a full-thickness skin wound model in 30 diabetic rats.
Mateusz Rybka (14011570), Emilia Samborowska (4683826), Bartłomiej Cieślik (5068253), Marek Konop (4405183), Piotr Konopelski (14011588), Łukasz Mazurek (14011573), Anna K. Laskowska (13885530), Adam Waszkowski (14011585), Robert A. Schwartz (3213558), Rafał Mazgaj (14011579), Zbigniew Ruszczak (14011576), Dorota Sulejczak (615690), Mateusz Szudzik (13965413), Jakub Frankowski (14011582), Joanna Czuwara (4405171)   +14 more
core   +1 more source

Histomorphological observation of surgical debridement combined with negative pressure therapy in treatment of diabetic foot

Chinese Journal of Traumatology, 2017
Purpose: To further study the mechanism of epithelization on the fascia side of the flap after surgical incision and the treatment of the negative pressure therapy.
Jiao-Yun Dong, Fei Song, Chun Qing, Shu-Liang Lu   +3 more
doaj   +1 more source

Similarities in DSG1 and KRT3 Downregulation through Retinoic Acid Treatment and PAX6 Knockdown Related Expression Profiles: Does PAX6 Affect RA Signaling in Limbal Epithelial Cells?

Biomolecules, 2021
Congenital PAX6-aniridia is a rare panocular disease resulting from limbal stem cell deficiency. In PAX6-aniridia, the downregulation of the retinol-metabolizing enzymes ADH7 (All-trans-retinol dehydrogenase 7) and ALDH1A1/A3 (Retinal dehydrogenase 1 ...
Lorenz Latta, Igor Knebel, Constanze Bleil, Tanja Stachon, Priya Katiyar, Claire Zussy, Fabian Norbert Fries, Barbara Käsmann-Kellner, Berthold Seitz, Nóra Szentmáry   +9 more
doaj   +1 more source

Clinical and Prognostic Significances of Cytokeratin 19 and KIT Expression in Surgically Resectable Pancreatic Neuroendocrine Tumors [PDF]

Journal of Pathology and Translational Medicine, 2015
Background: Pancreatic neuroendocrine tumors (PanNETs) are malignant endocrine neoplasms that present diverse clinical behaviors. Therefore, identification of biomarkers of PanNETs is important for stratification of the prognosis of PanNET patients ...
Eun-Mi Son, Joo Young Kim, Soyeon An, Ki-Byung Song, Song Cheol Kim, Eunsil Yu, Seung-Mo Hong   +6 more
doaj   +1 more source

Pancreatic cancer cells assemble a CXCL12-keratin 19 coating to resist immunotherapy

bioRxiv, 2019
How pancreatic ductal adenocarcinoma (PDA) cells stimulate CXCR4 to exclude T cells and resist T cell checkpoint inhibitors is not known. Here, we find that CXCL12, the ligand for CXCR4 that is produced by the cancer-associated fibroblast, “coats” human ...
Zhikai Wang, Ran Yan, Jiayun Li, Ya Gao, Philip Moresco, Min Yao, J. Hechtman, Matthew J. Weiss, T. Janowitz, D. Fearon   +9 more
semanticscholar   +1 more source

Immunohistochemical Demonstration of Keratin 19 Expression in Isolated Human Hair Follicles

Journal of Investigative Dermatology, 1994
We examined keratins 19 and 8 in extracted human hair follicles using monoclonal antibodies Ks19.1 and CAM5.2, respectively. Ks19.1 reactivity was found in the bulge and infundibulum. Ks19.1(+) cells were dense in the bulge of vellus and intermediate hair follicles. The intact bulge of terminal hair could not be extracted, but the presence of Ks19.1(+)
Narisawa, Yutaka, Kohda, Hiromu, Hashimoto, K.e.n.   +2 more
openaire   +2 more sources

Keratin intermediate filaments in the colon: guardians of epithelial homeostasis [PDF]

, 2020
Keratin intermediate filament proteins are major cytoskeletal components of the mammalian simple layered columnar epithelium in the gastrointestinal tract.
Heikkil�, Taina, Tayyab, Mina, Baghestani, Sarah, Toivola, Diana M., Nystr�m, Joel H., Alam, Catharina M., Polari, Lauri   +6 more
core   +1 more source