Results 211 to 220 of about 55,822 (247)

Keratin 19 as a Stem Cell Marker In Vivo and In Vitro

2004
The skin is a dynamic tissue in which terminally differentiated keratinocytes are replaced by the proliferation of new epithelial cells that will undergo differentiation. The rapid and continual turnover of skin throughout life depends on a cell population with unique characteristics: the stem cells.
Fortier, Kristine, Germain, Lucie, Larouche, Danielle, Hayward, Cindy Jean   +3 more
openaire   +3 more sources

Keratin 19 in the adult human prostate: tissue and cell culture studies

Cell and Tissue Research, 1996
Keratin 19 is found primarily in simple epithelia. In mammary epithelia, keratin 19 was localized to a subset of luminal cells, suggesting that keratin 19-negative cells may be the proliferative compartment of the secretory cell lineage. The structural and functional similarities of prostate and breast led us to examine keratin 19 expression in the ...
D M, Peehl, R G, Sellers, J E, McNeal
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The mouse keratin 19-encoding gene: sequence, structure and chromosomal assignment

Gene, 1990
Keratin 19 (K19) is synthesized mainly in embryonic and adult simple epithelia, but has also been found in stratified epithelia as well. K19 is the smallest known keratin and is remarkable in that, contrary to all other keratins, it does not have a designated partner for the formation of filaments, implying that regulation of its expression is ...
Lussier, M, Filion, M, Compton, J G, Nadeau, J H, Lapointe, L, Royal, A   +5 more
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Genomic Organization and Amplification of the Human Keratin 15 and Keratin 19 Genes

Biochemical and Biophysical Research Communications, 2000
Keratin intermediate filaments are the major components of the cytoskeleton in epithelial cells. Mutations in keratin genes have been documented in many disorders of the skin, nails, hair, and mucous membranes. Although no mutations have been described in either keratin 15 or keratin 19, they are good candidates for other as yet uncharacterized genetic
Whittock, N V, Eady, R A J, McGrath, J A
openaire   +3 more sources

Keratin 19-like immunoreactivity in receptor cells of mammalian taste buds

Chemical Senses, 1994
Three monoclonal antibodies, 4.62, LP2K and 170.2.14, were used to evaluate keratin 19-like immunoreactivity in gustatory epithelia. Keratin 19-like immunoreactivity was restricted to the intragemmal cells for all types of mammalian taste buds examined.
L, Wong, B, Oakley, A, Lawton, Y, Shiba
openaire   +2 more sources

Identification of Epithelial Stem Cells In Vivo and In Vitro Using Keratin 19 and BrdU

2009
Progress in the identification of skin stem cells and the improvement of culture methods open the possibility to use stem cells in regenerative medicine. Based on their quiescent nature, the development of label retention assays allowed the localization of skin stem cells in the bulge region of the pilosebaceous units and in the bottom of rete ridges ...
Germain, Lucie, Larouche, Danielle, Paquet, Claudie, Simard-Bisson, Carolyne, Lavoie, Amélie   +4 more
openaire   +3 more sources

The keratin 19 promoter is potent for cell-specific targeting of genes in transgenic mice

Gastroenterology, 2001
Keratins are intermediate filaments that are critical in cytoskeletal organization. Their roles in cellular processes are underscored by inherited human diseases in which germline mutations of keratins are found, as well as by transgenic and knockout mouse models that recapitulate those diseases.
F H, Brembeck, J, Moffett, T C, Wang, A K, Rustgi   +3 more
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Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization

Journal of Cell Science, 2007
Intermediate filaments, composed of desmin and of keratins, play important roles in linking contractile elements to each other and to the sarcolemma in striated muscle. We examined the contractile properties and morphology of fast-twitch skeletal muscle from mice lacking keratin 19.
Michele R, Stone, Andrea, O'Neill, Richard M, Lovering, John, Strong, Wendy G, Resneck, Patrick W, Reed, Diana M, Toivola, Jeanine A, Ursitti, M Bishr, Omary, Robert J, Bloch   +9 more
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Expression of monoclonal antibody-defined epitopes of keratin 19 in human tumours and cultured cells

European Journal of Cancer and Clinical Oncology, 1986
The monoclonal antibodies BA16 and BA17, reacting specifically with human keratin 19 (40 kD) have been tested by immunohistochemical staining methods for their reaction with a wide range of human tumours and cultured cells. Primary adenocarcinomas and their metastases showed a homogeneously positive reaction with greater than 95% of the tumour cells ...
J, Bártek, J, Bártková, J, Schneider, J, Taylor-Papadimitriou, J, Kovarík, A, Rejthar   +5 more
openaire   +2 more sources

Mouse keratin 19: complete amino acid sequence and gene expression during development

Gene, 1989
The complete amino acid sequence of the mouse keratin 19 (K19) was determined from a partial sequence of cDNA isolated from a mouse (day 10.5) embryo library and an amplified genomic fragment. Analysis of the sequence reveals strong evolutionary conservation with other K19s.
M, Lussier, T, Ouellet, C, Lampron, L, Lapointe, A, Royal   +4 more
openaire   +2 more sources