Results 91 to 100 of about 62,676,716 (288)

The pancreatic and duodenal homeobox protein PDX-1 regulates the ductal specific keratin 19 through the degradation of MEIS1 and DNA binding. [PDF]

PLoS ONE, 2010
Pancreas organogenesis is the result of well-orchestrated and balanced activities of transcription factors. The homeobox transcription factor PDX-1 plays a crucial role in the development and function of the pancreas, both in the maintenance of ...
Johannes von Burstin, Maximilian Reichert, Melanie P Wescott, Anil K Rustgi   +3 more
doaj   +1 more source

The interaction between the HPV E1^E4 protein and the cell cytoskeleton. [PDF]

, 2007
Papillomaviruses are small DNA viruses, which cause benign and malignant lesions in the differentiated epithelium of mammals and birds. A small subset of human papillomaviruses (HPV's), have been identified as the etiological agent of cervical cancer ...
Laskey, P.
core  

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

A Keratin-Waste Derived Multifunctional Gel System: Reusable Activated Carbon/Alginate Microbeads for Simultaneous Dye and Pharmaceutical Adsorption

Gels
The resource utilization of keratin waste has garnered significant attention, yet the processing of yak hair keratin in underdeveloped regions such as Tibet and Qinghai in China remains challenging.
Yue Wang, Lei Zhao, Zhiying Li, Qingqing Xue, Zhenhao Tang, Ge Zhang, Zhiqiang Li, Zifan Wang   +7 more
doaj   +1 more source

Keratin 19 mRNA measurement to detect micrometastases in lymph nodes in breast cancer patients [PDF]

British Journal of Cancer, 1996
We have used polymerase chain reaction (PCR) to measure keratin 19 mRNA in order to detect breast cancer cells invading axillary lymph nodes. In a consecutive series of 125 patients with primary breast cancer, 75 patients had no evidence of lymph node involvement by conventional histology.
A, Schoenfeld, Y, Luqmani, H D, Sinnett, S, Shousha, R C, Coombes   +4 more
openaire   +2 more sources

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

CaMKIIδ Phosphorylates AUP1 to Promote Pancreatic Tissue Repair and Acinar‐to‐Ductal Metaplasia Formation via Mediating PERK‐Dependent Unfolded Protein Responses

Advanced Science, EarlyView.
CaMKIIδ–AUP1 signaling maintains PERK‐dependent ER homeostasis during ADM‐mediated pancreatic repair. ABSTRACT Pancreatic repair after acute pancreatitis (AP) is essential for restoring tissue integrity, but the intrinsic mechanisms coordinating acinar plasticity and regeneration remain poorly understood.
Yonghao Chen, Ziying Han, Zihan Yang, Jie Wu, Kaixin Peng, Xiuli Zhang, Bintao Qiu, Jianqiang Wu, Xiaomin Hu, Dong Wu, Li Wen   +10 more
wiley   +1 more source

Nasal Tuft Cell Markers Are Predictive of Overall Survival in Sinonasal Neuroendocrine and Sinonasal Undifferentiated Carcinomas

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Sinonasal neuroendocrine carcinoma (SNEC) and sinonasal undifferentiated carcinoma (SNUC) are rare aggressive malignancies with no established prognostic markers. Because features of POU2F3+ small cell lung carcinomas have been identified in both tumors, we evaluated immunostaining for POU2F3, a tuft cell transcription factor, and ...
Nikolina Dioufa, Ricardo V. Bruneto, Jennifer E. Douglas, Nithin D. Adappa, James N. Palmer, Noam A. Cohen, Michael A. Kohanski   +6 more
wiley   +1 more source

Voiding symptoms aggravate with decreasing stromal/epithelial ratio and increasing glandular-epithelial content in patients undergoing laser enucleation for benign prostatic hyperplasia, independently from prostate size.

PLoS ONE
IntroductionBenign prostatic hyperplasia (BPH) includes epithelial, stromal and mixed hyperplasia, but their specific contributions to voiding symptoms and prostate volume (PV) are unknown.
Patrick Keller, Sheng Hu, Wenbin Zhu, Yajie Xu, Laurenz Berger, Philip Nicola, Philipp Weinhold, Alexander Tamalunas, Christian G Stief, Martin Hennenberg   +9 more
doaj   +1 more source

Cellular expansion of hepatocellular carcinoma organoids using decellularized liver scaffolds

Clinical Transplantation and Research
Background : A decellularized liver scaffold (DLS) is a three-dimensional acellular extracellular matrix created by removing cellular components from liver tissue. Hepatocellular carcinoma (HCC) organoids represent a useful experimental model.
Shin Hwang, I-Ji Jung, Kyoung-Jin Lee, Yun-Kyu Kim, Eunyoung Tak   +4 more
doaj   +1 more source