Results 11 to 20 of about 62,676,716 (288)

Morphology, Motility, and Cytoskeletal Architecture of Breast Cancer Cells Depend on Keratin 19 and Substrate [PDF]

Cytometry Part A, 2020
AbstractCancer cells gain motility through events that accompany modulation of cell shape and include altered expression of keratins. However, the role of keratins in change of cancer cell architecture is not well understood. Therefore, we ablated the expression of keratin 19 (K19) in breast cancer cells of the MDA‐MB‐231 cell line and found that cells
Van K. Lam, Pooja Sharma, Thanh Nguyen, Georges Nehmetallah, Christopher B. Raub, Byung Min Chung   +5 more
openaire   +3 more sources

Serum keratin 19 (CYFRA21-1) links ductular reaction with portal hypertension and outcome of various advanced liver diseases [PDF]

BMC Medicine, 2020
Background Keratins (Ks) represent tissue-specific proteins. K18 is produced in hepatocytes while K19, the most widely used ductular reaction (DR) marker, is found in cholangiocytes and hepatic progenitor cells.
Karim Hamesch, Nurdan Guldiken, Mahmoud Aly, Norbert Hüser, Daniel Hartmann, Pierre Rufat, Marianne Ziol, Katharina Remih, Georg Lurje, Bernhard Scheiner, Christian Trautwein, Mattias Mandorfer, Thomas Reiberger, Sebastian Mueller, Tony Bruns, Pierre Nahon, Pavel Strnad   +16 more
doaj   +2 more sources

Genomic organization and amplification of the human keratin 15 and keratin 19 genes

Biochemical and Biophysical Research Communications, 2000
Keratin intermediate filaments are the major components of the cytoskeleton in epithelial cells. Mutations in keratin genes have been documented in many disorders of the skin, nails, hair, and mucous membranes.
McGrath, J A, Whittock, N V, Eady, R A J
core   +4 more sources

Keratin 19 as a key molecule in progression of human hepatocellular carcinomas through invasion and angiogenesis [PDF]

BMC Cancer, 2016
Keratin (K) 19-positive hepatocellular carcinoma (HCC) is well known to have a higher malignant potential than K19-negative HCC: However, the molecular mechanisms involved in K19-mediated progression of HCC remain unclear. We attempted to clarify whether K19 directly affects cell survival and invasiveness in association with cellular senescence or ...
Takano, Masato, Shimada, Keiji, Fujii, Tomomi, Morita, Kohei, Takeda, Maiko, Nakajima, Yoshiyuki, Nonomura, Akitaka, Konishi, Noboru, Obayashi, Chiho   +8 more
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer [PDF]

Molecular Oncology
High‐grade serous ovarian cancer (HGSOC) is the most prevalent and lethal subtype of epithelial ovarian cancer (EOC), characterised by extensive peritoneal metastasis. The intermediate filament keratin 19 (KRT19) has been linked to tumour progression and
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
doaj   +2 more sources

Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization

Journal of Cell Science, 2007
Intermediate filaments, composed of desmin and of keratins, play important roles in linking contractile elements to each other and to the sarcolemma in striated muscle.
Resneck, Wendy G., Reed, Patrick W., Richard M. Lovering, Omary, M. Bishr, Ursitti, Jeanine A., Toivola, Diana M., Andrea O'Neill, Bloch, Robert J., O’Neill, Andrea, Wendy G. Resneck, Patrick W. Reed, Jeanine A. Ursitti, Strong, John, John Strong, Robert J. Bloch, M. Bishr Omary, Stone, Michele R., Lovering, Richard M., Diana M. Toivola, Michele R. Stone   +19 more
core   +3 more sources

The correlation of keratin expression with in-vitro epithelial cell line differentiation [PDF]

, 2009
MPhil 2009 QMThe mechanism of transcriptional regulation which allows oral mucosal-specific expression of the human keratin 13 (K13) gene remains unknown.
Aden, Deeqo
core   +4 more sources

Improving the Adsorption Properties of Keratin-Based Goat Hair Toward Reactive Dyes in Dyeing Wastewater by Steam Explosion

Journal of Natural Fibers, 2023
Keratin-based goat hair could be used bioadsorbent due to its large availability, biodegradability and low cost. Unfortunately, most available keratin adsorbents are either low in adsorption capacity or high in preparation cost.
Shijin Wei, Xiuliang Hou, Linyun Liu, Yue Tian, Wei Li, Helan Xu   +5 more
doaj   +1 more source

Keratin 19: a key role player in the invasion of human hepatocellular carcinomas [PDF]

Gut, 2013
Objective Keratin (K)19, a biliary/hepatic progenitor cell (HPC) marker, is expressed in a subset of hepatocellular carcinomas (HCC) with poor prognosis. The underlying mechanisms driving this phenotype of K19-positive HCC remain elusive. Design
Govaere, Olivier, Komuta, M.Ina, Berkers, Joost, Spee, Bart, Janssen, Carl, de Luca, Francesca, Katoonizadeh, Aezam, Wouters, Jasper, van Kempen, Léon C., Durnez, Anne, Verslype, Chris, De Kock, Joery, Rogiers, Vera, van Grunsven, Leo A., Topal, Baki, Pirenne, Jacques, Vankelecom, Hugo, Nevens, Frederik, van den Oord, Joost, Pinzani, Massimo, Roskams, Tania   +20 more
openaire   +7 more sources

Efficient isolation of keratin from protein-rich waste biomass: a practical approach to minimize environmental impact and valorize waste biomass

Sustainable Environment Research, 2022
Among various protein-containing biomass wastes, waste animal wool, poultry feather, and human hair are considered one of the most important renewable sources of keratin.
Tapan Kumar Maity, Nripat Singh, Pradipkumar Vaghela, Arup Ghosh, Sanju Singh, Pramod B. Shinde, Rosy Alphons Sequeira, Kamalesh Prasad   +7 more
doaj   +1 more source