Results 81 to 90 of about 55,822 (247)

Actomyosin forces trigger a conformational change in desmoplakin within desmosomes

Nature Communications
Desmosomes are essential cell-cell adhesion organelles that enable tension-prone tissues, like the skin and heart, to withstand mechanical stress.
Yinchen Dong, Ahmed Elgerbi, Bin Xie, Yerin Han, Adam V. Kwiatkowski, John S. Choy, Sanjeevi Sivasankar   +6 more
doaj   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source

HERC4 downregulates KRT19 to promote lung adenocarcinoma, migration, invasion and EMT

Translational Oncology
Background: Metastasis is a major cause of treatment failure and poor prognosis in lung adenocarcinoma (LUAD). Epithelial-mesenchymal transition (EMT) plays a crucial role in promoting LUAD metastasis.
Hao-Jia Sun, Ming-Hui Peng, Zi-Yang Feng, Hua Fu, Xue-Wen Liu   +4 more
doaj   +1 more source

The Diagnostic Value of Immunohistochemistry and Biomarkers in the Diagnosis of Mesothelioma in Pleural/Peritoneal Effusions

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background Mesothelioma is a rare tumor that arises from the serosal cells lining the serous cavities, most commonly the pleura followed by the peritoneum. Presenting symptoms include pleuritic pain and bloody effusions that recur. Although cytologic analysis cannot determine the mesothelial subtype or in situ from invasive disease, the ...
Suzanne M. Selvaggi
wiley   +1 more source

Periocular keratoacanthoma: A clinicopathologic study and diagnostic challenges

The Pan-American Journal of Ophthalmology
Purpose: Keratoacanthoma (KA) is a cutaneous neoplasm that presents as a rapidly growing tumor on ultraviolet light-exposed skin. It appears as an exophytic, crater-like lesion filled with keratin. In periocular sites, the eyelids are most often affected.
Eduardo Ballalai Bordon, Emily Marcotte, Jacqueline Coblentz, Guilherme Feltrin Barros, Christian El-Hadad, Massimo Mazza, Morgan Yurchuk, Miguel Noel Burnier   +7 more
doaj   +1 more source

Sequence of cDNA coding for human keratin 19 [PDF]

Nucleic Acids Research, 1987
P C, Stasiak, E B, Lane
openaire   +2 more sources

Exploring Cerumen as an Alternative Matrix for Drug Detection and Quantification: Method Development and Application in Clinical Samples

Drug Testing and Analysis, EarlyView.
An LC–MS/MS method was developed for the detection of 33 psychoactive medications in cerumen (earwax) and applied to the samples of 60 psychiatric inpatient volunteers. The findings highlighted the utility of cerumen as an innovative biospecimen in clinical toxicological analysis.
Dimitrios Phaedon Kevrekidis, Helen G. Gika, Georgios Panagiotoglou, Eleni Parlapani, Pavlos Pavlidis, Nikolaos Raikos   +5 more
wiley   +1 more source

Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects

iMeta, EarlyView.
Microbiome age (MA) has emerged as an innovative biomarker of biological aging, reflecting host aging trajectories through dynamic alterations in microbial composition, function, and host–microbe interactions across multiple body ecosystems. Diverse computational strategies—including traditional machine learning, deep learning, and multi‐omics ...
Zhexin Ni, Jiaojiao Xie, Zhichun Zhang, Keming Zhang, Jie Ding, Mingyang Chang, Ying Su, Yunan Zhang, Mingfei Yao, Chengyuan Wang, Yan Yan, Wenjie Fang, Hainv Gao, Xuecong Tian, Yangshuo Li, Xinlin Zhu, Wen Zhang, Wanqing Liao, Gaoyuan Xu, Guojing Chen, Xiaoyi Lv, Chaoqin Yu, Weihua Pan, Vadim Molodtsov, Lanjuan Li, Yue Gao, Wei Zhou   +26 more
wiley   +1 more source

Comparison Of Expression Levels Of Keratin 19 (Krt19) and Transmembrane Serine Protease 4 (Tmprss4) Genes in SU.86.86 and BxPC-3 Pancreatic Cancer Cell Lines

Genetics & Applications
In this study, the expression levels of Keratin 19 (KRT 19) and Transmembrane serine protease 4 (TMPRSS4) genes in metastatic pancreatic cancer cell line SU.86.86 and nonmetastatic pancreatic cancer cell line BxPC3 cells were been determined and the ...
Seda Yavuzarslan, Süreyya Bozkurt
doaj   +1 more source