Results 161 to 170 of about 62,676,716 (288)

Low‐level light therapy for dry eye disease and meibomian gland dysfunction: A systematic review and meta‐analysis

Acta Ophthalmologica, EarlyView.
Abstract A healthy tear film is vital for ocular surface integrity and relies on the coordinated function of the lacrimal glands, meibomian glands and conjunctival goblet cells. Dysfunction in any of these elements can lead to dry eye disease (DED). This systematic review and meta‐analysis evaluated the efficacy of low‐level light therapy (LLLT) as a ...
Sjur Reppe, Yousif Subhi, Tore Steinkjer, Mazyar Yazdani, Miriam Kolko, Tor P. Utheim, Fredrik Andreas Fineide   +6 more
wiley   +1 more source

Applications of Keratin Hydrolysates

, 2013
Tato práce se zabývá poznatky o keratinu, keratinových hydrolyzátech a možnostech jejich využití. Dále představuje praktickou přípravu keratinového hydrolyzátu a ověřuje možnost přípravy materiálů z tohoto hydrolyzátu.This work deals with the knowledge ...
Sova, Jaromír
core   +1 more source

Hair Degradation Patterns in Aquatic and Soil Environments

Archaeometry, EarlyView.
ABSTRACT Hair is a biological material that can provide information in archaeology and forensics. Previous studies have mainly examined changes occurring post‐mortem. In this study, we focused on hair pulled out ante‐mortem. The aim of the study was to identify patterns in the degradation of hair in water and soil.
Katarzyna Palacz‐Ziółek, Monika Krzyżanowska, Rafał Ogórek, Marcin Kadej   +3 more
wiley   +1 more source

Proteomic Sex Estimation From Embedded Tooth Enamel

Archaeometry, EarlyView.
ABSTRACT Teeth hold insights into childhood diet, health and demography—including chromosomal sex. Proteomic analysis can detect peptide biomarkers from amelogenin genes encoded on X and Y chromosomes, allowing sex estimation. Embedding resins, necessary for thin sectioning teeth, can damage analytical systems, preventing proteomic analysis. We present
E. L. Sudron, G. Parker, T. Buonasera, K. Burk, C. Canzonieri, J. W. Eerkens, M. Ehlers, D. Loo‐Oey, C. Matheson, M. Salemi, C. Zimmer, T. M. Smith   +11 more
wiley   +1 more source

A luminal non‐coding RNA‐based genomic classifier confirms favourable outcomes in patients with clinically organ‐confined bladder cancer treated with radical cystectomy

BJU International, Volume 135, Issue 4, Page 648-656, April 2025.
Objective To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.
Joep J. de Jong, James A. Proudfoot, Siamak Daneshmand, Robert S. Svatek, Vikram Narayan, Ewan A. Gibb, Elai Davicioni, Shreyas Joshi, Aaron Dahmen, Roger Li, Brant A. Inman, Paras Shah, Iftach Chaplin, Jonathan Wright, Yair Lotan   +14 more
wiley   +1 more source

Keratin 19 regulates cell cycle pathway and sensitivity of breast cancer cells to CDK inhibitors. [PDF]

Sci Rep, 2019
Sharma P, Alsharif S, Bursch K, Parvathaneni S, Anastasakis DG, Chahine J, Fallatah A, Nicolas K, Sharma S, Hafner M, Kallakury B, Chung BM.   +11 more
europepmc   +1 more source

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

Brain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová, Lucie Pfeiferová, Tadeáš Karel Smetana, Petr Výmola, Nikola Ternerová, Michal Zubaľ, Michal Kolář, Jana Šáchová, Soňa Gyönyörová, Eva Balážiová, Magdalena Houdová Megová, Jakub Červenka, Helena Kupcová Skalníková, Michal Španko, Karel Smetana Jr., Lukáš Lacina, David Netuka, Robert Tomáš, Petr Bušek, Aleksi Šedo   +19 more
wiley   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Mitochondrial Morphology Dynamics Remodel Metabolism and Affect TKI Sensitivity in EGFR‐Mutated Lung Cancer

Cancer Science, EarlyView.
TKI treatment promotes mitochondrial fission and metabolic reprogramming toward oxidative phosphorylation in residual EGFR‐mutant lung cancer cells. Targeting this metabolic vulnerability restores TKI sensitivity and provides a promising strategy to overcome acquired resistance.
Yu Zhao, Yuqiang Liu, Mingxuan Xie, Zhiming Ye, Hong Huang, Maojin Yao, Feng Zhou, Jianzhu Zhao, Jun Tang   +8 more
wiley   +1 more source

Heterogeneity of Epigenetic and Epithelial Mesenchymal Transition Marks in Hepatocellular Carcinoma with Keratin 19 Proficiency. [PDF]

Liver Cancer, 2019
Yokomichi N, Nishida N, Umeda Y, Taniguchi F, Yasui K, Toshima T, Mori Y, Nyuya A, Tanaka T, Yamada T, Yagi T, Fujiwara T, Yamaguchi Y, Goel A, Kudo M, Nagasaka T.   +15 more
europepmc   +1 more source