Results 21 to 30 of about 55,960 (248)

The correlation between poor prognosis and increased yes-associated protein 1 expression in keratin 19 expressing hepatocellular carcinomas and cholangiocarcinomas [PDF]

BMC Cancer, 2017
Background The Hippo pathway plays a vital role in liver regeneration and development by determining cellular lineage and regulating cell proliferation and apoptosis.
KyuHo Lee, Kyoung-Bun Lee, Hae Yoen Jung, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Ja-June Jang   +6 more
doaj   +2 more sources

Keratin 19 is a potential diagnostic and prognostic biomarker in pancreatic adenocarcinoma. [PDF]

Medicine (Baltimore)
This study aimed to evaluate Keratin 19 (KRT19) as a potential prognostic biomarker for the diagnosis and prognosis of pancreatic adenocarcinoma (PAAD). Using data from The Cancer Genome Atlas and the Gene Expression Omnibus, we analyzed KRT19 expression in PAAD tissues and identified differentially expressed genes associated with KRT19. Gene ontology (
He L, Li L, Chen Z, Chen Z.
europepmc   +3 more sources

Signal peptide-independent secretion of keratin-19 by pancreatic cancer cells. [PDF]

Proc Natl Acad Sci U S A
Abstract The exclusion of T cells causes immune escape of pancreatic ductal adenocarcinoma (PDA). T cell exclusion is mediated by the interaction between CXCR4 on T cells and its ligand, CXCL12, which is complexed to keratin-19 (KRT19) on the surface of PDA cells.
Moresco P, Kastan JP, Yang JI, Prabakar R, Kelley ZL, Minicozzi F, Adams DW, Cifani P, Tuveson DA, Fearon DT.   +9 more
europepmc   +5 more sources

Morphology, Motility, and Cytoskeletal Architecture of Breast Cancer Cells Depend on Keratin 19 and Substrate. [PDF]

Cytometry A, 2020
AbstractCancer cells gain motility through events that accompany modulation of cell shape and include altered expression of keratins. However, the role of keratins in change of cancer cell architecture is not well understood. Therefore, we ablated the expression of keratin 19 (K19) in breast cancer cells of the MDA‐MB‐231 cell line and found that cells
Lam VK, Sharma P, Nguyen T, Nehmetallah G, Raub CB, Chung BM.   +5 more
europepmc   +4 more sources

Improving the Adsorption Properties of Keratin-Based Goat Hair Toward Reactive Dyes in Dyeing Wastewater by Steam Explosion

Journal of Natural Fibers, 2023
Keratin-based goat hair could be used bioadsorbent due to its large availability, biodegradability and low cost. Unfortunately, most available keratin adsorbents are either low in adsorption capacity or high in preparation cost.
Shijin Wei, Xiuliang Hou, Linyun Liu, Yue Tian, Wei Li, Helan Xu   +5 more
doaj   +1 more source

Efficient isolation of keratin from protein-rich waste biomass: a practical approach to minimize environmental impact and valorize waste biomass

Sustainable Environment Research, 2022
Among various protein-containing biomass wastes, waste animal wool, poultry feather, and human hair are considered one of the most important renewable sources of keratin.
Tapan Kumar Maity, Nripat Singh, Pradipkumar Vaghela, Arup Ghosh, Sanju Singh, Pramod B. Shinde, Rosy Alphons Sequeira, Kamalesh Prasad   +7 more
doaj   +1 more source

Keratin 19: a key role player in the invasion of human hepatocellular carcinomas [PDF]

Gut, 2013
Objective Keratin (K)19, a biliary/hepatic progenitor cell (HPC) marker, is expressed in a subset of hepatocellular carcinomas (HCC) with poor prognosis. The underlying mechanisms driving this phenotype of K19-positive HCC remain elusive. Design
Govaere, Olivier, Komuta, M.Ina, Berkers, Joost, Spee, Bart, Janssen, Carl, de Luca, Francesca, Katoonizadeh, Aezam, Wouters, Jasper, van Kempen, Léon C., Durnez, Anne, Verslype, Chris, De Kock, Joery, Rogiers, Vera, van Grunsven, Leo A., Topal, Baki, Pirenne, Jacques, Vankelecom, Hugo, Nevens, Frederik, van den Oord, Joost, Pinzani, Massimo, Roskams, Tania   +20 more
openaire   +7 more sources

Keratin 19 Epithelial Patterns in Cirrhotic Stroma Parallel Hepatocarcinogenesis [PDF]

The American Journal of Pathology, 2011
Cirrhotic septa harbor vessels and inflammatory, fibrogenic, and ductular epithelial cells, collectively referred to as the ductular reaction (DR). Lack of the DR in the stromal compartment around hepatocellular carcinoma (HCC) has been documented; however, the relationship of epithelial keratin 19 (K19) structures to progression of intralesional ...
Jochen K M, Lennerz, William C, Chapman, Elizabeth M, Brunt   +2 more
openaire   +2 more sources

No difference in keratin thickness between inner and outer foreskins from elective male circumcisions in Rakai, Uganda. [PDF]

PLoS ONE, 2012
It has been hypothesized that increased HIV acquisition in uncircumcised men may relate to a more thinly keratinized inner foreskin. However, published data are contradictory and potentially confounded by medical indications for circumcision.
Minh H Dinh, Taha Hirbod, Godfrey Kigozi, Eneniziaogochukwu A Okocha, Gianguido C Cianci, Xiangrong Kong, Jessica L Prodger, Kristina Broliden, Rupert Kaul, David Serwadda, Maria J Wawer, Ronald H Gray, Thomas J Hope   +12 more
doaj   +1 more source

Keratin 19 expression correlates with poor prognosis in breast cancer [PDF]

Molecular Biology Reports, 2014
Breast cancer expression profiling has been used for determining biomarkers. Using gene expression profiles of 2,400 patients we identified keratin 19 (KRT19) as a highly deregulated gene in breast cancer. KRT19 expression is independent of patient race but correlates with disease grade, and ER, PR or HER2 expression.
Kabir, Nuzhat N., Rönnstrand, Lars, Kazi, Julhash U.   +2 more
openaire   +3 more sources