Results 41 to 50 of about 88,954 (294)

Identification of a keratin-associated protein that localizes to a membrane compartment [PDF]

Biochemical Journal, 1994
We describe the characterization of an acidic glycoprotein (molecular mass approximately 85 kDa) that associates with keratin intermediate filaments of ‘simple’-type epithelia. Using a number of anti-keratin monoclonal antibodies, the 85 kDa glycoprotein was identified by co-immunoprecipitation with keratin polypeptides 8 and 18 (K8/18) from the human ...
C F, Chou, C L, Riopel, M B, Omary
openaire   +2 more sources

Epiplakin deficiency aggravates murine caerulein-induced acute pancreatitis and favors the formation of acinar keratin granules.

PLoS ONE, 2014
Epiplakin, a member of the plakin protein family, is exclusively expressed in epithelial tissues and was shown to bind to keratins. Epiplakin-deficient (EPPK-/-) mice showed no obvious spontaneous phenotype, however, EPPK-/- keratinocytes displayed ...
Karl L Wögenstein, Sandra Szabo, Mariia Lunova, Gerhard Wiche, Johannes Haybaeck, Pavel Strnad, Peter Boor, Martin Wagner, Peter Fuchs   +8 more
doaj   +1 more source

Mutational analysis of epidermal and hyperproliferative type I keratins in mild and moderate psoriasis vulgaris patients: a possible role in the pathogenesis of psoriasis along with disease severity

Human Genomics, 2018
Background Mutations in keratin proteins have been vastly associated with a wide array of genodermatoses; however, mutations of keratins in psoriasis have not been fully investigated.
Tamilselvi Elango, Jingying Sun, Caihong Zhu, Fusheng Zhou, Yaohua Zhang, Liangdan Sun, Sen Yang, Xuejun Zhang   +7 more
doaj   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer. [PDF]

, 2011
Progenitor cells are considered an important cell of origin of human malignancies. However, there has not been any single gene that can define mammary bipotential progenitor cells, and as such it has not been possible to use genetic methods to introduce ...
Bu, W, Chamness, GC, Chen, J, Creighton, CJ, Hilsenbeck, SG, Huang, J, Huang, S, Leavitt, AD, Li, Y, Morrison, GD, Roop, DR   +10 more
core   +2 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Identification of Keratin 23 as a Hepatitis C Virus-Induced Host Factor in the Human Liver

Cells, 2019
Keratin proteins form intermediate filaments, which provide structural support for many tissues. Multiple keratin family members are reported to be associated with the progression of liver disease of multiple etiologies.
Volker Kinast, Stefan L. Leber, Richard J. P. Brown, Gabrielle Vieyres, Patrick Behrendt, Constanze Eßbach, Pavel Strnad, Florian W. R. Vondran, Markus Cornberg, Cora Wex, Thomas Pietschmann, Johannes Haybaeck, Daniel Todt, Eike Steinmann   +13 more
doaj   +1 more source

Keratin-associated protein micromaterials for medical and cosmetic applications

Polimery, 2009
Procedure of preparation of keratin associated protein micromaterials from hair, wool and bristle like natural sources has been developed. Procedure involves a combination of chemical activation and enzymatic digestion of natural substrates. Keratin associated proteins could be applied as microscaffolds in medicine and cosmetics.
ANDRZEJ W. LIPKOWSKI, BARBARA GAJKOWSKA, ANNA GRABOWSKA, KATARZYNA KURZEPA   +3 more
openaire   +1 more source

Genetics of Wool and Cashmere Fibre: Progress, Challenges, and Future Research

Animals
Wool (sheep) and cashmere (goat) fibres have unique biological, physical, and chemical properties and these fibres are becoming more important as the demand for natural products increases. However, these complex protein fibres are at times compromised by
Huitong Zhou, Lingrong Bai, Shaobin Li, Wenhao Li, Jiqing Wang, Jinzhong Tao, Jon G. H. Hickford   +6 more
doaj   +1 more source

Regional variation in the flexural properties of the equine hoof wall [PDF]

, 2008
The equine hoof wall is a hard, keratinous structure that transmits forces generated when the hoof connects the ground to the skeleton of the horse. During locomotion the hoof capsule is known to deform, resulting in an inward curvature of the dorsal ...
A M Goodman, Bertram, Bertram, Butler, Dejardin, Douglas, Dyhre-Poulsen, Fraser, Hinterhofer, Jackson, Kasapi, Kasapi, Kasapi, Kasapi, L Haggis, Leach, Lungwitz, Newlyn, Niklas, Reilly, Sokal, Stump, Thomason, Vincent   +23 more
core   +1 more source