Results 211 to 220 of about 62,676,716 (290)

Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production

open access: yesBiotechnology and Bioengineering, Volume 123, Issue 11, Page 3152-3164, November 2026.
ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise   +3 more
wiley   +1 more source

MGP_HNSC32: A H&E Morphology‐Derived 32‐Gene Prognostic Signature in Head and Neck Squamous Cell Carcinoma

open access: yesCancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Head and neck squamous cell carcinoma (HNSC) exhibits substantial molecular and morphological heterogeneity, yet current morphology‐based prognostic models often lack biological interpretability. We developed a transformer‐based computational framework (CTransPath) to virtually predict gene expression directly from hematoxylin and eosin (H&E ...
Di Zhao   +5 more
wiley   +1 more source

First evidence of keratinolytic activity in Simplicillium aogashimaense isolated from wool-pellet-amended soil. [PDF]

open access: yesMicrob Cell Fact
Isembart C   +7 more
europepmc   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

open access: yesClinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1326-1337, November 2026.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries   +8 more
wiley   +1 more source

Lymph Node Regression Improves Prognostic Stratification in Esophageal Squamous Cell Carcinoma Receiving Neoadjuvant Chemoimmunotherapy: A Multicenter Retrospective Cohort Study

open access: yesMedComm, Volume 7, Issue 11, November 2026.
Pathological lymph node regression grading predicts survival after neoadjuvant chemoimmunotherapy. (A) Schematic illustration of the novel five‐tier lymph node regression grading (LNRG) system and representative histopathological images. LNRG 1–4 were defined as follows: LNRG 1, no viable tumor cells observed within the tumor bed; LNRG 2, viable tumor ...
Jian Zheng   +15 more
wiley   +1 more source

Impact of Dupilumab Therapy on Skin Barrier Function in Patients With Moderate‐to‐Severe Atopic Dermatitis: A Phase IV, Non‐Randomized, Open‐Label, Parallel‐Group Clinical Study

open access: yesMedComm, Volume 7, Issue 11, November 2026.
This 16‑week study assessed impact of dupilumab on skin barrier function in patients with moderate‑to‑severe atopic dermatitis (AD). Tape‑stripped stratum corneum samples for multi‑omic profiling, alongside transepidermal water loss measurements, were collected from lesional/non‑lesional AD skin and healthy controls at seven time points.
Taoming Liu   +21 more
wiley   +1 more source

Home - About - Disclaimer - Privacy