Results 191 to 200 of about 57,590 (253)

Synthese und aktivitätsbasierte Proteinprofilierung identifizieren die Aldo‐Keto‐Reduktase 1C3 als Zielprotein der Myxoglucamide

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
Myxoglucamid A – ein neuartiges, aus Myxobakterien isoliertes Glykolipopeptid – wurde erstmals totalsynthetisch hergestellt. Mittels aktivitätsbasierter Proteinprofilierung (ABPP) wurde die Aldo‐Keto‐Reduktase 1C3 (AKR1C3) als primäres Zielprotein in menschlichen Zellen identifiziert.
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Insights into the Maturity of Keratin Byproduct-Based Biofertilizer by UV-Vis, Fourier Transform Infrared Spectroscopy, and Scanning Electron Microscopy Technologies. [PDF]

ACS Omega
Biyada S, Marčiulaitienė E, Boris R, Malaiškienė J, Urbonavičius J.   +4 more
europepmc   +1 more source

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

Angewandte Chemie International Edition, Volume 65, Issue 41, 5 October 2026.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Immunohistochemical study of α-keratin, loricrin, filaggrin-like protein, and transglutaminase-1 expression in orthokeratinized and parakeratinized epithelium of the tongue of domestic goose (Anser anser f. domestica) during embryonic development. [PDF]

Histochem Cell Biol
Skieresz-Szewczyk K, Jackowiak H.
europepmc   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, Volume 13, Issue 55, 5 October 2026.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Bright monomeric fluorescent protein elite-niRFP704 for two-channel near-infrared STED nanoscopy. [PDF]

Proc Natl Acad Sci U S A
Habenstein F, Jensen N, Stumpf D, Chizhik AI, Leutenegger M, Chang J, Fognini A, Qin-Dregely J, Zadeh IE, Kirck LL, Enderlein J, Inamdar K, Hell SW, Jakobs S.   +13 more
europepmc   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, Volume 13, Issue 55, 5 October 2026.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Chemicals of Concern in Chemical Hair Straightening Products: A Scoping Review. [PDF]

Curr Environ Health Rep
Weaver E, Chan M, Edwards L, Zota AR.
europepmc   +1 more source

Chronic Granulomatous Peritonitis From Recurrent Bilateral Ovarian Mature Cystic Teratomas Masquerade as Peritoneal Carcinomatosis

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Although rare, ruptured mature cystic teratoma (MCT) can cause chronic granulomatous peritonitis that mimics peritoneal carcinomatosis. In patients with a history of cystectomy for MCT, careful clinicoradiologic and histopathologic correlation is essential to avoid misdiagnosis and unnecessary aggressive treatment.
Zohre Sadeghian, Joel Cardenas, Kirill Lyapichev, Albert Parlade, Elvia Goez‐Gutierrez, Amir Behdad, Esther Yoon   +6 more
wiley   +1 more source

Case Report: Successful topical simvastatin therapy in a 2-year-old girl with keratin 16-associated palmoplantar epidermal differentiation disorder. [PDF]

Front Pediatr
Zhong Q, Zhang Y, Feng Z, Zhang J, Chen B.   +4 more
europepmc   +1 more source