Results 91 to 100 of about 57,590 (253)

Actomyosin forces trigger a conformational change in desmoplakin within desmosomes

Nature Communications
Desmosomes are essential cell-cell adhesion organelles that enable tension-prone tissues, like the skin and heart, to withstand mechanical stress.
Yinchen Dong, Ahmed Elgerbi, Bin Xie, Yerin Han, Adam V. Kwiatkowski, John S. Choy, Sanjeevi Sivasankar   +6 more
doaj   +1 more source

Age and the means of bypassing stasis are determinants of the intrinsic subtypes of immortalized human mammary epithelial cells

Frontiers in Cell and Developmental Biology, 2015
Based on molecular features, breast cancers are grouped into intrinsic subtypes that have different prognoses and therapeutic response profiles. With increasing age, breast cancer incidence increases, with hormone receptor-positive and other luminal-like
Jonathan K Lee, James C Garbe, Masaru eMiyano, Martha R Stampfer, Mark A LaBarge   +4 more
doaj   +1 more source

Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis

Animal Research and One Health, EarlyView.
Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).
Hao Li, Yuchen He, Yangshuo Hu, Naominggaowa, Huaiqiang Yang, Zhu Meng, Fei Liu, Shiwen Zhang, Yi Jin, Mingxing Chu, Zhangyuan Pan   +10 more
wiley   +1 more source

Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise, Lena‐Marie Eberle, Holger Laux, Kerstin Otte   +3 more
wiley   +1 more source

HERC4 downregulates KRT19 to promote lung adenocarcinoma, migration, invasion and EMT

Translational Oncology
Background: Metastasis is a major cause of treatment failure and poor prognosis in lung adenocarcinoma (LUAD). Epithelial-mesenchymal transition (EMT) plays a crucial role in promoting LUAD metastasis.
Hao-Jia Sun, Ming-Hui Peng, Zi-Yang Feng, Hua Fu, Xue-Wen Liu   +4 more
doaj   +1 more source

Keratins 17 and 19 expression as prognostic markers in oral squamous cell carcinoma

Genetics and Molecular Research, 2015
Five-year survival rates for oral squamous cell carcinoma (OSCC) are 30% and the mortality rate is 50%. Immunohistochemistry panels are used to evaluate proliferation, vascularization, apoptosis, HPV infection, and keratin expression, which are important markers of malignant progression.
Coelho, B. A., Peterle, G. T., Santos, Marcelo dos, Agostini, Lidiane Pignaton, Maia, L. L., Stur, E., Silva, C. V. M., Mendes, Suzanny Oliveira, Almança, Carlos Cesar Jorden, Freitas, Flávia Vitorino, Borçoi, Aline Ribeiro, Archanjo, Anderson Barros, Mercante, A. M. C., Nunes, Fabio Daumas, Carvalho, M. B., Silva, Eloiza Helena Tajara da, Louro, Iuri Drummond, Silva-Conforti, A. M. A   +17 more
openaire   +3 more sources

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

BMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing, Yuhui Yang, Ziyi Zhao, Kai Lv, Yiran Shao, Zhi Zhang, Dong Ma   +6 more
wiley   +1 more source

Periocular keratoacanthoma: A clinicopathologic study and diagnostic challenges

The Pan-American Journal of Ophthalmology
Purpose: Keratoacanthoma (KA) is a cutaneous neoplasm that presents as a rapidly growing tumor on ultraviolet light-exposed skin. It appears as an exophytic, crater-like lesion filled with keratin. In periocular sites, the eyelids are most often affected.
Eduardo Ballalai Bordon, Emily Marcotte, Jacqueline Coblentz, Guilherme Feltrin Barros, Christian El-Hadad, Massimo Mazza, Morgan Yurchuk, Miguel Noel Burnier   +7 more
doaj   +1 more source

Sequence of cDNA coding for human keratin 19 [PDF]

Nucleic Acids Research, 1987
P C, Stasiak, E B, Lane
openaire   +2 more sources

Unveiling the Potential of Metal and Non‐Metal Modified Porous Carbon for the Electrochemical Reduction of CO2

Carbon Energy, EarlyView.
Earth‐abundant metal‐ and non‐metal‐modified porous carbons offer a highly tunable platform for electrochemical CO2 reduction. This review shows how electronic interactions, active‐site coordination, pore architecture, and cooperative catalytic effects jointly govern intermediate stabilization, product selectivity, and device‐relevant CO2RR performance.
Hussein A. Younus, Asma Al Harthi, Mohammed Al Abri, Kamel Eid, Rashid Al Hajri   +4 more
wiley   +1 more source