Results 131 to 140 of about 57,119 (251)

Elevated CO2 and Temperature Alter Grass Pollen's Ability to Modify Transcriptome and Function of the Nasal Epithelium

Allergy, EarlyView.
We exposed human nasal epithelial tissues to pollen from grasses grown under different climate treatments (temperature and CO2). Pollen weakened epithelial tight junctions and altered cytokine‐related gene expression, with similar protein‐level effects.
Tarleena Tossavainen, Tanja Turunen, Maria‐Viola Martikainen, Miisa Kankaanpää, Marjo Malinen, Marjut Roponen   +5 more
wiley   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Keratin 19 regulates cell cycle pathway and sensitivity of breast cancer cells to CDK inhibitors. [PDF]

Sci Rep, 2019
Sharma P, Alsharif S, Bursch K, Parvathaneni S, Anastasakis DG, Chahine J, Fallatah A, Nicolas K, Sharma S, Hafner M, Kallakury B, Chung BM.   +11 more
europepmc   +1 more source

Differential Roles for IL‐4Rα and IL‐13Rα1 in Immune Cell Infiltration and Epithelial Remodeling in Experimental Eosinophilic Gastritis

Allergy, EarlyView.
This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease. including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs.
Anish Dsilva, Shraddha Sharma, Shireen Barakey, Ariel Wagner, Alice Keisar, Tali Bar‐on, Michal Itan, Ariel Munitz   +7 more
wiley   +1 more source

Distinct Skin Penetration and Immune Responses to Ionic and Nanoparticulate Cobalt in Allergic Contact Dermatitis

Allergy, EarlyView.
Cobalt chloride (CoCl2) and cobalt nanoparticles (CoNPs) induce a shared, severity‐dependent inflammatory response in cobalt‐sensitized skin characterized by activation of interferon signaling, inflammatory pathways (TNF/NF‐κβ, IL6‐STAT3), apoptosis/UPR, cell cycle programs, and glycolysis.
Paulina Werner, Martin Schaier, Gabriel Braun, Anneli Julander, Klara Midander, Marlene Isaksson, Gunda Koellensperger, Lukas Wisgrill, Nanna Fyhrquist   +8 more
wiley   +1 more source

The Airway Transcriptome in Type 2 Cytokine Biomarker‐High and ‐Low Severe Asthma

Allergy, EarlyView.
This study distinguishes severe asthma–related airway transcriptomic changes from the effects of high‐dose ICS. Most dysregulated genes in severe asthma show concordance with corticosteroid responses. Corticosteroid‐resistant T2‐high asthma featured T2‐high and epithelial barrier gene upregulation, while T2‐low asthma featured Th1/IL‐17 signatures. ASM,
Jiashu Shen, Rekha Chaudhuri, Stephen Bicknell, Adel H. Mansur, Rahul Shrimanker, Ian D. Pavord, Stephen J. Fowler, Vanessa Brown, Lorcan P. McGarvey, Peter H. Howarth, Sven‐Erik Dahlén, Ian M. Adcock, Nazanin Zounemat‐Kermani, Joseph R. Arron, Liam G. Heaney, David F. Choy, Timothy S. C. Hinks, Emanuele Marchi, Peter Bradding, on behalf of the UK Medical Research Council Refractory Asthma Stratification programme (RASP‐UK)   +19 more
wiley   +1 more source

Heterogeneity of Epigenetic and Epithelial Mesenchymal Transition Marks in Hepatocellular Carcinoma with Keratin 19 Proficiency. [PDF]

Liver Cancer, 2019
Yokomichi N, Nishida N, Umeda Y, Taniguchi F, Yasui K, Toshima T, Mori Y, Nyuya A, Tanaka T, Yamada T, Yagi T, Fujiwara T, Yamaguchi Y, Goel A, Kudo M, Nagasaka T.   +15 more
europepmc   +1 more source

Pathways of Epithelial Barrier Breakdown and Remodeling in Esophageal Organoids by Commonly Used Surfactants

Allergy, EarlyView.
This study shows that SDS and CAPB directly impair esophageal epithelial barrier integrity in primary EoE‐derived models. SDS induces stronger inflammatory, oxidative stress, and keratinization responses than CAPB. Both surfactants promote epithelial remodeling and partial epithelial‐mesenchymal transition (EMT), with CAPB showing a distinct ...
Ozge Ardicli, Duygu Yazici, Huseyn Babayev, Yagiz Pat, Manal Bel Imam, Hang Du, Hassan Melhem, Carina Beha, Laura Buergi, Anja Heider, Juan‐Felipe López, Sena Ardicli, Can Zeyneloğlu, Andrea Kreienbühl, Nino Stocker, Patrick Westermann, Christoph B. Messner, Mübeccel Akdis, Jan Hendrik Niess, Alain Schoepfer, Luc Biedermann, Cezmi A. Akdis, Swiss EoE Cohort Study Group, Patrick Aepli, Luc Biedermann, Ruggero Biral, Carine Blanchard, Lorenzo Botteselle, Simon Buetikofer, Emanuel Burri, Joachim Diebold, Annika Eckhold, Annett Franke, Michèle Frei, Thomas Greuter, Chantal Hasler, Wolfram Jochum, Tanja Kilchmann, Seraina Koller, Andrea Kreienbühl, Fritz Murray, Peter Netzer, Gabrielle Reichhart, Elodie Ristorcelli, Gerhard Rogler, Jean‐Benoit Rossel, Ekaterina Safroneeva, Catherine Saner, Christoph Schlag, Jon‐Duri Senn, Alain Schoepfer, Philipp Schreiner, Christine Sempoux, Dagmar Simon, Hans‐Uwe Simon, Alex Straumann, Sven Trelle, Achim Weber, Niels Willi, Marcel Zwahlen, Willem van de Veen   +60 more
wiley   +1 more source

Impact of Copper Nanoparticles on Keratin 19 (KRT19) Gene Expression in Breast Cancer Subtypes: Integrating Experimental and Bioinformatics Approaches. [PDF]

Int J Mol Sci
Taha S, Sultan A, Aljishi M, Greish K.
europepmc   +1 more source

Cellular characteristics of keratin 19-positive canine hepatocellular tumours explain its aggressive behaviour. [PDF]

Vet Rec Open, 2017
van Sprundel RG, van den Ingh TS, Schotanus BA, van Wolferen ME, Penning LC, Rothuizen J, Spee B.   +6 more
europepmc   +1 more source