The Expression of Keratin 19 in Intervertebral Disc Degeneration and Aging [PDF]
Global Spine Journal, 2016 Introduction Low back pain (LBP) affects 80% of the whole population around the world and causes great social-economic burden. Intervertebral disc (IVD) degenerates with aging and is a major contribution to LBP.
Fengjuan Lv +2 more
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Clinico-Radio-Pathological and Molecular Features of Hepatocellular Carcinomas with Keratin 19 Expression [PDF]
Liver Cancer, 2020 Hepatocellular carcinoma (HCC) is a heterogeneous neoplasm, both from the molecular and histomorphological aspects. One example of heterogeneity is the expression of keratin 19 (K19) in a subset (4–28%) of HCCs. The presence of K19 expression in HCCs has
Hyungjin Rhee +2 more
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Keratin 19 (Krt19) is a novel marker gene for epicardial cells [PDF]
Frontiers in GeneticsEpicardial cells regulate heart growth by secreting numerous growth factors and undergoing lineage specification into other cardiac lineages. However, the lack of specific marker genes for epicardial cells has hindered the understanding of this cell type
Juan Xu, Yiting Deng, Guang Li
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Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer [PDF]
BMC Molecular and Cell Biology, 2023 Background Heterogeneous nuclear ribonucleoprotein K (HNRNPK) regulates pre-mRNA processing and long non-coding RNA localization in the nucleus. It was previously shown that shuttling of HNRNPK to the cytoplasm promotes cell proliferation and cancer ...
Arwa Fallatah +10 more
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Characterization of in vivo keratin 19 phosphorylation on tyrosine-391. [PDF]
PLoS ONE, 2010 Keratin polypeptide 19 (K19) is a type I intermediate filament protein that is expressed in stratified and simple-type epithelia. Although K19 is known to be phosphorylated on tyrosine residue(s), conclusive site-specific characterization of these ...
Qin Zhou +7 more
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Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells [PDF]
Cell Adhesion & Migration, 2021 A cytoskeletal protein keratin 19 (K19) is highly expressed in breast cancer but its effects on breast cancer cell mechanics are unclear. In MCF7 cells where K19 expression is ablated, we found that K19 is required to maintain rounded epithelial-like ...
Sarah Alsharif +12 more
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Time-Course Changes of Serum Keratin Concentrations after Liver Transplantation: Contrasting Results of Keratin-18 and Keratin-19 Fragments [PDF]
Case Reports in Hepatology, 2020 Objective. Under normal conditions, adult hepatocytes express only keratin-8 (K8) and keratin-18 (K18), whereas cholangiocytes also express K19. In this study, we delineate the pattern of normal time-course changes in serum K19 and K18 levels after liver
Cristina Macía +7 more
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Keratin 19 is a potential diagnostic and prognostic biomarker in pancreatic adenocarcinoma. [PDF]
Medicine (Baltimore)This study aimed to evaluate Keratin 19 (KRT19) as a potential prognostic biomarker for the diagnosis and prognosis of pancreatic adenocarcinoma (PAAD). Using data from The Cancer Genome Atlas and the Gene Expression Omnibus, we analyzed KRT19 expression in PAAD tissues and identified differentially expressed genes associated with KRT19. Gene ontology (
He L, Li L, Chen Z.
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Signal peptide-independent secretion of keratin-19 by pancreatic cancer cells. [PDF]
Proc Natl Acad Sci U S AAbstract The exclusion of T cells causes immune escape of pancreatic ductal adenocarcinoma (PDA). T cell exclusion is mediated by the interaction between CXCR4 on T cells and its ligand, CXCL12, which is complexed to keratin-19 (KRT19) on the surface of PDA cells.
Moresco P +9 more
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Serum keratin 19 (CYFRA21-1) links ductular reaction with portal hypertension and outcome of various advanced liver diseases [PDF]
BMC Medicine, 2020 Background Keratins (Ks) represent tissue-specific proteins. K18 is produced in hepatocytes while K19, the most widely used ductular reaction (DR) marker, is found in cholangiocytes and hepatic progenitor cells.
Karim Hamesch +16 more
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