Results 251 to 260 of about 5,007,555 (282)

Analysis of Keratin Polypeptides 8 and 19 Variants in Inflammatory Bowel Disease

Clinical Gastroenterology and Hepatology, 2007
Keratin-8 (KRT8)-null mice develop spontaneous colitis and predisposition to liver injury. Human studies show that some KRT8 variants predispose to end-stage liver disease and progression and suggest that such variants might associate with UC or CD. We asked whether mutations in KRT8 or KRT19, the major intestinal keratins, are associated with UC/CD ...
Guo-Zhong, Tao, Pavel, Strnad, Qin, Zhou, Ahmad, Kamal, Leilei, Zhang, Nahid D, Madani, Subra, Kugathasan, Steven R, Brant, Judy H, Cho, M Bishr, Omary, Richard H, Duerr   +10 more
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Keratin 19 in the adult human prostate: tissue and cell culture studies

Cell and Tissue Research, 1996
Keratin 19 is found primarily in simple epithelia. In mammary epithelia, keratin 19 was localized to a subset of luminal cells, suggesting that keratin 19-negative cells may be the proliferative compartment of the secretory cell lineage. The structural and functional similarities of prostate and breast led us to examine keratin 19 expression in the ...
D M, Peehl, R G, Sellers, J E, McNeal
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The mouse keratin 19-encoding gene: sequence, structure and chromosomal assignment

Gene, 1990
Keratin 19 (K19) is synthesized mainly in embryonic and adult simple epithelia, but has also been found in stratified epithelia as well. K19 is the smallest known keratin and is remarkable in that, contrary to all other keratins, it does not have a designated partner for the formation of filaments, implying that regulation of its expression is ...
Lussier, M, Filion, M, Compton, J G, Nadeau, J H, Lapointe, L, Royal, A   +5 more
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Keratin 19-like immunoreactivity in receptor cells of mammalian taste buds

Chemical Senses, 1994
Three monoclonal antibodies, 4.62, LP2K and 170.2.14, were used to evaluate keratin 19-like immunoreactivity in gustatory epithelia. Keratin 19-like immunoreactivity was restricted to the intragemmal cells for all types of mammalian taste buds examined.
L, Wong, B, Oakley, A, Lawton, Y, Shiba
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Immunohistochemical expression of keratins 8 and 19 in odontogenic cysts and tumors

Journal of Cranio-Maxillary Diseases, 2015
Objective: Cytokeratins (CKs) are integral components in the formation of enamel, dentin and/or cemental matrix and their subsequent mineralization. K8 and K19 are known to be chemically homologous during the formation of tooth structures. This feature is rather unique and is expressed across the milieu of odontogenic tissues in the physiological and ...
VenkateshV Kamath, Komali Yarlagadda, Krishnanand Satelur   +2 more
openaire   +1 more source

Unexpected Low Bone Mass Induced by Global Deletion of Keratin 18 But Not Keratin 19 in Mice

Physiology
Work from our lab has investigated the role of the cytoskeleton in osteoblasts and osteocytes. Our prior work has shown a role for a subset of post-translationally modified tubulin in the osteocyte response to mechanical stimuli and an unexpected role for the type IV intermediate
Philippa Murray, Heather Buck, Katrina LeBlanc, Saimai Chatree, Jenna Leser, Sushrut Pathy, Robert Bloch, Joseph Stains   +7 more
openaire   +1 more source

Keratin 14 protein in cultured nonparenchymal rat hepatic epithelial cells: Characterization of keratin 14 and keratin 19 as antigens for the commonly used mouse monoclonal antibody OV‐6

Molecular Carcinogenesis, 1993
AbstractWe have recently reported that cell lines of nonparenchymal origin isolated from rat liver and pancreas, which have been suggested to be the progeny of a facultative stem cell compartment in vivo, express an unusual combination of keratins (K).
H C, Bisgaard, D C, Parmelee, H A, Dunsford, S, Sechi, S S, Thorgeirsson   +4 more
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The keratin 19 promoter is potent for cell-specific targeting of genes in transgenic mice

Gastroenterology, 2001
Keratins are intermediate filaments that are critical in cytoskeletal organization. Their roles in cellular processes are underscored by inherited human diseases in which germline mutations of keratins are found, as well as by transgenic and knockout mouse models that recapitulate those diseases.
F H, Brembeck, J, Moffett, T C, Wang, A K, Rustgi   +3 more
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Retinoic acid mediates post-transcriptional regulation of keratin 19 mrna levels

Journal of Cell Science, 1993
ABSTRACT Stratified squamous epithelia have been shown to preferentially express a site-specific pattern of keratin intermediate filaments. Retinoic acid (RA) is known to modulate expression of the basal cell keratins K19 and K5. Expression of these genes is dependent on extracellular RA concentration.
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Expression of keratin 19 in a culture of human epidermal keratinocytes

Doklady Biological Sciences, 2006
E A, Vorotelyak, E S, Cheremnykh, A V, Vasil'ev, V V, Terskikh   +3 more
openaire   +2 more sources