Results 221 to 230 of about 55,959 (251)

Analysis of Keratin Polypeptides 8 and 19 Variants in Inflammatory Bowel Disease

Clinical Gastroenterology and Hepatology, 2007
Keratin-8 (KRT8)-null mice develop spontaneous colitis and predisposition to liver injury. Human studies show that some KRT8 variants predispose to end-stage liver disease and progression and suggest that such variants might associate with UC or CD. We asked whether mutations in KRT8 or KRT19, the major intestinal keratins, are associated with UC/CD ...
Guo-Zhong, Tao, Pavel, Strnad, Qin, Zhou, Ahmad, Kamal, Leilei, Zhang, Nahid D, Madani, Subra, Kugathasan, Steven R, Brant, Judy H, Cho, M Bishr, Omary, Richard H, Duerr   +10 more
openaire   +2 more sources

Unexpected Low Bone Mass Induced by Global Deletion of Keratin 18 But Not Keratin 19 in Mice

Physiology
Work from our lab has investigated the role of the cytoskeleton in osteoblasts and osteocytes. Our prior work has shown a role for a subset of post-translationally modified tubulin in the osteocyte response to mechanical stimuli and an unexpected role for the type IV intermediate
Philippa Murray, Heather Buck, Katrina LeBlanc, Saimai Chatree, Jenna Leser, Sushrut Pathy, Robert Bloch, Joseph Stains   +7 more
openaire   +1 more source

Immunohistochemical expression of keratins 8 and 19 in odontogenic cysts and tumors

Journal of Cranio-Maxillary Diseases, 2015
Objective: Cytokeratins (CKs) are integral components in the formation of enamel, dentin and/or cemental matrix and their subsequent mineralization. K8 and K19 are known to be chemically homologous during the formation of tooth structures. This feature is rather unique and is expressed across the milieu of odontogenic tissues in the physiological and ...
VenkateshV Kamath, Komali Yarlagadda, Krishnanand Satelur   +2 more
openaire   +1 more source

Keratin 14 protein in cultured nonparenchymal rat hepatic epithelial cells: Characterization of keratin 14 and keratin 19 as antigens for the commonly used mouse monoclonal antibody OV‐6

Molecular Carcinogenesis, 1993
AbstractWe have recently reported that cell lines of nonparenchymal origin isolated from rat liver and pancreas, which have been suggested to be the progeny of a facultative stem cell compartment in vivo, express an unusual combination of keratins (K).
H C, Bisgaard, D C, Parmelee, H A, Dunsford, S, Sechi, S S, Thorgeirsson   +4 more
openaire   +2 more sources

Identification of Epithelial Stem Cells In Vivo and In Vitro Using Keratin 19 and BrdU

2009
Progress in the identification of skin stem cells and the improvement of culture methods open the possibility to use stem cells in regenerative medicine. Based on their quiescent nature, the development of label retention assays allowed the localization of skin stem cells in the bulge region of the pilosebaceous units and in the bottom of rete ridges ...
Germain, Lucie, Larouche, Danielle, Paquet, Claudie, Simard-Bisson, Carolyne, Lavoie, Amélie   +4 more
openaire   +3 more sources

The keratin 19 promoter is potent for cell-specific targeting of genes in transgenic mice

Gastroenterology, 2001
Keratins are intermediate filaments that are critical in cytoskeletal organization. Their roles in cellular processes are underscored by inherited human diseases in which germline mutations of keratins are found, as well as by transgenic and knockout mouse models that recapitulate those diseases.
F H, Brembeck, J, Moffett, T C, Wang, A K, Rustgi   +3 more
openaire   +2 more sources

Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization

Journal of Cell Science, 2007
Intermediate filaments, composed of desmin and of keratins, play important roles in linking contractile elements to each other and to the sarcolemma in striated muscle. We examined the contractile properties and morphology of fast-twitch skeletal muscle from mice lacking keratin 19.
Michele R, Stone, Andrea, O'Neill, Richard M, Lovering, John, Strong, Wendy G, Resneck, Patrick W, Reed, Diana M, Toivola, Jeanine A, Ursitti, M Bishr, Omary, Robert J, Bloch   +9 more
openaire   +2 more sources

Retinoic acid mediates post-transcriptional regulation of keratin 19 mrna levels

Journal of Cell Science, 1993
ABSTRACT Stratified squamous epithelia have been shown to preferentially express a site-specific pattern of keratin intermediate filaments. Retinoic acid (RA) is known to modulate expression of the basal cell keratins K19 and K5. Expression of these genes is dependent on extracellular RA concentration.
openaire   +2 more sources

Recent advances in keratin for biomedical applications

Advances in Colloid and Interface Science, 2023
Jiang Yuan, Yushuang Shang
exaly  

Expression of keratin 19 in a culture of human epidermal keratinocytes

Doklady Biological Sciences, 2006
E A, Vorotelyak, E S, Cheremnykh, A V, Vasil'ev, V V, Terskikh   +3 more
openaire   +2 more sources