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Ugeskrift for Læger
Keratinocyte cancer (KC) cases have risen by 172% in Denmark over the last decade and the lifetime risk of developing KC is at least 22%. This highlights the need for innovative strategies in KC prevention, diagnosis, and treatment. To reduce incidence, new prevention methods are crucial.
Emilie Westerlin, Kjeldsen +12 more
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Keratinocyte cancer (KC) cases have risen by 172% in Denmark over the last decade and the lifetime risk of developing KC is at least 22%. This highlights the need for innovative strategies in KC prevention, diagnosis, and treatment. To reduce incidence, new prevention methods are crucial.
Emilie Westerlin, Kjeldsen +12 more
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Cell Biology International, 1995
ABSTRACTKeratinocyte growth factor (KGF) is a member of the heparin‐binding fibroblast growth factor family (FGF‐7) with a distinctive pattern of target‐cell specificity. Studies performed in cell culture suggested that KGF was mitogenically active only on epithelial cells, albeit from a variety of tissues. In contrast, KGF was produced solely by cells
Jeffrey S. Rubin +10 more
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ABSTRACTKeratinocyte growth factor (KGF) is a member of the heparin‐binding fibroblast growth factor family (FGF‐7) with a distinctive pattern of target‐cell specificity. Studies performed in cell culture suggested that KGF was mitogenically active only on epithelial cells, albeit from a variety of tissues. In contrast, KGF was produced solely by cells
Jeffrey S. Rubin +10 more
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Expert Opinion on Biological Therapy, 2009
Mucositis occurs in over 90% of patients undergoing stem cell transplantation for hematological malignancies. It is associated with significant morbidity in the form of pain, dysphagia and decreased oral intake, as well as mortality. Palifermin is a recombinant keratinocyte growth factor that has been shown to be effective in decreasing the incidence ...
Uzma, Athar, Teresa C, Gentile
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Mucositis occurs in over 90% of patients undergoing stem cell transplantation for hematological malignancies. It is associated with significant morbidity in the form of pain, dysphagia and decreased oral intake, as well as mortality. Palifermin is a recombinant keratinocyte growth factor that has been shown to be effective in decreasing the incidence ...
Uzma, Athar, Teresa C, Gentile
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Keratinocyte Superoxide Generation
Free Radical Biology and Medicine, 1998We have demonstrated using the reduction of cytochrome c, that the keratinocyte cell line H357 generates superoxide at significant rates (8.36 nmol/h/10[6] cells). The rate of superoxide release decreased as the cells reached confluence. Superoxide production was increased more than twofold following preincubation with IL-1beta, or by the addition of ...
Turner, CP, Toye, AM, Jones, OTG
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Keratinocyte Transient Transfections
2004The goal of this chapter is to give the reader a concise and easy-to-follow guide to proven transient transfection techniques for primary strains and continuous lines of keratinocytes. The emphasis is on readily available and inexpensive resources that also allow for repeatability and adaptability to scale, experimental conditions, and sample ...
Anthony M, Flores, Brian J, Aneskievich
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Acta Pathologica Microbiologica Scandinavica Series A :Pathology, 1987
The surface structure of 11–12 days old cultures from biopsies of normal skin and uninvolved psoriatic skin was investigated by scanning electron microscopy. The keratinocytes formed flat, thin, and well‐organized layers of elongated, tightly apposed cells.
E H, Nielsen +4 more
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The surface structure of 11–12 days old cultures from biopsies of normal skin and uninvolved psoriatic skin was investigated by scanning electron microscopy. The keratinocytes formed flat, thin, and well‐organized layers of elongated, tightly apposed cells.
E H, Nielsen +4 more
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Premalignant keratinocytic neoplasms
Journal of the American Academy of Dermatology, 1996Premalignant keratinocytic keratoses are common, especially in pale-complected persons in whom they appear most often as an actinic keratosis. Although the actinic keratosis has a very low malignant potential, arsenic, tar, thermal, scar, reactional, and radiation keratoses may be more clinically aggressive.
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Veterinary Immunology and Immunopathology, 2002
The skin has long been recognized as a major producer of cytokines, but the keratinocyte as principal epidermal cell has received less attention as potential source and target of cytokines. Nevertheless, keratinocytes produce a plethora of cytokines including interleukin (IL)-1, -6, -7, -8, -10, -12, -15, -18, and -20, and tumor necrosis factor alpha ...
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The skin has long been recognized as a major producer of cytokines, but the keratinocyte as principal epidermal cell has received less attention as potential source and target of cytokines. Nevertheless, keratinocytes produce a plethora of cytokines including interleukin (IL)-1, -6, -7, -8, -10, -12, -15, -18, and -20, and tumor necrosis factor alpha ...
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Keratinocyte Carcinogenesis: Introduction
1993Skin keratinocytes may give rise to a broad variety of benign and malignant epithelial tumors. Among these, basal cell carcinoma and squamous cell carcinoma are the most frequent. Up to 60% of squamous cell carcinomas are preceded by precancerous lesions, mostly by actinic keratoses and rarely by Bowen’s disease.
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Archives of Dermatology, 1993
Gene therapy is currently being used in clinical trials to treat a variety of diseases. In keratinocyte gene therapy, the gene that will correct the disease by expressing the normal protein or enzyme is inserted and expressed in keratinocytes. Keratinocytes have significant potential, as a target cell of gene therapy, in the treatment of both systemic ...
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Gene therapy is currently being used in clinical trials to treat a variety of diseases. In keratinocyte gene therapy, the gene that will correct the disease by expressing the normal protein or enzyme is inserted and expressed in keratinocytes. Keratinocytes have significant potential, as a target cell of gene therapy, in the treatment of both systemic ...
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