Results 81 to 90 of about 28,856 (299)

Marcadores de hiperproliferação na epiderme do meato acústico externo Hyperproliferation markers in ear canal epidermis

Brazilian Journal of Otorhinolaryngology, 2010
Vários estudos envolvendo métodos imunoistoquímicos para avaliação da epiderme do meato acústico externo já foram realizados com os mais diversos objetivos.
João Daniel Caliman e Gurgel, Siqueira Barbosa Pereira, Adriana Leal Alves, Fernando Quintanilha Ribeiro   +3 more
doaj   +1 more source

Keratin K15 as a Biomarker of Epidermal Stem Cells [PDF]

, 2013
Keratin 15 (K15) is type I keratin protein co-expressed with the K5/K14 pair present in the basal keratinocytes of all stratified epithelia. Although it is a minor component of the cytoskeleton with a variable expression pattern, nonetheless its ...
Abbas, Abbas, Ahmad Waseem, Amrita Bose, Bickenbach, Bickenbach, Biddle, Bieniek, Bloor, Bose, Carr, Choi, Clayton, Cotsarelis, Coulombe, Garza, Geiger, Gemenetzidis, Ghadially, Ghali, Hall, Ian Mackenzie, Inoue, Jackson, Jaks, Jih, Jonkman, Kose, Lajtha, Lavker, Leube, Liu, Lloyd, Lyle, Ma, Mackenzie, Mackenzie, Mascre, Michel, Moll, Morris, Morris, Muy-Teck Teh, Myatt, Ohyama, Patel, Peters, Pontiggia, Porter, Potten, Radoja, Rugg, Rugg, Ryle, Sakamoto, Snippert, Tang, Teh, Tompkins, Trempus, Troy, Wang, Waseem, Watt, Webb, Werner, Whitbread, Wierstra, Wobus, Xie, Zhan   +70 more
core   +2 more sources

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Evolutionary origin of Hoxc13-dependent skin appendages in amphibians

Nature Communications
Cornified skin appendages, such as hair and nails, are major evolutionary innovations of terrestrial vertebrates. Human hair and nails consist largely of special intermediate filament proteins, known as hair keratins, which are expressed under the ...
Marjolein Carron, Attila Placido Sachslehner, Munevver Burcu Cicekdal, Inge Bruggeman, Suzan Demuynck, Bahar Golabi, Elfride De Baere, Wim Declercq, Erwin Tschachler, Kris Vleminckx, Leopold Eckhart   +10 more
doaj   +1 more source

Epithelial Keratins Modulate cMet Expression and Signaling and Promote InlB-Mediated Listeria monocytogenes Infection of HeLa Cells

Frontiers in Cellular and Infection Microbiology, 2018
The host cytoskeleton is a major target for bacterial pathogens during infection. In particular, pathogens usurp the actin cytoskeleton function to strongly adhere to the host cell surface, to induce plasma membrane remodeling allowing invasion and to ...
Rui Cruz, Rui Cruz, Rui Cruz, Isabel Pereira-Castro, Isabel Pereira-Castro, Maria T. Almeida, Maria T. Almeida, Alexandra Moreira, Alexandra Moreira, Alexandra Moreira, Didier Cabanes, Didier Cabanes, Sandra Sousa, Sandra Sousa   +13 more
doaj   +1 more source

Proteomic analysis of skin invasion by blood fluke larvae. [PDF]

, 2008
BackgroundDuring invasion of human skin by schistosome blood fluke larvae (cercariae), a multicellular organism breaches the epidermis, basement membrane, and dermal barriers of skin.
Braschi, Simon, Debnath, Moumita, Hansell, Elizabeth, Ingram, Jessica, Lim, KC, McKerrow, James H, Medzihradszky, Katalin F, Sajid, Mohammed   +7 more
core   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Identification of presumed pathogenic KRT3 and KRT12 gene mutations associated with Meesmann corneal dystrophy. [PDF]

, 2015
PurposeTo report potentially pathogenic mutations in the keratin 3 (KRT3) and keratin 12 (KRT12) genes in two individuals with clinically diagnosed Meesmann corneal dystrophy (MECD).MethodsSlit-lamp examination was performed on the probands and available
Aldave, Anthony J, Chen, Judy L, Chung, Duk-Won D, Deng, Sophie X, Frausto, Ricardo F, Gee, Jessica A, Gee, Katherine M, Lin, Benjamin R   +7 more
core   +1 more source

Monoallelic Mutations in the Translation Initiation Codon of KLHL24 Cause Skin Fragility [PDF]

, 2016
The genetic basis of epidermolysis bullosa, a group of genetic disorders characterized by the mechanically induced formation of skin blisters, is largely known, but a number of cases still remain genetically unsolved.
Boerries, Melanie, Busch, Hauke, Castiglia, Daniele, Hannula-Jouppi, Katariina, Has, Cristina, Hausser, Ingrid, He, Yinghong, Heikkilä, Hannele, Kiritsi, Dimitra, Leppert, Juna, Maier, Kristin, Schwieger-Briel, Agnes, Tasanen, Kaisa, Theiler, Martin, Weibel, Lisa, Zambruno, Giovanna   +15 more
core   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source