Results 51 to 60 of about 4,105 (205)

Thalamic involvement in a patient with kernicterus

open access: yes, 2002
We report the MR imaging findings of a 16-month-old boy with dyskinetic cerebral palsy resulting from kernicterus. T2-weighted images showed symmetric bilateral hyperintensity in the thalamus in addition to the globus ...

core   +1 more source

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

open access: yesAdvanced Science, Volume 13, Issue 25, 4 May 2026.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li   +8 more
wiley   +1 more source

Evidence Suggests There Was Not a “Resurgence” of Kernicterus in the 1990s

open access: yes, 2011
BACKGROUND: Although some have suggested that kernicterus disappeared in the United States in the 1970s to 1980s and dramatically reappeared in the 1990s, population-based data to support such a resurgence are lacking.
Jordan C. Brooks   +4 more
core   +1 more source

Role of COHb Level in Newborns with ABO Blood Group Incompatibility in Predicting Newborn Jaundice Risk [PDF]

open access: yesForbes Tıp Dergisi
Objective: Neonates with hyperbilirubinemia are at risk of brain damage, and at least two-thirds of neonates show clinical signs of jaundice in the first week of life.
Kazım DARKA, Şahin TAKCI
doaj   +1 more source

CRIGLER- NAJJAR SYNDROME – CASE REPORT

open access: yesSlovenska pediatrija, 2022
Crigler-Najjar syndrome is a rare genetic disorder that causes severe unconjugated hyperbilirubinaemia. The syndrome is caused by a mutation in the UGT1A1 gene, which results in a deficiency or complete lack of the UGT1A1 enzyme, which is responsible for
Anja Šelih, Manca Velkavrh
doaj   +1 more source

Improved bilirubin reduction with therapeutic plasma exchange and haemoperfusion in a dog with immune‐mediated haemolytic anaemia

open access: yesVeterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 6‐year‐old spayed female Golden Retriever mix was diagnosed with immune‐mediated haemolytic anaemia. Initial treatments included immunosuppression and blood transfusions. With acute mentation decline and rapid increase in serum bilirubin, therapeutic plasma exchange (TPE) was initiated.
Natasha S. Yeh   +2 more
wiley   +1 more source

Studies in kernicterus. I. The protein binding of bilirubin

open access: yes, 1959
The yellow staining of basal ganglia (kernic-terus) in some jaundiced newborn infants has been recognized for many years (1). The as-sociation between serum bilirubin concentration and kernicterus (2, 3), the isolation of bilirubin from kernicteric ...
B. Odell, Gerard B. Odell
core   +1 more source

Exchange Transfusion Trends and Risk Factors for Extreme Neonatal Hyperbilirubinemia over 10 Years in Shiraz, Iran [PDF]

open access: yesIranian Journal of Medical Sciences
Background: Exchange transfusion (ET) is an effective treatment for acute bilirubin encephalopathy and extreme neonatal hyperbilirubinemia (ENH). It can reduce mortality and morbidity.
Fariba Hemmati   +4 more
doaj   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

open access: yesBiological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning   +19 more
wiley   +1 more source

Kernicterus in a Neonatal Foal

open access: yes, 2007
A 5-day-old Thoroughbred foal was submitted to the necropsy service at the University of Kentucky Livestock Disease Diagnostic Center. The foal had a clinical history of seizure activity and severe icterus.
Alan T. Loynachan   +2 more
core   +1 more source

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