Results 71 to 80 of about 4,601 (161)

Bile bilirubin pigment analysis in disorders of bilirubin metabolism in early infancy [PDF]

, 2001
BACKGROUNDEarly and accurate diagnosis of Crigler-Najjar syndrome, which causes prolonged unconjugated hyperbilirubinaemia in infancy, is important, as orthotopic liver transplantation is the definitive treatment.
M A Preece, McKiernan, P.J., Kelly, D.A., P J McKiernan, Kelly, Deirdre, B Burchell, Clarke, Douglas, Burchell, B, Lee, W. S., Beath, Susan, Baty, D, Clarke, D. J., Preece, M.A., Burchell, B., McKiernan, P. J., Lee, Way Seah, S V Beath, Clarke, DJ, D J Clarke, Clarke, D.J., Preece, Mary, Lee, WS, D Baty, W S Lee, Lee, W S, Beath, S.V., D A Kelly, Baty, D., Preece, M. A., Beath, S. V., McKiernan, Patrick, Kelly, D. A.   +31 more
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Kernicterus associated with hereditary spherocytosis and UGT1A1 promoter polymorphism.

, 2006
INTRODUCTION: An apparent re-emergence of kernicterus has been recently reported, with some cases occurring in otherwise healthy breastfed newborn.METHODS: We describe a case of kernicterus in a term Caucasian newborn.RESULTS: An exceptional polymorphism
D'Apolito M, Marrone A, Ferrari F, FERRARI, Fabrizio, Lugli L, Iolascon A., Gargano G, Berardi A, IOLASCON, ACHILLE   +8 more
core   +1 more source

Magnetic resonance imaging of the brain in children with chronic kernicterus

, 2006
Advances in perinatal monitoring and early treatment for hyperbilirubinemia in high-risk patients have greatly reduced the incidence of kernicterus. Findings on MRI in patients with kernicterus are characteristic.
Atalar, Mehmet H., Buyakayhan, Derya, Icagosioglu, Dilara   +2 more
core   +1 more source

Brain magnetic resonance imaging and magnetic resonance spectroscopy findings of children with kernicterus

, 2015
Background: The term kernicterus, or bilirubin encephalopathy, is used to describe pathological bilirubin staining of the basal ganglia, brain stem, and cerebellum, and is associated with hyperbilirubinemia.
Sarı, Sahabettin, Yavuz, Alpaslan, Batur, Aabdussamet, BATUR, Abdussamet, Caksen, Huseyin, Bora, Aydın, SARı, S, CAKSEN, H   +7 more
core   +1 more source

A novel newborn rat kernicterus model created by injecting a bilirubin solution into the cisterna magna.

PLoS ONE, 2014
BackgroundKernicterus still occurs around the world; however, the mechanism of bilirubin neurotoxicity remains unclear, and effective treatment strategies are lacking.
Sijie Song, Ying Hu, Xianfang Gu, Feifei Si, Ziyu Hua   +4 more
doaj   +1 more source

Bilirubin encephalopathy (kernicterus) in an adult cat

, 2019
Case summary An adult cat presented with neurological signs and marked icterus. Clinical pathology tests detected increased serum alkaline phosphatase levels, as well as alanine aminotransferase, total bilirubin, unconjugated bilirubin and conjugated ...
Maria C Andrade, Ágna F Santos, Raquel S Ferreira, Willian HM Santos, Matheus VL Moreira, Luís HG Saraiva, Letícia B Oliveira, Roselene Ecco   +7 more
core   +1 more source

Neurological complications of neonatal hyperbilirubinemia in Eastern India

Annals of Medical Science and Research
Background: Neonatal hyperbilirubinemia (NH) affects up to 60%–80% of term and near-term infants and, when severe or delayed in treatment, can progress to acute bilirubin encephalopathy or permanent kernicterus.
Shatadip Chakraborty, Joydeep Mukherjee, Jayanta Ghosal   +2 more
doaj   +1 more source

Cerebellar Symptoms in Crigler-Najjar Type I Disease

Pediatric Neurology Briefs, 1992
Three children with Crigler-Najjar (CN) type I disease who had cerebellar symptoms as the initial manifestation of kernicterus are reported from the Hopital Antoine Beclere, Clamart Cedex, France.
J Gordon Millichap
doaj   +1 more source

Promoterless gene targeting without nucleases rescues lethality of a Crigler‐Najjar syndrome mouse model

EMBO Molecular Medicine, 2017
Crigler‐Najjar syndrome type I (CNSI) is a rare monogenic disease characterized by severe neonatal unconjugated hyperbilirubinemia with a lifelong risk of neurological damage and death. Liver transplantation is the only curative option, which has several
Fabiola Porro, Giulia Bortolussi, Adi Barzel, Alessia De Caneva, Alessandra Iaconcig, Simone Vodret, Lorena Zentilin, Mark A Kay, Andrés F Muro   +8 more
doaj   +1 more source

Maternal Empowerment - An Underutilized Strategy to Prevent Kernicterus?

, 2017
BACKGROUND: Kernicterus is a common cause of death and morbidity in many Low- Middle-income Countries (LMICs) and still occurs in affluent nations. In either case, the immediate cause is delayed treatment of severe hyperbilirubinemia.
Watchko, Jon F, Shapiro, Steven, Wennberg, Richard P   +2 more
core   +1 more source