Results 101 to 110 of about 345,134 (373)
The effects of memantine on prepulse inhibition. [PDF]
, 2009 Reduced prepulse inhibition (PPI) of startle provides evidence of deficient sensorimotor gating in several disorders, including schizophrenia. The role of NMDA neurotransmission in the regulation of PPI is unclear, due to cross-species differences in the
Bergsma, F +4 more
core +2 more sources
GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions.
Journal of Clinical Investigation, 2019 A single sub-anesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces rapid and sustained antidepressant actions in depressed patients, addressing a major unmet need for the treatment of mood disorders.
Danielle M. Gerhard +11 more
semanticscholar +1 more source
The role of dissociation in ketamine’s antidepressant effects
Nature Communications, 2020 Ketamine produces immediate antidepressant effects and has inspired research into next-generation treatments. Ketamine also has short term dissociative effects, in which individuals report altered consciousness and perceptions of themselves and their ...
E. Ballard, C. Zarate
semanticscholar +1 more source
3D‐Printed Gastrointestinal Stents: In Vivo Evaluation in a Swine Small Bowel Perforation Model
Advanced Healthcare Materials, EarlyView.Gastrointestinal fistulae and perforations can lead to severe complications including sepsis and patient death. In this work, the efficacy of 3D‐printed gastrointestinal stents composed of poly‐lactic‐acid (PLA) was evaluated in an in vivo swine model.
Gweniviere Capron +9 more
wiley +1 more source
Application of Ketamine in Pain Management and the Underlying Mechanism
Pain Research and Management, 2023 Since ketamine was approved by the FDA as an intravenous anesthetic, it has been in clinical use for more than 50 years. Apart from its anesthetic effects, ketamine is one of the few intravenous anesthetics with potent analgesic properties.
Xiaofan Ma, Jia Yan, Hong Jiang
doaj +1 more source
Ketamine and the Future of Rapid-Acting Antidepressants.
Annual Review of Clinical Psychology, 2021 The therapeutic onset of traditional antidepressants is delayed by several weeks, and many depressed patients fail to respond to treatment altogether.
L. Riggs, T. Gould
semanticscholar +1 more source
Interactions of Interaural Time and Level Differences in Spatial Hearing with Cochlear Implants
Advanced Science, EarlyView.Differences in timing (ΔT) are weighted heavily compared to differences in loudness (ΔL) in binaural hearing with cochlear implants. Abstract Normally hearing humans can localize sound sources quite accurately, with minimum audible angles as small as 1°. To achieve this, these auditory pathways combine information from multiple acoustic cues, including
Sarah Buchholz +3 more
wiley +1 more source
Ketamine Modulates Zic5 Expression via the Notch Signaling Pathway in Neural Crest Induction
Frontiers in Molecular Neuroscience, 2018 Ketamine is a potent dissociative anesthetic and the most commonly used illicit drug. Many addicts are women at childbearing age. Although ketamine has been extensively studied as a clinical anesthetic, its effects on embryonic development are poorly ...
Yu Shi +13 more
doaj +1 more source
Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva +28 more
wiley +1 more source
S-ketamine and intranasal application: alternatives for the castration of male suckling piglets?
BMC Veterinary Research, 2021 Background The intramuscular injection of ketamine and azaperone was proposed as a suitable anaesthesia for male suckling piglets for surgical castration.
Sabrina Becker +4 more
doaj +1 more source