Results 121 to 130 of about 345,134 (373)

The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep

Advanced Science, EarlyView.
Sleep is associated with a sensory disconnection whose mechanisms remain elusive. Large neuronal population recordings in the auditory cortex revealed that, in NREM sleep, the neural code for sounds is highly similar to wakefulness, but coordinated modulations of neuron responsiveness intermittently disconnect the local cortical networks from sensory ...
Allan Muller, Anton Filipchuk, Sophie Bagur, Brice Bathellier   +3 more
wiley   +1 more source

Exposure to Ketamine Anesthesia Affects Rat Impulsive Behaviour [PDF]

, 2016
Introduction: Ketamine is a general anesthetic (GA) that activates several neurotransmitter pathways in various part of the brain. The acute effects as GA are the most well-known and sought-after: to induce loss of responsiveness and to produce ...
Abildstrom, Acheson, António Melo, Bari, Barnes, Bedford, Bevins, Canet, Cardinal, Carli, Chambers, Clara Ferreira, Cottone, da Costa Araújo, Dalley, DeWilde, Duman, Evenden, Floresco, Frohlich, Glaser, Goto, Hancock, Hugo Leite-Almeida, José M. Pêgo, Kovalchuk, Krenk, Leite-Almeida, Li, Liu-Yesucevitz, Ma, Maeng, Masuzawa, Melo, Moller, Nelson, Nemeth, Nikiforuk, Nuno Sousa, Oliver, Paine, Pêgo, Riedel, Robinson, Sabino, Selnes, Shi, Smith, Steinmetz, Sun, Thomson, Vanderschuren, Yates   +52 more
core   +2 more sources

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration during isoflurane anaesthesia in Shetland ponies [PDF]

, 2017
Background The arterial pharmacokinetics of ketamine and norketamine enantiomers after racemic ketamine or S-ketamine i.v. administration were evaluated in seven gelding ponies in a crossover study (2-month interval). Methods Anaesthesia was induced with
Knobloch, M., Kronen, P. W., Landoni, M. F., Larenza, M. P., Levionnois, O. L., Schatzmann, U., Theurillat, R., Thormann, W.   +7 more
core  

Ketamine for the treatment of depression in patients receiving hospice care: a retrospective medical record review of thirty-one cases. [PDF]

, 2015
BACKGROUND: Depression is prevalent in patients receiving hospice care. Standard antidepressant medications do not work rapidly enough in this setting.
Fairman, Nathan, Hirst, Jeremy M., Iglewicz, Alana, Iglewicz, Boris, Irwin, Scott A., Morrison, Katherine, Nelesen, Richard A., Zhan, Tingting   +7 more
core   +2 more sources

Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Acute Pain Management From the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists

Regional anesthesia and pain medicine, 2018
Background Ketamine infusions have been used for decades to treat acute pain, but a recent surge in usage has made the infusions a mainstay of treatment in emergency departments, in the perioperative period in individuals with refractory pain, and in ...
E. Schwenk, E. Viscusi, A. Buvanendran, R. Hurley, A. Wasan, S. Narouze, A. Bhatia, Fred N. Davis, W. M. Hooten, Steven P. Cohen   +9 more
semanticscholar   +1 more source

Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity

Advanced Science, EarlyView.
A correlative imaging platform is developed to study how individual taste cells respond to different taste qualities. By linking cellular activity with molecular identity and environmental context, dual‐tuned taste cells capable of detecting both sweet and umami stimuli are identified.
Sungho Lee, Minjae Kim, Gha Yeon Park, Jubeen Yoon, Kunyoo Shin, Chang Ho Sohn, Myunghwan Choi   +6 more
wiley   +1 more source

A review on the recent application of ketamine in management of anesthesia, pain, and health care

Journal of Family Medicine and Primary Care, 2020
Ketamine is considered as a promising drug for many clinical applications even after five decades since its discovery. Ketamine is a dissociative anesthetic agent with a variety of pharmacological effects from anesthetic induction and maintenance to ...
Abolfazl Abdollahpour, Elham Saffarieh, Babak Hosseinzadeh Zoroufchi   +2 more
doaj   +1 more source

Double-Blind, Placebo-Controlled, Dose-Ranging Trial of Intravenous Ketamine as Adjunctive Therapy in Treatment-Resistant Depression (TRD)

Molecular Psychiatry, 2018
Numerous placebo-controlled studies have demonstrated the ability of ketamine, an NMDA receptor antagonist, to induce rapid (within hours), transient antidepressant effects when administered intravenously (IV) at subanesthetic doses (0.5 mg/kg over 40 ...
M. Fava, M. Freeman, M. Flynn, Heidi Judge, B. Hoeppner, C. Cusin, D. Ionescu, S. Mathew, Lee C Chang, D. Iosifescu, J. Murrough, C. Debattista, A. Schatzberg, M. Trivedi, M. Jha, G. Sanacora, S. Wilkinson, G. Papakostas   +17 more
semanticscholar   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source