Results 21 to 30 of about 114,264 (263)

Efficacy of combined subanesthetic ketamine infusion and cervical sympathetic blockade as a symptomatic treatment of PTSD/TBI in a special forces patient with a 1-year follow-up: A case report

Heliyon, 2023
Co-occurrence of posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) symptoms are particularly prevalent in the special operations forces' community, along with other related conditions (e.g., endocrine dysregulation, sleep disorders ...
Eugene Lipov, Zubin Sethi, Guriqbal Nandra, Christopher Frueh   +3 more
doaj  

Ketamine exacerbates cortical neuroapoptosis under hyperoxic conditions by upregulating expression of the N-methyl-D-aspartate receptor subunit NR1 in the developing rat brain

BMC Anesthesiology, 2018
Background Ketamine and hyperoxia are widely used in obstetric and pediatric settings. Either ketamine or hyperoxia has been reported to cause neuroapoptosis in the developing brain, and ketamine-induced neuronal apoptosis may involve a compensatory ...
Changyi Wu, Jun Wang, Xiangyang Guo, Ying Zhang   +3 more
doaj   +1 more source

Intravesical Instillation of Norketamine, a Ketamine Metabolite, and Induced Bladder Functional Changes in Rats

Toxics, 2021
This study aimed to determine the mechanism of ketamine-induced cystitis without metabolism. A total of 24 adult male Sprague-Dawley rats were separated into control, ketamine, and norketamine groups.
Chung-Hsin Yeh, Bo-He Chen, Xiao-Wen Tseng, Chun-Hou Liao, Wei-Kung Tsai, Han-Sun Chiang, Yi-No Wu   +6 more
doaj   +1 more source

'Special K' and a loss of cell-to-cell adhesion in proximal tubule-derived epithelial cells: modulation of the adherens junction complex by ketamine [PDF]

, 2013
Ketamine, a mild hallucinogenic class C drug, is the fastest growing ‘party drug’ used by 16–24 year olds in the UK. As the recreational use of Ketamine increases we are beginning to see the signs of major renal and bladder complications. To date however,
A Masszi, AA Eddy, AB Farris, AI Ivanov, AP Moreno, B Angres, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, CJ Morgan, Claire E. Hills, D Wood, Eleftherios Siamantouras, F Klingberg, G Remuzzi, Issac K-K Liu, K Sharma, Kieran P. Jefferson, M Maeda, M Wright, M Zeisberg, NM Selby, Paul E. Squires, PS Chu, R Kalluri, S Guo, Steen Henning Hansen, Tianrong Jin, Y Kanno   +33 more
core   +2 more sources

Efficacy of propofol versus ketamine in modified electroconvulsive therapy: A prospective randomized control trial

Journal of Acute Disease, 2022
Objective: To investigate the effects of propofol and ketamine on seizure duration, hemodynamics, and recovery of electroconvulsive therapy (ECT).
Debarshi Guha, Kiran Sheshadri, Shalendra Singh, Sonia Bhan   +3 more
doaj   +1 more source

Ketamine: NMDA receptors and beyond [PDF]

, 2016
Human studies examining the effects of the dissociative anesthetic ketamine as a model for psychosis and as a rapidly acting antidepressant have spurred great interest in understanding ketamine's actions at molecular, cellular, and network levels ...
Izumi, Yukitoshi, Mennerick, Steven, Zorumski, Charles F   +2 more
core   +2 more sources

The role of setting for ketamine abuse: clinical and preclinical evidence [PDF]

, 2012
Drug abuse is often seen as a unitary phenomenon, partly as a result of the discovery over the past three decades of shared mechanisms of action for addictive substances. Yet the pattern of drug taking is often very different from drug to drug.
Sprenger, Stewart, Tellier, Topp, Triffleman, Vollenweider, Vollenweider, Weir, White   +8 more
core   +1 more source

Repeated Administration of Ketamine can Induce Hippocampal Neurodegeneration and Long-Term Cognitive Impairment via the ROS/HIF-1α Pathway in Developing Rats

Cellular Physiology and Biochemistry, 2014
Background: Recent animal experiments have suggested that ketamine administration during development might induce widespread neurodegeneration and long-term cognitive deficits. The underlying mechanism is not fully understood.
Jia Yan, Yan Huang, Yi Lu, Jie Chen, Hong Jiang   +4 more
doaj   +1 more source

Considerations for physicians using ketamine for sedation of children in emergency departments [PDF]

Clinical and Experimental Emergency Medicine, 2017
Objective Ketamine use in emergency departments (EDs) for procedural sedation and analgesia is becoming increasingly common. However, few studies have examined patient factors related to adverse events associated with ketamine.
Woo Sung Kim, Ji Yeon Ku, Hanbyul Choi, Hyo Jeong Choi, Ho Jung Kim, Bora Lee   +5 more
doaj   +1 more source

Distinct cognitive and discriminative stimulus effects of ketamine enantiomers in rats [PDF]

, 2020
Although (S)-ketamine was approved for use in treatment-resistant depression in 2019, new preclinical findings suggest that (R)-ketamine might produce better efficacy and tolerability relative to (S)-ketamine. Here we evaluated the effects of (R)-, (S)-,
Golebiowska, Joanna, Hogendorf, Adam, Khoo, Shaun Yon-Seng, Kuziak, Agata, Matloka, Mikolaj, Moszczynski, Rafal, Nikiforuk, Agnieszka, Popik, Oskar, Popik, Piotr, Potasiewicz, Agnieszka, Witkin, Jeffrey M.   +10 more
core   +1 more source