Results 21 to 30 of about 345,134 (373)
NMDA Receptor Glycine Binding Site Modulators for Prevention and Treatment of Ketamine Use Disorder
Pharmaceuticals, 2023 Ketamine offers a fast-acting approach to relieving treatment-resistant depression, but its abuse potential is an issue of concern. As ketamine is a noncompetitive N-methyl-D-aspartate receptor (NMDAR) ion channel blocker, modulation of NMDAR might be an
Yu-Chin Hsiao +3 more
doaj +1 more source
Frontiers in Psychiatry, 2021 Ketamine is a glutamate N-methyl D-aspartate receptor antagonist and an anaesthetic agent that has been effectively used to treat depression. However, ketamine has also been increasingly used for recreational purposes.
Linying Liu +8 more
doaj +1 more source
Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability
Molecular Psychiatry, 2021 Ketamine, a racemic mixture of (S)-ketamine and (R)-ketamine enantiomers, has been used as an anesthetic, analgesic and more recently, as an antidepressant.
J. Bonaventura +13 more
semanticscholar +1 more source
American Journal of Psychiatry, 2022 OBJECTIVE Early evidence suggests that ketamine may be an effective treatment to sustain abstinence from alcohol. The authors investigated the safety and efficacy of ketamine compared with placebo in increasing abstinence in patients with alcohol use ...
M. Grabski +23 more
semanticscholar +1 more source
Remifentanil-ketamine vs. propofol-ketamine for sedation in pediatric patients undergoing colonoscopy: A randomized clinical trial [PDF]
Revista Brasileira de Anestesiologia, 2018 Background and objectives: Pediatric patients frequently require deep sedation or general anesthesia for colonoscopy. This study was designed to compare the sedative efficacy of remifentanil-ketamine combination with propofol-ketamine combination in ...
Feride Karacaer +7 more
doaj +3 more sources
British medical journal, 2022 Objective To confirm the rapid onset anti-suicidal benefits of ketamine in the short term and at six weeks, overall and according to diagnostic group. Design Prospective, double blind, superiority, randomised placebo controlled trial.
M. Abbar +11 more
semanticscholar +1 more source
Ketamine treatment for depression: a review
Discover Mental Health, 2022 This manuscript reviews the clinical evidence regarding single-dose intravenous (IV) administration of the novel glutamatergic modulator racemic (R,S)-ketamine (hereafter referred to as ketamine) as well as its S-enantiomer, intranasal esketamine, for ...
Mani Yavi +4 more
semanticscholar +1 more source
Sleep quality among individuals with ketamine use and the mediating role of craving
Scientific Reports, 2020 Sleep problems are common in Taiwan. Poor sleep may be associated with many illnesses, including substance use disorders. Ketamine use disorder has significantly increased in Taiwan in recent years and may lead to physical and cognitive problems. Craving
Cheng-Fang Yen +5 more
doaj +1 more source
JAMA psychiatry, 2022 Importance Whether ketamine is as effective as electroconvulsive therapy (ECT) among patients with major depressive episode remains unknown. Objective To systematically review and meta-analyze data about clinical efficacy and safety for ketamine and ...
T. Rhee +8 more
semanticscholar +1 more source
Anaesthesia and Intensive Care, 2002 Ketamine hydrochloride is a safe and rapid-acting non-opioid, lipid soluble anaesthetic with a short elimination half-life that is used for medical and veterinary purposes. It produces a state of “dissociative anaesthesia”, probably from action on N-methyl-D-aspartate (NMDA) receptors.
H R, Pal, N, Berry, R, Kumar, R, Ray
openaire +2 more sources