Results 21 to 30 of about 235,967 (343)
JAMA psychiatry, 2022 Importance Whether ketamine is as effective as electroconvulsive therapy (ECT) among patients with major depressive episode remains unknown. Objective To systematically review and meta-analyze data about clinical efficacy and safety for ketamine and ...
T. Rhee +8 more
semanticscholar +1 more source
Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability
Molecular Psychiatry, 2021 Ketamine, a racemic mixture of (S)-ketamine and (R)-ketamine enantiomers, has been used as an anesthetic, analgesic and more recently, as an antidepressant.
J. Bonaventura +13 more
semanticscholar +1 more source
Sleep quality among individuals with ketamine use and the mediating role of craving
Scientific Reports, 2020 Sleep problems are common in Taiwan. Poor sleep may be associated with many illnesses, including substance use disorders. Ketamine use disorder has significantly increased in Taiwan in recent years and may lead to physical and cognitive problems. Craving
Cheng-Fang Yen +5 more
doaj +1 more source
F1000Research, 2017 The efficacy of theN-methyl-D-aspartate receptor antagonist ketamine as an analgesic agent is still under debate, especially for indications such as chronic pain. To understand the efficacy of ketamine for relief of pain, we performed a literature search for relevant narrative and systematic reviews and meta-analyses.
Kelly Jonkman +5 more
openaire +3 more sources
Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine
Molecular Psychiatry, 2021 (R,S)-ketamine elicits rapid-acting and sustained antidepressant actions in treatment-resistant patients with depression. (R)-ketamine produces longer-lasting antidepressant effects than (S)-ketamine in rodents; however, the precise molecular mechanisms ...
W. Yao +8 more
semanticscholar +1 more source
Ketamine infusion as a sedative-analgesic in severe ARDS (KISS)
Journal of Community Hospital Internal Medicine Perspectives, 2021 Rationale Ketamine has been used as a sedative analgesic in trauma setting, but data regarding its efficacy and safety is lacking in severe ARDS.
Ramakanth Pata +11 more
doaj +1 more source
Frontiers in Neuroscience, 2021 Ketamine has been in use for over 50 years as a general anesthetic, acting primarily through blockade of N-methyl-D-aspartate receptors in the brain. Recent studies have demonstrated that ketamine also acts as a potent and rapid-acting antidepressant ...
Zachary Geiger +6 more
doaj +1 more source
Frontiers in Psychiatry, 2022 Ketamine has gained rapid popularity as a treatment option for treatment resistant depression (TRD). Though seen only in limited contexts, ketamine is a potential drug of abuse, addiction and diversion.
Brittany Chubbs +6 more
doaj +1 more source
BJPsych Open, 2021 Background In the past two decades, subanaesthetic doses of ketamine have been demonstrated to have rapid and sustained antidepressant effects, and accumulating research has demonstrated ketamine's therapeutic effects for a range of psychiatric ...
Z. Walsh +7 more
semanticscholar +1 more source
Activation of σ1-Receptors by R-Ketamine May Enhance the Antidepressant Effect of S-Ketamine
Biomedicines, 2023 Ketamine is a racemic mixture composed of two enantiomers, S-ketamine and R-ketamine. In preclinical studies, both enantiomers have exhibited antidepressant effects, but these effects are attributed to distinct pharmacological activities.
Hans O. Kalkman
doaj +1 more source