Results 31 to 40 of about 196,719 (315)

Ketamine exacerbates cortical neuroapoptosis under hyperoxic conditions by upregulating expression of the N-methyl-D-aspartate receptor subunit NR1 in the developing rat brain

BMC Anesthesiology, 2018
Background Ketamine and hyperoxia are widely used in obstetric and pediatric settings. Either ketamine or hyperoxia has been reported to cause neuroapoptosis in the developing brain, and ketamine-induced neuronal apoptosis may involve a compensatory ...
Changyi Wu, Jun Wang, Xiangyang Guo, Ying Zhang   +3 more
doaj   +1 more source

Activation of σ1-Receptors by R-Ketamine May Enhance the Antidepressant Effect of S-Ketamine

Biomedicines, 2023
Ketamine is a racemic mixture composed of two enantiomers, S-ketamine and R-ketamine. In preclinical studies, both enantiomers have exhibited antidepressant effects, but these effects are attributed to distinct pharmacological activities.
Hans O. Kalkman
doaj   +1 more source

Ketamine and depression [PDF]

British Journal of Anaesthesia, 2018
The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above. ; Since Domino and colleagues reported the first clinical use of ketamine more than half a century ago there have been many clinical
Hirota, K, Lambert, DG
openaire   +3 more sources

Enantioselective capillary electrophoresis : fundamental aspects and application to the "in vitro" assessment of CYP3A4 mediated ketamine N-demethylation [PDF]

, 2012
A large number of pharmaceutical substances are administered as racemates, consisting of two enantiomers with typically different pharmacodynamic and pharmacokinetic profiles.
Kwan, Hiu Ying
core   +1 more source

Repeated Administration of Ketamine can Induce Hippocampal Neurodegeneration and Long-Term Cognitive Impairment via the ROS/HIF-1α Pathway in Developing Rats

Cellular Physiology and Biochemistry, 2014
Background: Recent animal experiments have suggested that ketamine administration during development might induce widespread neurodegeneration and long-term cognitive deficits. The underlying mechanism is not fully understood.
Jia Yan, Yan Huang, Yi Lu, Jie Chen, Hong Jiang   +4 more
doaj   +1 more source

Safety and feasibility of continuous ketamine infusion for analgosedation in medical and cardiac ICU patients who received mechanical ventilation support: A retrospective cohort study.

PLoS ONE, 2022
PurposeTo assess the effect of continuous ketamine administration in patients admitted to medical and cardiac intensive care units (ICUs) and received mechanical ventilation support.MethodsWe conducted a retrospective cohort study between March 2012 and ...
Hohyung Jung, Jihye Lee, Hyun Young Ahn, Jeong Hoon Yang, Gee Young Suh, Ryoung-Eun Ko, Chi Ryang Chung   +6 more
doaj   +1 more source

Safety, effectiveness and tolerability of sublingual ketamine in depression and anxiety: A retrospective study of off-label, at-home use

Frontiers in Psychiatry, 2022
Intravenous and intranasal ketamine have been shown to be effective therapeutic options in patients suffering from treatment-resistant depression (TRD).
Kazi Hassan, William M. Struthers, Aditya Sankarabhotla, Patrick Davis   +3 more
doaj   +1 more source

A comparison of medetomidine and its active enantiomer dexmedetomidine when administered with ketamine in mice [PDF]

, 2013
Medetomidine-ketamine (MK) and dexmedetomidine-ketamine (DK) are widely used to provide general anaesthesia in laboratory animals, but have not been compared directly in many of these species, including rodents.
Burnside, Wesley M., Thomas, A.A., Cameron, A.I., Flecknell, Paul A., Burnside, Wesley, Burnside, W.M., Thomas, Aurélie A, Cameron, Angus I, Flecknell, P.A., Cameron, Angus, Flecknell, Paul, Thomas, Aurélie   +11 more
core   +1 more source

Efficacy of propofol versus ketamine in modified electroconvulsive therapy: A prospective randomized control trial

Journal of Acute Disease, 2022
Objective: To investigate the effects of propofol and ketamine on seizure duration, hemodynamics, and recovery of electroconvulsive therapy (ECT).
Debarshi Guha, Kiran Sheshadri, Shalendra Singh, Sonia Bhan   +3 more
doaj   +1 more source

Safety and tolerability of intramuscular and sublingual ketamine for psychiatric treatment in the Roots To Thrive ketamine-assisted therapy program: A retrospective chart review

, 2023
This study reports on adverse effects of intramuscular and sublingual ketamine dosing in a community group psychotherapy setting among 128 participants across four cohorts.https://viurrspace.ca/bitstream/handle/10613/27451/Dames2023.pdf?sequence=
Tsang, Vivian W.L., Dames, Shannon, Walsh, Zach, Kryskow, Pamela, Tao, Brendan   +4 more
core   +1 more source