Results 71 to 80 of about 235,967 (343)

Effects of subanesthetic intravenous ketamine infusion on neuroplasticity-related proteins in male and female Sprague-Dawley rats

IBRO Neuroscience Reports, 2021
Although ketamine, a multimodal dissociative anesthetic, is frequently used for analgesia and treatment-resistant major depression, molecular mechanisms of ketamine remain unclear.
Michael Zhang, Haley F. Spencer, Rina Y. Berman, Kennett D. Radford, Kwang H. Choi   +4 more
doaj   +1 more source

Double-Blind, Placebo-Controlled, Dose-Ranging Trial of Intravenous Ketamine as Adjunctive Therapy in Treatment-Resistant Depression (TRD)

Molecular Psychiatry, 2018
Numerous placebo-controlled studies have demonstrated the ability of ketamine, an NMDA receptor antagonist, to induce rapid (within hours), transient antidepressant effects when administered intravenously (IV) at subanesthetic doses (0.5 mg/kg over 40 ...
M. Fava, M. Freeman, M. Flynn, Heidi Judge, B. Hoeppner, C. Cusin, D. Ionescu, S. Mathew, Lee C Chang, D. Iosifescu, J. Murrough, C. Debattista, A. Schatzberg, M. Trivedi, M. Jha, G. Sanacora, S. Wilkinson, G. Papakostas   +17 more
semanticscholar   +1 more source

Functionalized Reduced Graphene Oxide‐Based Nanocomposite Hydrogels for Enhanced Osteogenesis in Bone Tissue Engineering

Advanced Healthcare Materials, EarlyView.
Charge‐opposed reduced graphene oxide fillers are co‐integrated into biopolymeric nanocomposite scaffolds, synergistically enhance osteogenesis. Multiscale characterization reveals how surface chemistry and porosity dictate ectopic mineral architecture.
George Mihail Vlăsceanu, Cătălina Ionela Zamfir, Cornel Baltă, Hildegard Herman, Alina Ciceu, Maria Alexandra Duma, Mariana Ioniță, Roxana‐Cristina Popescu, Anca Hermenean   +8 more
wiley   +1 more source

Ketamine Use for Cancer and Chronic Pain Management

Frontiers in Pharmacology, 2021
Ketamine, an N-methyl-D-aspartate receptor antagonist, is widely known as a dissociative anesthetic and phencyclidine derivative. Due to an undesirable adverse event profile when used as an anesthetic it had widely fallen out of human use in favor of ...
C. Culp, H. Kim, S. Abdi
semanticscholar   +1 more source

Co‐Delivery of Ca‐MOF and Mg‐MOF Using Nanoengineered Hydrogels to Promote In Situ Mineralization and Bone Defect Repair: In Vitro and In Vivo Analysis

Advanced Healthcare Materials, EarlyView.
Metal‐organic frameworks (MOFs) have been synthesized using calcium (Ca‐MOF), magnesium (Mg‐MOF), and as hybrids (Ca/Mg‐MOF) for bone healing applications. MOFs are integrated into hydrogel polymer networks for injectable, sprayable, and coating applications.
Cho‐E Choi, Chao Liang, Yasmeen Shamiya, Sang Jin Lee, Arghya Paul   +4 more
wiley   +1 more source

Ketamine Modulates Zic5 Expression via the Notch Signaling Pathway in Neural Crest Induction

Frontiers in Molecular Neuroscience, 2018
Ketamine is a potent dissociative anesthetic and the most commonly used illicit drug. Many addicts are women at childbearing age. Although ketamine has been extensively studied as a clinical anesthetic, its effects on embryonic development are poorly ...
Yu Shi, Yu Shi, Jiejing Li, Chunjiang Chen, Yongwu Xia, Yongwu Xia, Yanxi Li, Pan Zhang, Pan Zhang, Ying Xu, Tingyu Li, Weihui Zhou, Weihong Song, Weihong Song   +13 more
doaj   +1 more source

S-ketamine and intranasal application: alternatives for the castration of male suckling piglets?

BMC Veterinary Research, 2021
Background The intramuscular injection of ketamine and azaperone was proposed as a suitable anaesthesia for male suckling piglets for surgical castration.
Sabrina Becker, Anna Maier, Saskia Peters, Kathrin Büttner, Gerald Reiner   +4 more
doaj   +1 more source

Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Acute Pain Management From the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists

Regional anesthesia and pain medicine, 2018
Background Ketamine infusions have been used for decades to treat acute pain, but a recent surge in usage has made the infusions a mainstay of treatment in emergency departments, in the perioperative period in individuals with refractory pain, and in ...
E. Schwenk, E. Viscusi, A. Buvanendran, R. Hurley, A. Wasan, S. Narouze, A. Bhatia, Fred N. Davis, W. M. Hooten, Steven P. Cohen   +9 more
semanticscholar   +1 more source

Association of Ketamine With Psychiatric Symptoms and Implications for Its Therapeutic Use and for Understanding Schizophrenia

JAMA Network Open, 2020
This meta-analysis assesses the psychopathological outcomes in healthy volunteers and patients with schizophrenia treated with ketamine and the experimental factors associated with these findings.
K. Beck, Guy Hindley, F. Borgan, Cedric E. Ginestet, R. McCutcheon, S. Brugger, N. Driesen, M. Ranganathan, D. D’Souza, M. Taylor, J. Krystal, O. Howes   +11 more
semanticscholar   +1 more source

Tunicate‐Inspired Carboxymethyl Cellulose Hydrogel Filler for Treating Age‐Associated Vocal Fold Atrophy

Advanced Healthcare Materials, EarlyView.
The pyrogallol‐conjugated carboxymethylcellulose (CMC‐PG) hydrogel is applicated as a filler for the treatment of presbylaryngis, a vocal fold atrophy. CMC‐PG provides a bulking effect to the vocal folds. CMC‐PG is readily injectable and tissue adhesive, enabling sustained release of growth factor over long period.
Jihoon Jeon, Sang‐Yoon Han, Ji Suk Choi, Soojeong Choi, Dongkyun Shin, Mikyung Shin, Seong Keun Kwon, Seung‐Woo Cho   +7 more
wiley   +1 more source