Results 121 to 130 of about 57,314 (316)
A Randomized Comparative Clinical Trial of Terbinafin 1% Cream and Ketoconazole 2% Cream in the Treatment of Pityriasis Versicolor [PDF]
, 1969 Fardin Gharibi +3 more
openalex +1 more source
Effects of Ketoconazole on the Pharmacokinetics of Lenvatinib (E7080) in Healthy Participants
Clinical pharmacology in drug development, 2014 Lenvatinib is an oral, multitargeted, tyrosine kinase inhibitor under clinical investigation in solid tumors. In vitro evidence indicates that lenvatinib metabolism may be modulated by ketoconazole, an inhibitor of CYP3A4 and p‐glycoprotein.
R. Shumaker +5 more
semanticscholar +1 more source
Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone [PDF]
, 2018 Purpose: The main metabolic pathways of oxycodone, a potent opioid analgetic, are N-demethylation (CYP3A4) to inactive noroxycodone and O-demethylation (CYP2D6) to active oxymorphone.
Drewe, Jürgen +5 more
core
Clinical Pharmacology in Drug Development, Volume 14, Issue 8, Page 605-613, August 2025.Abstract Cytochrome P450 (CYP) 3A plays a significant role in fruquintinib metabolism in vitro. This 2‐part, 2‐period fixed‐sequence study investigated the impact of CYP3A inhibition (itraconazole) and CYP3A induction (rifampin) on the pharmacokinetics (PK) of fruquintinib and M11, its main metabolite.
Martha Gonzalez +5 more
wiley +1 more source
Thermal, spectroscopic, and dissolution studies of ketoconazole–Pluronic F127 system
Journal of Thermal Analysis and Calorimetry, 2014 One strategy for improving the dissolution of poorly water soluble drugs is to prepare solid dispersions such as binary mixtures with hydrophilic carriers.
B. Karolewicz +5 more
semanticscholar +1 more source
Long-term low-dose ketoconazole treatment in bilateral macronodular adrenal hyperplasia [PDF]
, 2014 Medical therapy for Cushing's syndrome due to bilateral macronodular adrenal hyperplasia (BMAH) is generally administered for a limited time before surgery.
Comte-Perret, S., Gomez, F., Zanchi, A.
core +1 more source
Clinical Pharmacology &Therapeutics, Volume 118, Issue 2, Page 489-496, August 2025.Pazopanib is an oral tyrosine kinase inhibitor used in patients with either metastatic renal cell carcinoma or soft tissue sarcoma. Pazopanib has a high interindividual variability in pharmacokinetics and pharmacodynamics and a well‐established exposure–response relationship. Therefore, therapeutic drug monitoring is recommended to improve the efficacy–
Amy Rieborn +6 more
wiley +1 more source
PLoS ONE, 2017 Leishmaniasis is a group of diseases caused by protozoa of Leishmania genus. The currently available treatments for this disease are expensive, present high toxicity and are associated to difficulties of healing and parasite resistance.
Débora Cristina de Oliveira Nunes +7 more
doaj +1 more source
Pharmacokinetics of ketoconazole and treatment evaluation in candidal infections. [PDF]
, 1984 M Bardare +3 more
openalex +1 more source