Results 41 to 50 of about 42,303 (288)
The Ketogenic Diet: An Answer for Autism? [PDF]
, 2019 Lacking substantial evidence regarding its genetic identity, autism spectrum disorder (ASD) is a remarkably misunderstood condition with limited options for effective treatment.
Perez, Anne
core +1 more source
Starvation of Cancer via Induced Ketogenesis and Severe Hypoglycemia
, 2014 Neoplasms are highly dependent on glucose as their substrate for energy production and are generally not able to catabolize other fuel sources such as ketones and fatty acids.
Kapelner, Adam, Vorsanger, Matthew
core +1 more source
Paroxysmal eye–head movements in Glut1 deficiency syndrome [PDF]
, 2017 Objective:To describe a characteristic paroxysmal eye–head movement disorder that occurs in infants with Glut1 deficiency syndrome (Glut1 DS).Methods:We retrospectively reviewed the medical charts of 101 patients with Glut1 DS to obtain clinical data ...
De Vivo, Darryl C +5 more
core +2 more sources
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
Validation of an Italian Questionnaire of Adherence to the Ketogenic Dietary Therapies: iKetoCheck
Foods, 2023 Ketogenic dietary therapies (KDTs) are an effective and safe non-pharmacological treatment for drug-resistant epilepsy, but adherence can be challenging for both patients and caregivers.
Lenycia de Cassya Lopes Neri +10 more
doaj +1 more source
Effect of oxidative stress on ABC transporters: contribution to epilepsy pharmacoresistance [PDF]
, 2017 Epilepsy is a neurological disorder affecting around 1%-2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression
Grewal, G. K. +5 more
core +2 more sources
Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang +10 more
wiley +1 more source
Dr. Sulaiman Al Habib Medical JournalMelanocortin-4 receptor (MC4R) mutations disrupt body weight homeostasis and the appetite-feedback loop, affecting approximately 1%–6% of the population.
Bushra Hafez +2 more
doaj +1 more source
Adenosine and Ketogenic Treatments
Journal of Caffeine and Adenosine Research, 2020 It is well known that the neuromodulator adenosine, acting through the adenosine A1 receptor subtype, can limit or stop seizures. In 2008, adenosine was proposed as a key component of the anticonvulsant mechanism of the ketogenic diet (KD), a very low carbohydrate diet that can be highly effective in drug-refractory epilepsy.
David N, Ruskin +2 more
openaire +3 more sources
Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. [PDF]
, 2017 Glutamate is the dominant excitatory neurotransmitter in the brain, but under conditions of metabolic stress it can accumulate to excitotoxic levels.
Andreyev, Alexander Y +12 more
core +1 more source