Results 91 to 100 of about 25,226 (299)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Assessment of the Efficacy of Adhering to the Ketogenic Diet on Adipokines (Betatrophin, Endotrophin, and Meteorin-Like Protein) in Obese Women with Polycystic Ovary Syndrome

Iraqi Journal of Pharmaceutical Sciences
Obesity increases the detrimental effects on both reproductive and metabolic indicators of polycystic ovarian syndrome (PCOS). The ketogenic diet affects the outcomes of reproductive and metabolic characteristics in PCOS women.
Nazar Sattar Harbi, Waleed N. Al-Darkazali, Waeel M. Hamud   +2 more
doaj   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Efficacy of the Ketogenic Diet in Children with Refractory Epilepsy

, 2021
The purpose of this paper is to describe the effectiveness of the ketogenic diet (KD) in reducing or eliminating seizures in children with refractory epilepsy.
Kozlowski, Killian;
core  

The Ketogenic Diet

, 2022
This paper explores a total of six research studies and will contain a literature review and proposal for further study regarding the effectiveness of the ketogenic diet as an adjuvant cancer therapy. Each study addresses a variety of different factors involved in KD implementation, ranging from effects on body composition and lipid profiles, to self ...
openaire   +3 more sources

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Ketogenic diet for schizophrenia: clinical implication

, 2019
Purpose of review: The aim of this article is to review recent findings on the efficacy of ketogenic diet in preclinical models and in patients with schizophrenia.
Sarnyai, Zoltan, Kraeuter, Ann-Katrin, Palmer, Christopher   +2 more
core   +1 more source

Ketogenic diet and astrocyte/neuron metabolic interactions

, 2007
The ketogenic diet is an anticonvulsant diet enriched in fat. It provides the body with a minimal protein requirement and a restricted carbohydrate supply, the vast majority of calories (more than 80-90%) being given by fat.
Bac Pierre, Delplanque Bernadette, Vamecq Joseph, Maurois Pierre, Pages Nicole   +4 more
core   +2 more sources

Real‐world‐data for phenotypes and genotypes of rare monogenic genetic epilepsies and genes of uncertain significance for epilepsy

Epilepsia Open, EarlyView.
Abstract Objectives The objectives of this study were to develop a real‐world‐data (RWD) database for patients with epilepsy to provide further real‐world‐evidence (RWE) for monogenic genetic epilepsies; to assess the usefulness of a diagnostic algorithm in epilepsy; and to examine protein 3D structures using in silico tools to predict variant ...
Haley Morris, Elizabeth Mathew, Shalini Bahl, Marta Villa‐Lopez, Saadet Mercimek‐Andrews   +4 more
wiley   +1 more source