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The ketogenic diet and epilepsy
Current Opinion in Clinical Nutrition and Metabolic Care, 2008The ketogenic diet has long been used to treat medically refractory epilepsy. The mechanisms underlying its clinical effects, however, have remained a mystery. The evidence to date suggests that a fundamental shift from glycolysis to intermediary metabolism induced by the ketogenic diet is necessary and sufficient for clinical efficacy.
Do Young, Kim, Jong M, Rho
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2003
The ketogenic diet is a diet high in fat but low in carbohydrate and it is suggested that this diet reduces seizure frequency. Currently, this diet is used mainly for children who continue to have seizures despite treatment with antiepileptic drugs.To overview the evidence from randomized controlled trials regarding the effects of ketogenic diets.We ...
R, Levy, P, Cooper
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The ketogenic diet is a diet high in fat but low in carbohydrate and it is suggested that this diet reduces seizure frequency. Currently, this diet is used mainly for children who continue to have seizures despite treatment with antiepileptic drugs.To overview the evidence from randomized controlled trials regarding the effects of ketogenic diets.We ...
R, Levy, P, Cooper
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Advances in Pediatrics, 1997
There has been a dramatic resurgence of interest in the ketogenic diet during the past several years. For many children with difficult-to-control epilepsy, the diet presents an alternative approach to trying multiple medications. The ketogenic diet's current success rate, when properly executed, greatly exceeds that of the medications which have ...
T D, Swink, E P, Vining, J M, Freeman
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There has been a dramatic resurgence of interest in the ketogenic diet during the past several years. For many children with difficult-to-control epilepsy, the diet presents an alternative approach to trying multiple medications. The ketogenic diet's current success rate, when properly executed, greatly exceeds that of the medications which have ...
T D, Swink, E P, Vining, J M, Freeman
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Ketogenic Diets in the Treatment of Epilepsy
Current Pharmaceutical Design, 2018Although a larger number of antiepileptic drugs became available in the last decades, epilepsy remains drug-resistant in approximately a third of patients. Ketogenic diet (KD), first proposed at the beginning of the last century, is complex and has anticonvulsant effects, yet not completely understood.
Elia, Maurizio +3 more
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1999
This paper represents the opinion of the Central Nervous System Practice and Research Network (PRN) of the American College of Clinical Pharmacy. It does not necessarily represent an official ACCP commentary, guideline, or statement of policy or position.
Jacquelyn L. Bainbridge +2 more
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This paper represents the opinion of the Central Nervous System Practice and Research Network (PRN) of the American College of Clinical Pharmacy. It does not necessarily represent an official ACCP commentary, guideline, or statement of policy or position.
Jacquelyn L. Bainbridge +2 more
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2016
AbstractAs the classical ketogenic diet fast approaches a centennial anniversary, the wider ketogenic landscape has expanded considerably both in application and implementation. Although still extensively used today, this traditional dietary therapy has been the basis for development of alternative ketogenic protocols.
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AbstractAs the classical ketogenic diet fast approaches a centennial anniversary, the wider ketogenic landscape has expanded considerably both in application and implementation. Although still extensively used today, this traditional dietary therapy has been the basis for development of alternative ketogenic protocols.
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2004
The energy requirements of the human brain are enormous. Cerebral oxygen consumption is 35 mL/min/kg or approx 50 mL/min in the adult brain. The rate of wholebody O2 consumption is 250 mL/min, indicating that approx 20% of oxygen utilization is directed toward the needs of the brain, which occupies only 2% of body weight.
Eric H. Kossoff, John M. Freeman
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The energy requirements of the human brain are enormous. Cerebral oxygen consumption is 35 mL/min/kg or approx 50 mL/min in the adult brain. The rate of wholebody O2 consumption is 250 mL/min, indicating that approx 20% of oxygen utilization is directed toward the needs of the brain, which occupies only 2% of body weight.
Eric H. Kossoff, John M. Freeman
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Neurology, 2000
In 1928, W. G. Lennox stated, referring to the ketogenic diet, “One who is confronted with the task of controlling seizures in a person with epilepsy grasps at any straw.”1 Even today, we must often grasp at straws when treating patients with refractory epilepsy. The ketogenic diet has had a checkered history.
Carl E. Stafstrom, Susan Spencer
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In 1928, W. G. Lennox stated, referring to the ketogenic diet, “One who is confronted with the task of controlling seizures in a person with epilepsy grasps at any straw.”1 Even today, we must often grasp at straws when treating patients with refractory epilepsy. The ketogenic diet has had a checkered history.
Carl E. Stafstrom, Susan Spencer
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Journal of the American Dietetic Association, 1997
The ketogenic diet is a high-fat diet that maintains the body's starvation mechanism, with exogenous fat provided for metabolism in lieu of stored fat. Mild dehydration is important to prevent dilution of the level of ketones in circulation at any given time.
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The ketogenic diet is a high-fat diet that maintains the body's starvation mechanism, with exogenous fat provided for metabolism in lieu of stored fat. Mild dehydration is important to prevent dilution of the level of ketones in circulation at any given time.
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JAMA: The Journal of the American Medical Association, 1928
The ketogenic diet was introduced in 19241after two years of clinical trial. Wilder,2in 1921, on the basis of Geyelin's3results with starvation, suggested that diets in which the proportion of carbohydrate and protein was sufficiently restricted might offer a method of treatment of epilepsy. It was on the basis of Wilder's suggestion that the high fat,
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The ketogenic diet was introduced in 19241after two years of clinical trial. Wilder,2in 1921, on the basis of Geyelin's3results with starvation, suggested that diets in which the proportion of carbohydrate and protein was sufficiently restricted might offer a method of treatment of epilepsy. It was on the basis of Wilder's suggestion that the high fat,
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