Results 11 to 20 of about 22,770 (160)

The Role of the Rare Variants in the Genes Encoding the Alpha-Ketoglutarate Dehydrogenase in Alzheimer’s Disease

Life, 2021
There is increasing evidence that several mitochondrial abnormalities are present in the brains of patients with Alzheimer’s disease (AD). Decreased alpha-ketoglutarate dehydrogenase complex (αKGDHc) activity was identified in some patients with AD.
Dora Csaban, Klara Pentelenyi, Renata Toth-Bencsik, Anett Illes, Zoltan Grosz, Andras Gezsi, Maria Judit Molnar   +6 more
doaj   +1 more source

The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis

RNA Biology, 2023
The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations of metabolic enzymes which affect the integrity of TCA cycle are implicated ...
Tao Shen, Haiyang Wang, Bin Tang, Guoping Zhu, Xiangting Wang   +4 more
doaj   +1 more source

Dietary α-ketoglutarate alleviates glycinin and β-conglycinin induced damage in the intestine of mirror carp (Cyprinus carpio)

Frontiers in Immunology, 2023
This study investigated the glycinin and β-conglycinin induced intestinal damage and α-ketoglutarate alleviating the damage of glycinin and β-conglycinin in intestine.
Qiaohua Luo, Qiaohua Luo, Rendong Qian, Rendong Qian, Zongsheng Qiu, Zongsheng Qiu, Fernando Y. Yamamoto, Fernando Y. Yamamoto, Yingying Du, Yingying Du, Xiaowen Lin, Xiaowen Lin, Jianhua Zhao, Jianhua Zhao, Qiyou Xu, Qiyou Xu   +15 more
doaj   +1 more source

Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species [PDF]

The Journal of Neuroscience, 2004
Mitochondria-produced reactive oxygen species (ROS) are thought to contribute to cell death caused by a multitude of pathological conditions. The molecular sites of mitochondrial ROS production are not well established but are generally thought to be located in complex I and complex III of the electron transport chain.
Starkov, Anatoly A., Fiskum, G., Chinopoulos, Christos, Lorenzo, BJ., Browne, SE., Patel, Mulchand S., Beal, M. Flint   +6 more
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Zn2+ Inhibits α-Ketoglutarate-stimulated Mitochondrial Respiration and the Isolated α-Ketoglutarate Dehydrogenase Complex [PDF]

Journal of Biological Chemistry, 2000
Intracellular free Zn(2+) is elevated in a variety of pathological conditions, including ischemia-reperfusion injury and Alzheimer's disease. Impairment of mitochondrial respiration is also associated with these pathological conditions. To test whether elevated Zn(2+) and impaired respiration might be linked, respiration of isolated rat liver ...
A M, Brown, B S, Kristal, M S, Effron, A I, Shestopalov, P A, Ullucci, K F, Sheu, J P, Blass, A J, Cooper   +7 more
openaire   +2 more sources

αKG-driven RNA polymerase II transcription of cyclin D1 licenses malic enzyme 2 to promote cell-cycle progression

Cell Reports, 2023
Summary: Increased metabolic activity usually provides energy and nutrients for biomass synthesis and is indispensable for the progression of the cell cycle.
Yanting Yang, Zhenxi Zhang, Wei Li, Yufan Si, Li Li, Wenjing Du   +5 more
doaj   +1 more source

Genetics of the alpha-ketoglutarate dehydrogenase complex of Bacillus subtilis [PDF]

Journal of Bacteriology, 1978
The enzymatic defects in a number of Bacillus subtilis mutants of the alpha-ketoglutarate dehydrogenase complex lacking activity have been investigated. Mutants in the citK locus, as well as a series of deletions of unknown length covering the citK locus, are deficient in E1 of the complex, alpha-ketoglutarate dehydrogenase, but have normal activities ...
J A, Hoch, H J, Coukoulis
openaire   +2 more sources

Structural analysis of an endogenous 4-megadalton succinyl-CoA-generating metabolon

Communications Biology, 2023
The oxoglutarate dehydrogenase complex (OGDHc) participates in the tricarboxylic acid cycle and, in a multi-step reaction, decarboxylates α-ketoglutarate, transfers succinyl to CoA, and reduces NAD+. Due to its pivotal role in metabolism, OGDHc enzymatic
Ioannis Skalidis, Fotis L. Kyrilis, Christian Tüting, Farzad Hamdi, Toni K. Träger, Jaydeep Belapure, Gerd Hause, Marta Fratini, Francis J. O’Reilly, Ingo Heilmann, Juri Rappsilber, Panagiotis L. Kastritis   +11 more
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A reversible state of hypometabolism in a human cellular model of sporadic Parkinson’s disease

Nature Communications, 2023
Sporadic Parkinson’s Disease (sPD) is a progressive neurodegenerative disorder caused by multiple genetic and environmental factors. Mitochondrial dysfunction is one contributing factor, but its role at different stages of disease progression is not ...
Sebastian Schmidt, Constantin Stautner, Duc Tung Vu, Alexander Heinz, Martin Regensburger, Ozge Karayel, Dietrich Trümbach, Anna Artati, Sabine Kaltenhäuser, Mohamed Zakaria Nassef, Sina Hembach, Letyfee Steinert, Beate Winner, Winkler Jürgen, Martin Jastroch, Malte D. Luecken, Fabian J. Theis, Gil Gregor Westmeyer, Jerzy Adamski, Matthias Mann, Karsten Hiller, Florian Giesert, Daniela M. Vogt Weisenhorn, Wolfgang Wurst   +23 more
doaj   +1 more source

In vivo assembly of yeast mitochondrial alpha-ketoglutarate dehydrogenase complex. [PDF]

Molecular and Cellular Biology, 1991
The assembly of alpha-ketoglutarate dehydrogenase complex (KGDC) has been studied in wild-type Saccharomyces cerevisiae and in respiratory-deficient strains (pet) with mutations in KGD1 and KGD2, the structural genes for alpha-ketoglutarate dehydrogenase (KE1) and dihydrolipoyl transsuccinylase (KE2) components, respectively.
B, Repetto, A, Tzagoloff
openaire   +2 more sources