Results 31 to 40 of about 22,770 (160)

Kinetic Advantages of Hetero-Enzyme Complexes with Glutamate Dehydrogenase and the α-Ketoglutarate Dehydrogenase Complex

Journal of Biological Chemistry, 1989
We have found previously (Fahien, L.A., Kmiotek, E.H., MacDonald, M. J., Fibich, B., and Mandic, M. (1988) J. Biol. Chem. 263, 10687-10697) that glutamate-malate oxidation can be enhanced by cooperative binding of mitochondrial aspartate aminotransferase and malate dehydrogenase to the alpha-ketoglutarate dehydrogenase complex.
L A, Fahien, M J, MacDonald, J K, Teller, B, Fibich, C M, Fahien   +4 more
openaire   +2 more sources

Complex Mitochondrial Dysfunction Induced by TPP⁺-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells

Cells, 2020
The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy.
Sebastián Fuentes-Retamal, Cristian Sandoval-Acuña, Liliana Peredo-Silva, Daniela Guzmán-Rivera, Mario Pavani, Natalia Torrealba, Jaroslav Truksa, Vicente Castro-Castillo, Mabel Catalán, Ulrike Kemmerling, Félix A. Urra, Jorge Ferreira   +11 more
doaj   +1 more source

Is impaired energy production a novel insight into the pathogenesis of pyridoxine-dependent epilepsy due to biallelic variants in ALDH7A1?

PLoS ONE, 2021
BackgroundPyridoxine-dependent epilepsy (PDE) is due to biallelic variants in ALDH7A1 (PDE-ALDH7A1). ALDH7A1 encodes α-aminoadipic semialdehyde dehydrogenase in lysine catabolism.
Anastasia Minenkova, Erwin E W Jansen, Jessie Cameron, Rob Barto, Thomas Hurd, Lauren MacNeil, Gajja S Salomons, Saadet Mercimek-Andrews   +7 more
doaj   +1 more source

Succinate dehydrogenase inversely regulates red cell distribution width and healthy life span in chronically hypoxic mice

JCI Insight, 2022
Increased red cell distribution width (RDW), which measures erythrocyte mean corpuscular volume (MCV) variability (anisocytosis), has been linked to early mortality in many diseases and in older adults through unknown mechanisms.
Bora E. Baysal, Abdulrahman A. Alahmari, Tori C. Rodrick, Debra Tabaczynski, Leslie Curtin, Mukund Seshadri, Drew R. Jones, Sandra Sexton   +7 more
doaj   +1 more source

Different responses to glucose overload between two strains of largemouth bass (Micropterus salmoides)

Frontiers in Physiology, 2022
In order to improve the glucose utilization capacity of largemouth bass (Micropterus salmoides), responses to glucose overload between two strains (Y: breeding strain; W: wild strain) were compared at 0, 6, 12, and 24 h after glucose injection (1.67 g/kg)
Caixia Lei, Caixia Lei, Yujing Xie, Yujing Xie, Hongmei Song, Peng Jiang, Jinxing Du, Shengjie Li   +7 more
doaj   +1 more source

alpha-Ketoglutarate dehydrogenase complex of Escherichia coli. A hybrid complex containing pyruvate dehydrogenase subunits from pyruvate dehydrogenase complex.

Journal of Biological Chemistry, 1985
The alpha-ketoglutarate dehydrogenase complex of Escherichia coli utilizes pyruvate as a poor substrate, with an activity of 0.082 units/mg of protein compared with 22 units/mg of protein for alpha-ketoglutarate. Pyruvate fully reduces the FAD in the complex and both alpha-keto[5-14C]glutarate and [2-14C]pyruvate fully [14C] acylate the lipoyl groups ...
C A, Steginsky, K J, Gruys, P A, Frey
openaire   +2 more sources

Changes in mitochondrial function in patients with neuromyelitis optica; correlations with motor and cognitive disabilities.

PLoS ONE, 2020
BackgroundNeuromyelitis Optica (NMO) is an inflammatory demyelinating disease that mainly affects optic nerves and spinal cord. Besides, loss of motor and cognitive function has been reported as important symptoms of disease.ObjectiveHere we investigated
Forough Foolad, Fariba Khodagholi, Seyed Massood Nabavi, Mohammad Javan   +3 more
doaj   +1 more source

Understanding the Role of Estrogen Receptor Status in PRODH/POX-Dependent Apoptosis/Survival in Breast Cancer Cells

Biology, 2021
It has been suggested that activation of estrogen receptor α (ER α) stimulates cell proliferation. In contrast, estrogen receptor β (ER β) has anti-proliferative and pro-apoptotic activity.
Sylwia Lewoniewska, Ilona Oscilowska, Antonella Forlino, Jerzy Palka   +3 more
doaj   +1 more source

Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species

International Journal of Cell Biology, 2012
Reduced activity of brain α-ketoglutarate dehydrogenase complex (KGDHC) occurs in a number of neurodegenerative diseases like Parkinson's disease and Alzheimer's disease.
Nikolaus Berndt, Sascha Bulik, Hermann-Georg Holzhütter   +2 more
doaj   +1 more source

Changes in cardiac substrate transporters and metabolic proteins mirror the metabolic shift in patients with aortic stenosis.

PLoS ONE, 2011
In the hypertrophied human heart, fatty acid metabolism is decreased and glucose utilisation is increased. We hypothesized that the sarcolemmal and mitochondrial proteins involved in these key metabolic pathways would mirror these changes, providing a ...
Lisa C Heather, Neil J Howell, Yaso Emmanuel, Mark A Cole, Michael P Frenneaux, Domenico Pagano, Kieran Clarke   +6 more
doaj   +1 more source