Results 51 to 60 of about 22,770 (160)

Expression of Mitochondrial Branched-Chain Aminotransferase and α-Keto-Acid Dehydrogenase in Rat Brain: Implications for Neurotransmitter Metabolism

Frontiers in Neuroanatomy, 2012
In the brain, metabolism of the essential branched chain amino acids (BCAAs) leucine, isoleucine and valine, is regulated in part by protein synthesis requirements. Excess BCAAs are catabolized or excreted. The first step in BCAA catabolism is catalyzed
Jeffrey Thomas Cole, Andrew J Sweatt, Susan M Hutson   +2 more
doaj   +1 more source

dldhcri3 zebrafish exhibit altered mitochondrial ultrastructure, morphology, and dysfunction partially rescued by probucol or thiamine

JCI Insight
Dihydrolipoamide dehydrogenase (DLD) deficiency is a recessive mitochondrial disease caused by variants in DLD, the E3 subunit of mitochondrial α-keto (or 2-oxo) acid dehydrogenase complexes.
Manuela Lavorato, Donna Iadarola, Cristina Remes, Prabhjot Kaur, Chynna Broxton, Neal D. Mathew, Rui Xiao, Christoph Seiler, Eiko Nakamaru-Ogiso, Vernon E. Anderson, Marni J. Falk   +10 more
doaj   +1 more source

Structural Analysis of Phosphoserine Aminotransferase (Isoform 1) From Arabidopsis thaliana– the Enzyme Involved in the Phosphorylated Pathway of Serine Biosynthesis

Frontiers in Plant Science, 2018
Phosphoserine aminotransferase (PSAT) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the conversion of 3-phosphohydroxypyruvate (3-PHP) to 3-phosphoserine (PSer) in an L-glutamate (Glu)-linked reversible transamination reaction.
Bartosz Sekula, Milosz Ruszkowski, Zbigniew Dauter   +2 more
doaj   +1 more source

The upregulation of thiamine (vitamin B₁) biosynthesis in Arabidopsis thaliana seedlings under salt and osmotic stress conditions is mediated by abscisic acid at the early stages of this stress response

BMC Plant Biology, 2012
Background Recent reports suggest that vitamin B1 (thiamine) participates in the processes underlying plant adaptations to certain types of abiotic and biotic stress, mainly oxidative stress.
Rapala-Kozik Maria, Wolak Natalia, Kujda Marta, Banas Agnieszka K   +3 more
doaj   +1 more source

Identification of Pyrrolizilactone Biosynthetic Gene Cluster with Unique Short‐Chain Dehydrogenase Gene for 3‐Methylproline Formation

ChemistryEurope
Natural products often incorporate nonproteogenic amino acids for diversifying their chemical structures and biological activities. Methylproline is one such building block found in bioactive natural products.
Naoki Kato, Sayaka Hirosawa, Toshihiko Nogawa, Kiyomi Kinugasa, Tohru Taniguchi, Hiroyuki Osada, Shunji Takahashi   +6 more
doaj   +1 more source

The α-Ketoglutarate Dehydrogenase Complex as a Hub of Plasticity in Neurodegeneration and Regeneration. [PDF]

Int J Mol Sci, 2022
Hansen GE, Gibson GE.
europepmc   +1 more source

Ultraviolet Spectrophotometric Characterization of a Glutamate Dehydrogenase-reduced Coenzyme-α-Ketoglutarate Complex

Journal of Biological Chemistry, 1972
Abstract Glutamate dehydrogenase binds α-ketoglutarate and TPNH in a ternary complex such that both ligands are more tightly bound than in binary complexes. TPNH, bound in this ternary complex, absorbs maximally at 332 nm with E332 = 5.2 mm-1 cm-1 in contrast to the absorbance of "free" TPNH (E339 = Emax = 6.2 mm-1 cm-1) and TPNH bound in either a ...
openaire   +2 more sources

Alpha-ketoglutarate dehydrogenase complex of Acetobacter xylinum. Purification and regulatory properties.

Journal of Biological Chemistry, 1977
The alpha-ketoglutarate dehydrogenase complex of Acetobacter xylinum was purified to homogeneity. It consists of three main polypeptide chains with a total molecular weight of about 2.4 X 10(6). It catalyzes the overall Mg2+ and thiamin pyrophosphate-dependent, NAD+- and CoA-linked oxidative decarboxylation of alpha-ketoglutarate, as well as the ...
S, Kornfeld, M, Benziman, Y, Milner
openaire   +2 more sources

Structural and transcriptional analysis of plant genes encoding the bifunctional lysine ketoglutarate reductase saccharopine dehydrogenase enzyme

BMC Plant Biology, 2010
Background Among the dietary essential amino acids, the most severely limiting in the cereals is lysine. Since cereals make up half of the human diet, lysine limitation has quality/nutritional consequences. The breakdown of lysine is controlled mainly by
Gu Yong Q, Coleman-Derr Devin, Anderson Olin D, Heath Sekou   +3 more
doaj   +1 more source

Targeting mitochondrial metabolism with CPI-613 in chemoresistant ovarian tumors

Journal of Ovarian Research
Background There is evidence indicating that chemoresistance in tumor cells is mediated by the reconfiguration of the tricarboxylic acid cycle, leading to heightened mitochondrial activity and oxidative phosphorylation (OXPHOS). Previously, we have shown
Mary P. Udumula, Faraz Rashid, Harshit Singh, Tim Pardee, Sanjeev Luther, Tanya Bhardwaj, Km Anjaly, Sofia Piloni, Miriana Hijaz, Radhika Gogoi, Philip A. Philip, Adnan R. Munkarah, Shailendra Giri, Ramandeep Rattan   +13 more
doaj   +1 more source