Results 21 to 30 of about 1,365 (197)

Effect of antimicrobial stewardship on antimicrobial prescriptions for selected diseases of dogs in Switzerland

Journal of Veterinary Internal Medicine, Volume 34, Issue 6, Page 2418-2431, November/December 2020., 2020
Abstract Background Antimicrobial stewardship programs (ASPs) are important tools to foster prudent antimicrobial use. Objective To evaluate antimicrobial prescriptions by Swiss veterinarians before and after introduction of the online ASP AntibioticScout.ch in December 2016.
Claudia Lehner, Alina Hubbuch, Kira Schmitt, Gertraud Schuepbach‐Regula, Barbara Willi, Meike Mevissen, Ruth Peter, Cedric R. Muentener, Hanspeter Naegeli, Simone Schuller   +9 more
wiley   +1 more source

In Vitro ADME, Preclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of RBx14255, a Novel Ketolide with Pharmacodynamics Against Multidrug-Resistant Bacterial Pathogens

Journal of Pharmacy & Pharmaceutical Sciences, 2020
Purpose: The preclinical pharmacokinetic and pharmacodynamic properties of a potent fluoroketolide RBx14255 against Streptococcus pneumoniae and Haemophilus influenzae was compared with telithromycin and human clinical dose was predicted for preclinical ...
Trdib Chaira, Tarani Barman, VETHAKKANI SAMUEL RAJ   +2 more
doaj   +1 more source

Antimicrobial prescriptions and adherence to prudent use guidelines for selected canine diseases in Switzerland in 2016

Veterinary Record Open, Volume 7, Issue 1, 2020., 2020
Background Antimicrobial resistance is an increasing problem in human and veterinary medicine and is closely linked to the use of antimicrobials. The objective of this study was to describe antimicrobial prescriptions for selected canine diseases in Switzerland during 2016. Methods Dogs presented to two university hospitals and 14 private practices for
Bérénice Lutz, Claudia Lehner, Kira Schmitt, Barbara Willi, Gertraud Schüpbach, Meike Mevissen, Ruth Peter, Cedric Müntener, Hanspeter Naegeli, Simone Schuller   +9 more
wiley   +1 more source

Combinatorial biosynthesis of 5-O-desosaminyl erythronolide A as a potent precursor of ketolide antibiotics

, 2021
Ketolides, characterized by possessing a 3-keto group in place of the l-cladinose moiety of erythromycin A, are the recent generation of antimicrobials derived semi-synthetically from the 14-membered ring macrolide erythromycin A.
윤여준
core   +1 more source

Macrolides and Ketolides

, 2014
Macrolides and ketolides are characterized by a very wide tissular distribution, which is related to their capacity to accumulate in the acidic compartments of the cells.
Van Bambeke, Françoise
core   +1 more source

Ketolide Resistance Conferred by Short Peptides [PDF]

Journal of Biological Chemistry, 1998
Clones expressing pentapeptides conferring resistance to a ketolide antibiotic, HMR3004, were selected from a random pentapeptide mini-gene library. The pentapeptide MRFFV conferred the highest level of resistance and was encoded in three different mini-genes. Comparison of amino acid sequences of peptides conferring resistance to a ketolide with those
S, Tripathi, P S, Kloss, A S, Mankin
openaire   +2 more sources

Mutation at the position 2058 of the 23S rRNA as a cause of macrolide resistance in Streptococcus pyogenes

Annals of Clinical Microbiology and Antimicrobials, 2004
Background In streptococci, three macrolide resistance determinants (erm(B), erm(TR) and mef(A)) have been found. In addition, certain mutations at the ribosomal 23S RNA can cause resistance to macrolides. Mutation at the position 2058 of the 23S rRNA of
Huovinen Pentti, Vaara Martti, Jalava Jari   +2 more
doaj   +1 more source

New therapeutic approaches for treatment of tularaemia: a review

Frontiers in Cellular and Infection Microbiology, 2014
Antibiotic treatment of tularaemia is based on a few drugs, including the fluoroquinolones, the tetracyclines and the aminoglycosides. Because no effective and safe vaccine is currently available, tularaemia prophylaxis following proven exposure to F ...
Sandrine eBOISSET, Sandrine eBOISSET, Yvan eCASPAR, Yvan eCASPAR, Vivien eSUTERA, Vivien eSUTERA, Max eMAURIN, Max eMAURIN   +7 more
doaj   +1 more source

Synthesis and Antibacterial Activity of 6-O-Arylbutynyl Ketolides with Improved Activity against Some Key Erythromycin-Resistant Pathogens

, 2016
A series of novel 6-O-substituted homopropargyl ketolides was synthesized and evaluated against various erythromycin-resistant pathogens.
Angela M. Nilius (2531995), Erika E. Englund (3016317), Justin J. Carter (2691442), Melissa M. Daly (3016323), Robert F. Keyes (2501485), Zhenkun Ma (798844), Greg G. Stone (3016320)   +6 more
core   +1 more source

In Vitro Pharmacodynamic Studies of Activities of Ketolides HMR 3647 (Telithromycin) and HMR 3004 against Extracellular or Intracellular Helicobacter pylori

, 2001
The pharmacodynamic properties of the ketolides HMR 3647 (telithromycin) and HMR 3004 were studied against Helicobacter pylori .
I. Gustafsson, L. Engstrand, Gustafsson, I, O. Cars, Cars, O, Engstrand, L,   +5 more
core   +1 more source