Results 41 to 50 of about 1,365 (197)
Type III Secretion-Dependent Sensitivity of Escherichia coli O157 to Specific Ketolides [PDF]
, 2015 A subset of Gram negative bacterial pathogens use a type 3 secretion system (T3SS) to open up a conduit into eukaryotic cells in order to inject effector proteins. These modulate pathways to enhance bacterial colonization.
Tahoun, Amin +11 more
core +1 more source
Fundamental &Clinical Pharmacology, Volume 38, Issue 5, Page 988-997, October 2024.Abstract Background Hypersensitivity reactions (HSR) are reported for the macrolides, lincosamides, and streptogramins (MLS) antibiotic family. Data about cross‐reactivity among and between MLS remain scarce or controversial. Objectives The aim of this study was to provide an overview of hypersensitivity cross‐reactions among MLSs based on data ...
Quentin Le Baron +9 more
wiley +1 more source
EFSA Journal, Volume 15, Issue 10, October 2017., 2017 Abstract ECDC, EFSA and EMA have jointly established a list of harmonised outcome indicators to assist EU Member States in assessing their progress in reducing the use of antimicrobials and antimicrobial resistance (AMR) in both humans and food‐producing animals. The proposed indicators have been selected on the basis of data collected by Member States
ECDC +2 more
wiley +1 more source
Synthesis of Novel 6,11-O-Bridged Bicyclic Ketolides via a Palladium-Catalyzed Bis-allylation
, 2016 A bridging chemistry process was developed to form an ether bridge between 6-O and 11-O of erythromycin A via a tandem or stepwise palladium-catalyzed bis-π-allylation.
Ly Tam Phan (2701579) +6 more
core +1 more source
The antibiotic resistance crisis and the development of new antibiotics
Microbial Biotechnology, Volume 17, Issue 7, July 2024.The current Lilliput review analyses the question whether scientific or economic hurdles prevented the registration of new antibiotics. Scientifically, substantial progress has been achieved over recent years. The lack of profitability for costly novel antibiotic development necessitates push and pull efforts of the public sector to complement what the
Harald Brüssow
wiley +1 more source
South African actinobacteria: A treasure trove of novel bioactive metabolites for drug discovery
South African Journal of ScienceAlthough South Africa is known as one of the most biodiverse countries in the world, based on its unique plants and animals, microorganisms have received much less attention.
Kojo S. Acquah +2 more
doaj +1 more source
, 2016 In the search for new antibiotics active against macrolide-resistant pneumococci and Haemophilus influenzae, we synthesized a new class of 3-oxo-6-O-methylerythromycin derivatives, so-called “ketolides”. A keto function was introduced in position 3 after
Arlette Dussarat (3022353) +14 more
core +1 more source
What is the role of microbial biotechnology and genetic engineering in medicine?
MicrobiologyOpen, Volume 13, Issue 2, April 2024.Microbial biotechnology, the technological application of microorganisms, has been instrumental in producing significant natural bioactive products. These include antibiotics, antifungals, anticancer drugs, antiparasitics, antivirals, immunosuppressants, toxoid vaccines, and therapeutic enzymes.
Fernando Santos‐Beneit
wiley +1 more source
, 2016 Respiratory tract bacterial strains are becoming increasingly resistant to currently marketed macrolide antibiotics. The current alternative telithromycin (1) from the newer ketolide class of macrolides addresses resistance but is hampered by serious ...
Joseph B. Penzien (2201149) +37 more
core +1 more source
In Vitro Activity of the Ketolide ABT-773 [PDF]
Antimicrobial Agents and Chemotherapy, 2001 ABSTRACT The in vitro activities of ABT-773, azithromycin, erythromycin, and clindamycin were compared by testing 1,223 clinical isolates selected to represent different species and phenotypes. ABT-773 was particularly potent against staphylococci (the MIC at which 90% of the strains tested were inhibited [MIC 90
A L, Barry, P C, Fuchs, S D, Brown
openaire +2 more sources