Results 71 to 80 of about 1,293 (183)

Phylogenetic sequence variations in bacterial rRNA affect species-specific susceptibility to drugs targeting protein synthesis [PDF]

open access: yes, 2011
Antibiotics targeting the bacterial ribosome typically bind to highly conserved rRNA regions with only minor phylogenetic sequence variations. It is unclear whether these sequence variations affect antibiotic susceptibility or resistance development.
Erik C. Böttger   +13 more
core   +1 more source

The Natural Ketolides Methymycin and Pikromycin: Binding Sites, Modes of Action, Mechanisms of Resistance [PDF]

open access: yes, 2015
Ketolides are promising new antimicrobials effective against a broad range of Gram-positive pathogens, due in part to the low propensity of these drugs to trigger the expression of resistance genes.
Mashal M. Almutairi (5638046)
core  

The slow dissociation rate of K-1602 contributes to the enhanced inhibitory activity of this novel alkyl-aryl-bearing fluoroketolide [PDF]

open access: yes, 2016
Ketolides belong to the latest generation of macrolides and are not only effective against macrolide susceptible bacterial strains but also against some macrolide resistant strains.
Stavropoulou, M.   +4 more
core  

Expert consensus on monitoring antimicrobial stewardship in French nursing homes using assessed reimbursement database indicators. [PDF]

open access: yesJAC Antimicrob Resist, 2023
Asquier-Khati A   +5 more
europepmc   +1 more source

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