Results 151 to 160 of about 1,365 (197)

Ketolides: the future of the macrolides?

Current Opinion in Pharmacology, 2002
The prevalence of antibiotic resistance in bacterial pathogens associated with community-acquired respiratory tract infections is increasing. Ketolides, semi-synthetic derivatives of erythromycin, overcome the macrolide resistance mechanisms found in Streptococcus pneumoniae and Streptococcus pyogenes, two key pathogens. They also have improved potency
Angela M, Nilius, Zhenkun, Ma
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Recent developments in macrolides and ketolides

Current Opinion in Microbiology, 1999
Emergence of bacterial resistance to macrolide antibiotics, particularly in Gram-positive bacteria, has been observed. Novel macrolides having C-4" carbamate functional groups and ketolides, the 3-keto derivatives of macrolides, have been found to have activities against macrolide-resistant strains.
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Macrolides and Ketolides

2013
Macrolides and ketolides are characterized by a very wide tissular distribution, which is related to their capacity to accumulate in the acidic compartments of the cells. This property is considered an advantage, because it concentrates the drug at the site of infection.
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Telithromycin: An Oral Ketolide for Respiratory Infections

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2001
The ketolides represent a new subclass of antibiotics among the macrolide‐lincosamide‐streptogramin group. Telithromycin, the first ketolide to be awarded approvable status for clinical use, demonstrates in vitro activity against community‐acquired respiratory pathogens including penicillin‐ and erythromycin‐resistant Streptococcus pneumoniae.
D T, Bearden, M M, Neuhauser, K W, Garey
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ABT-773: a new ketolide antibiotic

Expert Opinion on Investigational Drugs, 2001
ABT-773 is a new semisynthetic derivative of erythromycin A, the ketolide class of broad spectrum antibacterial agents, in Phase II development by Abbott. With good broad spectrum activity against Gram-positive, some Gram-negative organisms and intracellular bacteria, ABT-773 is being developed as a respiratory agent. Structural changes in the ketolide
T J, Dougherty, J F, Barrett
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Review of Macrolides and Ketolides

Drugs, 2001
The first macrolide, erythromycin A, demonstrated broad-spectrum antimicrobial activity and was used primarily for respiratory and skin and soft tissue infections. Newer 14-, 15- and 16-membered ring macrolides such as clarithromycin and the azalide, azithromycin, have been developed to address the limitations of erythromycin.
G G, Zhanel, M, Dueck, D J, Hoban, L M, Vercaigne, J M, Embil, A S, Gin, J A, Karlowsky   +6 more
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Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics

Bioorganic & Medicinal Chemistry Letters, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Todd C, Henninger, Xiaodong, Xu, Darren, Abbanat, Ellen Z, Baum, Barbara D, Foleno, Jamese J, Hilliard, Karen, Bush, Dennis J, Hlasta, Mark J, Macielag   +8 more
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Structure-Activity Relationships for Six Ketolide Antibiotics

Current Microbiology, 2001
Six structurally related 3-keto-substituted macrolide antibiotics (ketolides) were compared for concentration-dependent inhibitory effects on growth rate, viable cell number, and protein synthesis rates in Staphylococcus aureus cells. Inhibitory effects on 50S ribosomal subunit formation were also examined, as this is a second target for these ...
Champney, W. Scott, Tober, Craig L.
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Effects of Macrolides and Ketolides on Mycobacterial Infections

Current Pharmaceutical Design, 2004
New macrolides, such as clarithromycin and azithromycin, are active agents to Mycobacterium avium complex (MAC). Both clarithromycin and azithromycin are well-known for the ability to improve the prognosis of AIDS patients with disseminated MAC infection.
Luiz E, Bermudez, Yoshitaka, Yamazaki
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The Emerging New Generation of Antibiotic: Ketolides

Current Drug Targets - Infectious Disorders, 2001
The bacterial ribosome is a target for a variety of drug classes including macrolides. Macrolide antibiotics are primarily used for the treatment of respiratory tract infections. One of the most important features of the macrolide class is the excellent safety profile allowing the drug to be used broadly across all age groups.
P, Zhong, V, Shortridge
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