Results 101 to 110 of about 1,080 (156)
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Recent Developments on Ketolides and Macrolides
Current Medicinal Chemistry, 2001Recent semi-synthetic studies of erythromycin A culminated in the discovery of two ketolide drug candidates, HMR-3647 and ABT-773, for the treatment of community-acquired bacterial infections caused by both macrolide- and beta-lactam-susceptible and -resistant S. pneumoniae, gram negative bacteria, and intracellular atypical pathogens. The discovery of
Y J, Wu, W G, Su
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Novel tethers in ketolide antibiotics
Bioorganic & Medicinal Chemistry Letters, 2007Novel macrolide antibiotics which contain a methylene unit between two nitrogen atoms of carbamate groups or between two nitrogen atoms of one carbamate and one urea group were synthesized using the Curtius rearrangement. Such linkers were shown to be stable under physiological conditions, and the resulting ketolides show potent in vitro and in vivo ...
Takushi, Kaneko +3 more
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Cethromycin: A New Ketolide Antibiotic
Annals of Pharmacotherapy, 2013OBJECTIVE To review the pharmacology, chemistry, microbiology, in vitro susceptibility, mechanism of resistance, pharmacokinetics, pharmacodynamics, clinical efficacy, safety, drug interactions, dosage, and administration of cethromycin, a new ketolide antibiotic.
Mansour, Hanine +3 more
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Telithromycin: The first ketolide antimicrobial
Clinical Therapeutics, 2005Telithromycin is the first of the ketolide antibacterials to receive US Food and Drug Administration (FDA) approval for clinical use. It is approved for the treatment of community-acquired pneumonia (CAP), acute exacerbations of chronic bronchitis (AECB), and acute maxillary sinusitis (AMS) in adults.This article reviews the mechanism of action, in ...
Megan, Nguyen, Eunice P, Chung
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Solithromycin: A novel ketolide antibiotic
American Journal of Health-System Pharmacy, 2017The pharmacology, pharmacokinetics, pharmacodynamics, antimicrobial activity, clinical safety, and current regulatory status of solithromycin are reviewed.Solithromycin is a novel ketolide antibiotic developed for the treatment of community-acquired bacterial pneumonia (CABP).
Buege, Michael J. +2 more
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Ketolides in the treatment of respiratory infections
Expert Opinion on Pharmacotherapy, 2002The ketolides are a new class of macrolides specifically designed to combat respiratory tract pathogens that have acquired resistance to macrolides. The ketolides are semi-synthetic derivatives of the 14-membered macrolide erythromycin A. There are currently two ketolides in the late stages of clinical development in the US (telithromycin [HMR-364 ...
George G, Zhanel, Daryl J, Hoban
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2011
The macrolides and ketolides represent a class of antibacterial agents with activities against most Gram-positive and selected Gram-negative as well as atypical pathogens including penicillin-resistant microorganisms. Erythromycin, clarithromycin, and azithromycin, the most extensively used macrolides in North America, and the only approved ketolide ...
Ze-Qi Xu +2 more
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The macrolides and ketolides represent a class of antibacterial agents with activities against most Gram-positive and selected Gram-negative as well as atypical pathogens including penicillin-resistant microorganisms. Erythromycin, clarithromycin, and azithromycin, the most extensively used macrolides in North America, and the only approved ketolide ...
Ze-Qi Xu +2 more
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Recent developments in macrolides and ketolides
Current Opinion in Microbiology, 1999Emergence of bacterial resistance to macrolide antibiotics, particularly in Gram-positive bacteria, has been observed. Novel macrolides having C-4" carbamate functional groups and ketolides, the 3-keto derivatives of macrolides, have been found to have activities against macrolide-resistant strains.
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Ketolides: the future of the macrolides?
Current Opinion in Pharmacology, 2002The prevalence of antibiotic resistance in bacterial pathogens associated with community-acquired respiratory tract infections is increasing. Ketolides, semi-synthetic derivatives of erythromycin, overcome the macrolide resistance mechanisms found in Streptococcus pneumoniae and Streptococcus pyogenes, two key pathogens. They also have improved potency
Angela M, Nilius, Zhenkun, Ma
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2013
Macrolides and ketolides are characterized by a very wide tissular distribution, which is related to their capacity to accumulate in the acidic compartments of the cells. This property is considered an advantage, because it concentrates the drug at the site of infection.
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Macrolides and ketolides are characterized by a very wide tissular distribution, which is related to their capacity to accumulate in the acidic compartments of the cells. This property is considered an advantage, because it concentrates the drug at the site of infection.
openaire +1 more source