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Ketone bodies: from enemy to friend and guardian angel

BMC Medicine, 2021
During starvation, fasting, or a diet containing little digestible carbohydrates, the circulating insulin levels are decreased. This promotes lipolysis, and the breakdown of fat becomes the major source of energy.
H. Kolb, K. Kempf, M. Röhling, Martina Lenzen-Schulte, N. Schloot, Stephan Martin   +5 more
semanticscholar   +1 more source

Ketone supplementation abolished isoflurane anesthesia-induced elevation in blood glucose level and increased recovery time from anesthesia in Wistar Albino Glaxo Rijswijk rats

BMC Anesthesiology, 2023
Background It has been suggested that administration of exogenous ketone supplements (EKSs) not only increases blood ketone body levels but also decreases blood glucose level and modulates isoflurane-induced anesthesia in different rodents, such as ...
Zsolt Kovács, Dominic P. D’Agostino, Csilla Ari   +2 more
doaj   +1 more source

Metabolic and Signaling Roles of Ketone Bodies in Health and Disease.

Annual review of nutrition, 2021
Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during states of low carbohydrate availability. Efforts to enhance wellness and
Patrycja Puchalska, P. Crawford
semanticscholar   +1 more source

SGLT2 Inhibitors and Ketone Metabolism in Heart Failure

Journal of Lipid and Atherosclerosis, 2022
Sodium-glucose cotransporter-2 (SGLT2) inhibitors have emerged as powerful drugs that can be used to treat heart failure (HF) patients, both with preserved and reduced ejection fraction and in the presence or absence of type 2 diabetes.
Huitizilihuitl Saucedo-Orozco, S. Voorrips, Salva R. Yurista, R. D. de Boer, B. Westenbrink   +4 more
semanticscholar   +1 more source

Ruthenacycles and Iridacycles as Transfer Hydrogenation Catalysts

Molecules, 2021
In this review, we describe the synthesis and use in hydrogen transfer reactions of ruthenacycles and iridacycles. The review limits itself to metallacycles where a ligand is bound in bidentate fashion to either ruthenium or iridium via a carbon–metal ...
Vincent Ritleng, Johannes G. de Vries
doaj   +1 more source

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

Journal of Medicinal Chemistry, 2020
The novel coronavirus disease COVID-19 that emerged in 2019 is caused by the virus SARS CoV-2 and named for its close genetic similarity to SARS CoV-1 that caused severe acute respiratory syndrome (SARS) in 2002.
R. Hoffman, R. Kania, M. A. Brothers, J. Davies, R. Ferre, K. Gajiwala, Mingying He, R. Hogan, K. Kozminski, Lilian Y. Li, Jonathan W Lockner, J. Lou, M. Marra, L. J. Mitchell, B. Murray, J. Nieman, Stephen Noell, Simon Planken, T. Rowe, K. Ryan, George J. Smith, J. Solowiej, C. Steppan, Barbara Taggart   +23 more
semanticscholar   +1 more source

Metabolic and Immunological Effects of Intermittent Fasting on a Ketogenic Diet Containing Medium-Chain Triglycerides in Healthy Dogs

Frontiers in Veterinary Science, 2020
In several species, intermittent fasting (IF) has been shown to have beneficial effects, including delayed aging, increased lifespan, increased insulin sensitivity, reduced ischemic tissue damage, delayed onset of neurodegenerative disease and improved ...
Y. Becca Leung, Nick J. Cave, Axel Heiser, Patrick J. B. Edwards, A. Jonathan R. Godfrey, Tim Wester   +5 more
doaj   +1 more source

Short-Chain Fatty Acids Outpace Ketone Oxidation in the Failing Heart

Circulation, 2021
Supplemental Digital Content is available in the text. Background: The failing heart is energy starved with impaired oxidation of long-chain fatty acids (LCFAs) at the level of reduced CPT1 (carnitine palmitoyltransferase 1) activity at the outer ...
Andrew N. Carley, S. Maurya, Matthew Fasano, Yang Wang, C. Selzman, S. Drakos, E. Lewandowski   +6 more
semanticscholar   +1 more source

(2-Hydroxyphenyl)(4,2′:4′,4′′-terpyridin-6′-yl)methanone

IUCrData, 2020
The title compound, C22H15N3O2, can be described as a ketone with a phenol substituent and a terpyridine ligand coordinated to the carbonyl group. The three six-membered rings of the terpyridine ligand are not coplanar.
S. Devika, Noor Shahina Begum, Kiran B. Manjappa, Ding-Yah Yang   +3 more
doaj   +1 more source

Anti-Tumor Effects of BDH1 in Acute Myeloid Leukemia

Frontiers in Oncology, 2021
Dysregulation of ketone metabolism has been reported in various types of cancer. In order to find out its role in acute myeloid leukemia (AML) pathogenesis, we first analyzed the expression levels of 10 key genes involved in ketone metabolism in AML ...
Fei Han, Fei Han, Fei Han, Huanhuan Zhao, Huanhuan Zhao, Huanhuan Zhao, Jun Lu, Jun Lu, Jun Lu, Weina Yun, Weina Yun, Weina Yun, Lingling Yang, Lingling Yang, Lingling Yang, Yude Lou, Yude Lou, Yude Lou, Dan Su, Dan Su, Dan Su, Xin Chen, Xin Chen, Xin Chen, Shixuan Zhang, Shixuan Zhang, Shixuan Zhang, Hanwei Jin, Hanwei Jin, Hanwei Jin, Xiang Li, Xiang Li, Xiang Li, Jie Sun, Jie Sun, He Huang, He Huang, He Huang, Qishan Wang, Xi Jiang, Xi Jiang, Xi Jiang   +41 more
doaj   +1 more source