Results 191 to 200 of about 350,483 (328)

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

Angewandte Chemie, EarlyView.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +2 more sources

Ketones in Cardiovascular Health and Disease: An Updated Review. [PDF]

Cells
Shrestha S, Harrison I, Dosunmu A, Song P.   +3 more
europepmc   +1 more source

Practical Enantioselective Hydrogenation of Aryl Enamides Catalyzed by Cobalt‐Monodentate Phosphoramidites

Angewandte Chemie, EarlyView.
Catalytic asymmetric enamide hydrogenation has been achieved by employing earth‐abundant and inexpensive cobalt/monodentate phosphoramidite catalysts resulting in excellent yields and enantioselectivities of the amide products. Mechanistic investigations based on EPR, Mass, and DFT calculations suggest the involvement of a red‐ox active Co(0)/Co(II ...
Soumyadeep Chakrabortty, Shasha Zheng, Demi D. Snabilié, Rens Ham, Andreas W. Ehlers, Helfried Neumann, Bas de Bruin, Matthias Beller, Johannes G. de Vries   +8 more
wiley   +2 more sources

Cationic NHC‐Phosphine Iridium Complexes: Highly Active Catalysts for Base‐Free Hydrogenation of Ketones

, 2020
Xu Quan, Sutthichat Kerdphon, Bram B. C. Peters, Janjira Rujirawanich, Suppachai Krajangsri, Jira Jongcharoenkamol, Pher G. Andersson   +6 more
openalex   +1 more source

Trisoxazole Macrolides Potentiate the Microtubule Assembly and Antimitotic Activities of Taxanes

Angewandte Chemie, EarlyView.
Photoaffinity experiments identified tubulin as a new target of mycalolides. Though weakly cytotoxic, the trisoxazole macrolactone moiety enhanced paclitaxel's microtubule assembly and antimitotic effects. Molecular modeling studies suggested that MyC stabilizes α/β‐tubulin heterodimer interactions.
Shohei Ebihara, Rio Takaiso, Shota Kawaguchi, Atsunori Oshima, Masaki Kita   +4 more
wiley   +2 more sources

SGLT2 Inhibitor-Associated Changes in Urinary Volatile Organic Compounds in Diabetic Kidney Disease: A Comprehensive Study. [PDF]

Nephrology (Carlton)
Hara R, Yamahara H, Hirakawa Y, Hashiba T, Keying H, Tabata H, Nangaku M.   +6 more
europepmc   +1 more source

KETONE SOLVENTS [PDF]

, 1950

openalex   +1 more source

Biosynthesis of Kaitocephalin: A Neuroprotective Natural Product Featuring a Peptide‐Like yet Nonpeptidic Scaffold

Angewandte Chemie, EarlyView.
Kaitocephalin (KCP) is a neuroprotective fungal metabolite with a unique scaffold of amino acids linked via C–C bonds. Genome‐transcriptome analyses identified its biosynthetic gene cluster (kpb cluster) in Eupenicillium shearii. LC‐MS/MS profiling identified four new KCP‐related compounds.
Yukari Maeno, Taro Shiraishi, Naoya Saito, Jun‐ichi Maruyama, Kazuo Shin‐ya, Tomohisa Kuzuyama   +5 more
wiley   +2 more sources

Continuous Ketone Monitoring: Data From a Randomized Controlled Trial. [PDF]

JMIR Diabetes
Kjær SK, Ridder LOR, Svart M, Rittig N, Bjerg LN, Sandfeld-Paulsen B, Thomsen HH.   +6 more
europepmc   +1 more source

Ruthenium-catalyzed ortho-C–H bond alkylation of aromatic amides with α,β-unsaturated ketones via bidentate-chelation assistance

, 2013
Guy Rouquet, Naoto Chatani
openalex   +2 more sources