Results 1 to 10 of about 52,379 (262)

SLC16a6, mTORC1, and Autophagy Regulate Ketone Body Excretion in the Intestinal Cells

Biology, 2023
Ketone bodies serve several functions in the intestinal epithelium, such as stem cell maintenance, cell proliferation and differentiation, and cancer growth.
Takashi Uebanso, Moeka Fukui, Chisato Naito, Takaaki Shimohata, Kazuaki Mawatari, Akira Takahashi   +5 more
doaj   +1 more source

Metabolic markers of short and long-term exogenous DL-beta-hydroxybutyrate supplementation in episodic migraine patients: an exploratory analysis of a randomized-controlled-trial

Frontiers in Pharmacology, 2023
Background: Emerging findings propose that the pathophysiology of migraine may be associated with dysfunctional metabolic mechanisms. Recent findings suggest that migraine attacks are a response to the cerebral energy deficit, and ingestion of ketone ...
Niveditha Putananickal, Elena C. Gross, Anna-Lena Orsini, Simone Schmidt, Patricia Hafner, Vanya Gocheva, Sara Nagy, Bettina C. Henzi, Daniela Rubino, Sabine Schädelin, Peter Sandor, Dirk Fischer   +11 more
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Effect of continuous positive urine ketone body on clinical outcomes of pregnant women with gestational diabetes mellitus and newborn

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To explore the effect of continuous positive urine ketone body in pregnant women with gestational diabetes mellitus (GDM) on the maternal and infant outcomes.Methods·A total of 168 GDM pregnant women who attended the Nutrition Clinic of the ...
ZHANG Yue, QU Lei, GU Qin, ZHU Yiqing, MA Liying, SUN Wenguang   +5 more
doaj   +1 more source

Measuring ketone bodies for the monitoring of pathologic and therapeutic ketosis

Obesity Science & Practice, 2021
Background The ketone bodies β‐hydroxybutyrate (BOHB) and acetone are generated as a byproduct of the fat metabolism process. In healthy individuals, ketone body levels are ∼0.1 mM for BOHB and ∼1 part per million for breath acetone (BrAce). These levels
Joseph C. Anderson, Samer G. Mattar, Frank L. Greenway, Richard J. Lindquist   +3 more
doaj   +1 more source

Ketone Body Metabolism in the Ischemic Heart

Frontiers in Cardiovascular Medicine, 2021
Ketone bodies have been identified as an important, alternative fuel source in heart failure. In addition, the use of ketone bodies as a fuel source has been suggested to be a potential ergogenic aid for endurance exercise performance.
Stephen C. Kolwicz
doaj   +1 more source

Elevated Plasma Levels of Ketone Bodies Are Associated With All‐Cause Mortality and Incidence of Heart Failure in Older Adults: The CHS

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Chronic disease, such as heart failure, influences cellular metabolism and shapes circulating metabolites. The relationships between key energy metabolites and chronic diseases in aging are not well understood. This study aims to determine the
Sebastian Niezen, Margery A. Connelly, Calvin Hirsch, Jorge R. Kizer, Maria E. Benitez, Scott Minchenberg, Maria Camila Perez‐Matos, Zhenghui Gordon Jiang, Kenneth J. Mukamal   +8 more
doaj   +1 more source

Cardiac ketone body metabolism

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2020
The ketone bodies, d-β-hydroxybutyrate and acetoacetate, are soluble 4-carbon compounds derived principally from fatty acids, that can be metabolised by many oxidative tissues, including heart, in carbohydrate-depleted conditions as glucose-sparing energy substrates.
Azrul, Abdul Kadir, Kieran, Clarke, Rhys D, Evans   +2 more
openaire   +3 more sources

Ketone body 3-hydroxybutyrate enhances adipocyte function

Scientific Reports, 2022
Ketone bodies, including 3HBA, are endogenous products of fatty acid oxidation, and Hmgcs2 is the first rate-limiting enzyme of ketogenesis. From database analysis and in vivo and in vitro experiments, we found that adipose tissue and adipocytes express ...
Shigeki Nishitani, Atsunori Fukuhara, Issei Tomita, Shinji Kume, Jihoon Shin, Yosuke Okuno, Michio Otsuki, Hiroshi Maegawa, Iichiro Shimomura   +8 more
doaj   +1 more source

Differential Response of Hippocampal and Cerebrocortical Autophagy and Ketone Body Metabolism to the Ketogenic Diet

Frontiers in Cellular Neuroscience, 2021
Experimental and clinical data support the neuroprotective properties of the ketogenic diet and ketone bodies, but there is still a lot to discover to comprehensively understand the underlying mechanisms. Autophagy is a key mechanism for maintaining cell
Daniela Liśkiewicz, Arkadiusz Liśkiewicz, Marta M. Nowacka-Chmielewska, Mateusz Grabowski, Mateusz Grabowski, Natalia Pondel, Konstancja Grabowska, Konstancja Grabowska, Sebastian Student, Sebastian Student, Jaroslaw J. Barski, Jaroslaw J. Barski, Andrzej Małecki   +12 more
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HMGCS2 Mediation of Ketone Levels Affects Sorafenib Treatment Efficacy in Liver Cancer Cells

Molecules, 2022
Primary liver cancer is the fifth leading death of cancers in men, and hepatocellular carcinoma (HCC) accounts for approximately 90% of all primary liver cancer cases. Sorafenib is a first-line drug for advanced-stage HCC patients.
Fat-Moon Suk, Chien-Ying Wu, Wan-Chun Chiu, Chia-Ying Chien, Tzu-Lang Chen, Yi-Jen Liao   +5 more
doaj   +1 more source