Results 101 to 110 of about 52,379 (262)

Pharmacometabolomics reveals racial differences in response to atenolol treatment. [PDF]

, 2013
Antihypertensive drugs are among the most commonly prescribed drugs for chronic disease worldwide. The response to antihypertensive drugs varies substantially between individuals and important factors such as race that contribute to this heterogeneity ...
Beitelshees, Amber L, Boyle, Stephen, Chapman, Arlene B, Churchill, Erik, Cooper-Dehoff, Rhonda M, Fiehn, Oliver, Frye, Reginald F, Gong, Yan, Johnson, Julie A, Kaddurah-Daouk, Rima, Pharmacometabolomics Research Network, Wikoff, William R, Zhu, Hongjie   +12 more
core   +2 more sources

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

Inborn Errors of Ketone Body Metabolism and Transport

Journal of Inborn Errors of Metabolism and Screening, 2018
Major progress occurred in understanding inborn errors of ketone body transport and metabolism between the International Congresses on Inborn Errors of Metabolism in Barcelona (2013) and Rio de Janeiro (2017).
Jörn Oliver Sass Dr. rer. nat., Toshiyuki Fukao MD, PhD, Grant A. Mitchell MD   +2 more
doaj   +1 more source

Baboon-to-human liver transplantation [PDF]

, 1993
Our ability to control both the cellular and humoral components of xenograft rejection in laboratory experiments, together with an organ shortage that has placed limits on clinical transplantation services, prompted us to undertake a liver ...
A Tzakis, A Zeevi, A Zeevi, A.J Demetris, A.J Demetris, Alper, Asonuma, Bailey, Barnard, Cano, Crawford, Essex, Francavilla, H Doyle, Hasan, Hitchcock, I.R Marino, Iwaki, J Fung, Jacobson, Karpas, Kelly, M Michaels, M Trucco, M Trucco, Moran, Porter, S Kusne, S Kusne, S Todo, Starzl, Starzl, Starzl, Starzl, Starzl, T.E Starzl, Takaya, Todo, Tzakis, V Warty, V Warty, W.A Rudert, W.A Rudert, Wolpl   +43 more
core   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Flexible Memory: Progress, Challenges, and Opportunities

Advanced Intelligent Discovery, EarlyView.
Flexible memory technology is crucial for flexible electronics integration. This review covers its historical evolution, evaluates rigid systems, proposes a flexible memory framework based on multiple mechanisms, stresses material design's role, presents a coupling model for performance optimization, and points out future directions.
Ruizhi Yuan, Sen Chen, Minghui Guo, Ziliang Cui, Yujie Du, Jing Liu   +5 more
wiley   +1 more source

Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension

Cell Reports, 2018
Summary: Dietary salt reduction and exercise are lifestyle modifications for salt-sensitive hypertensives. While exercise has prominent metabolic effects, salt has an adverse effect on metabolic syndrome, of which hypertension is a hallmark.
Saroj Chakraborty, Sarah Galla, Xi Cheng, Ji-Youn Yeo, Blair Mell, Vishal Singh, BengSan Yeoh, Piu Saha, Anna V. Mathew, Matam Vijay-Kumar, Bina Joe   +10 more
doaj   +1 more source

2-pentanone production from hexanoic acid by Penicillium roqueforti from blue cheese:is this the pathway used in humans? [PDF]

, 2014
Production of 2-pentanone, a methylketone, is increased in fasting ketotic humans. Its origin is unknown. We hypothesised that it is formed via β-oxidation of hexanoic acid by the peroxisomal pathway proposed for methylketone-producing fungi and yeasts ...
Mills, Graham A., Walker, Valerie
core   +2 more sources

Blood Lactate as a Prognostic Biomarker for Survival and Weight Loss in Amyotrophic Lateral Sclerosis: An Exploratory–Validation Study

Annals of Neurology, EarlyView.
Objective Lactate is increasingly recognized as an energy substrate, but its relevance to amyotrophic lateral sclerosis (ALS) remains unclear. We examined whether blood lactate is associated with survival and weight loss in ALS. Methods This retrospective study included an Australian exploratory cohort and a Japanese validation cohort with clinical ...
Ryutaro Nakamura, Frederik J. Steyn, Shuhei Kobashi, Nobuhiro Ogawa, Akihiro Kitamura, Isamu Yamakawa, Robert D. Henderson, Shyuan T. Ngo, Makoto Urushitani   +8 more
wiley   +1 more source

Production of methyl ethyl ketone from biomass using a hybrid biochemical/catalytic approach [PDF]

, 2013
The recent demand for sustainable routes to fuels and chemicals has led to an increased amount of research in conversion of natural resources. A potential approach for conversion of biomass to fuels and chemicals is to combine biochemical and chemical ...
Hohn, Keith L., McGraw, Nathan, Multer, Alisha, Vadlani, Praveen V.   +3 more
core   +2 more sources