Results 211 to 220 of about 52,379 (262)

Performance of an automated insulin‐glucagon delivery system versus automated insulin delivery system during challenging inpatient conditions. A single‐blind randomised controlled crossover trial

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To assess the efficacy and safety of an automated insulin‐glucagon delivery system (AIGD) compared with an automated insulin delivery system (AID). Materials and methods In a 33‐h, randomised, crossover, inpatient study, 13 participants with type 1 diabetes used the DiaCon system in AIGD and AID modes.
Ajenthen G. Ranjan PhD, Christian Laugesen PhD, Dimitri Boiroux PhD, Signe Schmidt PhD, Asbjørn T. Reenberg PhD, Jens Juul Holst DMSc, John B. Jørgensen PhD, Kirsten Nørgaard DMSc   +7 more
wiley   +1 more source

Acarbose or Canagliflozin vs. Placebo to Ameliorate Post‐Bariatric Hypoglycaemia: The Clinical Outcomes of the HypoBar I Randomised Clinical Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Treatment options for post‐bariatric hypoglycaemia (PBH) are empirical. We aimed to investigate the efficacy and safety of acarbose and canagliflozin for the treatment of PBH. Materials and Methods We performed a randomised, double‐blinded, cross‐over, placebo‐controlled clinical trial where placebo, acarbose 50 mg thrice daily, and ...
Carolina B. Lobato, Clara Tornøe Winding, Kirstine N. Bojsen‐Møller, Bolette Hartmann, Christoffer Martinussen, Simon Veedfald, Jens J. Holst, Sten Madsbad, Nils Bruun Jørgensen, Carsten Dirksen   +9 more
wiley   +1 more source

Circulating Rhythmic Metabolites and Causal Risk of Type 2 Diabetes in Adults in the Canadian Longitudinal Study on Aging

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Circadian regulation of metabolism is an important factor in metabolic health, yet the role of rhythmic metabolites in Type 2 diabetes development remains poorly understood. This study investigated associations between circulating rhythmic metabolites and incident Type 2 diabetes risk and evaluated causal relationships using two‐sample ...
Divya Joshi, Talha Rafiq, Marie Pigeyre, Renee de Mutsert, Femke Rutters, David J.T. Campbell, Jean‐Pierre Despres, Andre C. Carpentier, Joris Hoeks, Patrick Schrauwen, Parminder Raina   +10 more
wiley   +1 more source

Incretin and Glucagon Signalling in MASLD and MASH: Integrating Metabolic Pathways With Disease Progression

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) arises from dysregulated interactions between nutrient delivery, adipose tissue lipid handling and liver lipid metabolism, which collectively coalesce to drive inflammatory signalling leading to metabolic dysfunction‐associated steatohepatitis (MASH) and fibrosis. Recent clinical
Evangelia E. Tsakiridis, Gregory R. Steinberg   +1 more
wiley   +1 more source

Beyond Glucose: A Brain Energy Bottleneck Hypothesis for Multi‐Energy Substrates in Hypoglycaemia Rescue

Diabetes, Obesity and Metabolism, EarlyView.
D. Russell‐Jones, M. Laffan, J. Mader
wiley   +1 more source

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Metabolic Messengers: ketone bodies

Nature Metabolism, 2023
Prospective molecular targets and therapeutic applications for ketone body metabolism have increased exponentially in the past decade. Initially considered to be restricted in scope as liver-derived alternative fuel sources during periods of carbohydrate restriction or as toxic mediators during diabetic ketotic states, ketogenesis and ketone bodies ...
Alisa B. Nelson, Eric D. Queathem, Patrycja Puchalska, Peter A. Crawford   +3 more
openaire   +2 more sources

Ketone bodies monitoring

Diabetes Research and Clinical Practice, 2006
Abstract Diabetic ketoacidosis (DK) is a serious acute complication in type 1 diabetic patients caused by insulin deficiency. The early detection of insulin deprivation represents therefore an important element in routine clinical practice, especially in ketone prone subjects such as CSII (continuous subcutaneous insulin infusion) treated subjects ...
Marco Orsini Federici, Massimo Massi Benedetti   +1 more
openaire   +1 more source

Cerebral ketone body metabolism

Journal of Inherited Metabolic Disease, 2004
SummaryKetone bodies (KBs) are an important source of energy for the brain. During the neonatal period, they are also precursors for the synthesis of lipids (especially cholesterol) and amino acids. The rate of cerebral KB metabolism depends primarily on the concentration in blood; high concentrations occur during fasting and on a high‐fat diet ...
openaire   +2 more sources

Ketone bodies as epigenetic modifiers

Current Opinion in Clinical Nutrition & Metabolic Care, 2018
Ketone body metabolism is a dynamic and integrated metabolic node in human physiology, whose roles include but extend beyond alternative fuel provision during carbohydrate restriction. Here we discuss the most recent observations suggesting that ketosis coordinates cellular function via epigenomic regulation.Ketosis has been linked to covalent ...
Hai-Bin, Ruan, Peter A, Crawford
openaire   +2 more sources

Bedside Blood Ketone Body Monitoring

Diabetic Medicine, 1991
The use of a reagent strip and reflectance meter for the bedside measurement of 3‐hydroxybutyrate during the clinical management of diabetic ketoacidosis is described. Comparison of this method with a laboratory enzymatic assay shows good correlation (r = 0.97, p < 0.05). Initial use in acute ketoacidosis suggests that knowledge of hourly changes in
M O, McBride, M, Smye, G S, Nesbitt, D R, Hadden   +3 more
openaire   +2 more sources