Ketone bodies as signaling metabolites [PDF]
Trends in Endocrinology & Metabolism, 2014 Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also signals via extracellular receptors and acts as an endogenous inhibitor of histone deacetylases (HDACs). These recent findings support a model in which βOHB functions to link
John C, Newman, Eric, Verdin
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Ketone body β-hydroxybutyrate (BHB) preserves mitochondrial bioenergetics
Scientific Reports, 2023 The ketogenic diet is an emerging therapeutic approach for refractory epilepsy, as well as certain rare and neurodegenerative disorders. The main ketone body, β-hydroxybutyrate (BHB), is the primary energy substrate endogenously produced in a ketogenic ...
I. Llorente-Folch +4 more
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Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats [PDF]
, 2006 Pregnant Sprague–Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000 ppm) and methylethylketone (MEK; 0, 1000, or 3000 ppm), alone and in combination, by inhalation, for 6 h/day, during days 6–20 of gestation.
Bourges-Abella, Nathalie +6 more
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Regulation of adult stem cell function by ketone bodies
Frontiers in Cell and Developmental Biology, 2023 Adult stem cells play key roles in tissue homeostasis and regeneration. Recent evidence suggests that dietary interventions can significantly impact adult stem cell function. Some of these effects depend on ketone bodies. Adult stem cells could therefore
Ole Emil Andersen +5 more
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Ketone Bodies, Potential Therapeutic Uses [PDF]
IUBMB Life, 2001 AbstractKetosis, meaning elevation of D‐ β‐hydroxybutyrate ( R ‐3‐hydroxybutyrate) and acetoacetate, has been central to starving man's survival by providing nonglucose substrate to his evolutionarily hypertrophied brain, sparing muscle from destruction for glucose synthesis.
R L, Veech +4 more
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Determination of 14C radioactivity in ketone bodies: a new, simplified method and its validation.
Journal of Lipid Research, 1980 A rapid and reproducible method for the assay of 14C radioactivity in ketone bodies is described, based on the heat lability of acetoacetate and the ability of beta-hydroxybutyrate to quantitatively bind to and elute from an ion exchange resin. Potential
J M Miles +3 more
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PLoS Biology, 2023 In humans, mutations in D-2-hydroxyglutarate (D-2HG) dehydrogenase (D2HGDH) result in D-2HG accumulation, delayed development, seizures, and ataxia. While the mechanisms of 2HG-associated diseases have been studied extensively, the endogenous metabolism ...
Olga Ponomarova +10 more
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Anti-oxidant and anti-inflammatory activity of ketogenic diet. New perspectives for neuroprotection in alzheimer’s disease [PDF]
, 2018 The ketogenic diet, originally developed for the treatment of epilepsy in non-responder children, is spreading to be used in the treatment of many diseases, including Alzheimer’s disease.
Bonucci, Alessio +4 more
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Scientific Opinion on Flavouring Group Evaluation 7, Revision 5 (FGE.07Rev5) : saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched‐chain carboxylic acids from chemical group 5 [PDF]
, 2017 Acknowledgements: The Panel wishes to thank the members of the Working Group on Flavourings: Ulla Beckman Sundh, Leon Brimer, Karl-Heinz Engel, Paul Fowler, Rainer Gürtler, Trine Husøy, Wim Mennes and Gerard Mulder for the preparatory work on this ...
Anastassiadou, Maria +25 more
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A case of persistent severe abdominal pain caused by type 1 diabetic ketoacidosis
Journal of Clinical and Translational Endocrinology Case Reports, 2021 We herein report a case of a 31-year-old man suffered from type 1 diabetic ketoacidosis (DKA) complicated with severe abdominal pain. On admission, his blood glucose content was 17.58 mmol/L, pH value of blood was 7.286, urine ketone body content was 3 ...
Qian Xu +4 more
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