Results 41 to 50 of about 52,379 (262)

Characteristics of Cardiac Ketone Body Metabolism Throughout the Life Cycle

Cardiovascular Therapeutics
Ketone bodies can serve as energy substrates for the heart and perform important molecular signal transduction functions. In recent years, the therapeutic potential of ketone bodies has become a research hotspot in the field of cardiovascular diseases ...
Lei Li, Xiaojian Song, Xiurui Ma, Yanwu Xu   +3 more
doaj   +1 more source

Genetic Relationship of Body Energy and Blood Metabolites with Reproduction in Holstein Cows [PDF]

, 2008
Body condition score (BCS), energy content (EC), cumulative effective energy balance (CEEB), and blood serum concentrations of glucose, beta-hydroxybutyrate (BHBA), and nonesterified fatty acids ( NEFA) were measured throughout first lactation in 497 ...
A. Tsiaras, Banos, Banos, Berry, Brotherstone, Bruss, Butler, Clark, D. Zygoyiannis, de Vries, Dechow, Edmonson, Ferguson, Fox, G. Arsenos, G. Banos, G. Oikonomou, G.E. Valergakis, Gilmour, Hayhurst, Herdt, Holtenius, Lucy, Markusfeld, Moallem, Patton, Pryce, Pryce, Pryce, Rabiee, Reist, Reist, Stevenson, Suriyasathaporn, Veerkamp, Veerkamp, Wall, Walsh, Wathes, Westwood, Whitaker   +40 more
core   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

The Role of Exogenous Ketones in Road Cycling: Evidence, Mechanisms, and Performance Claims

Physiologia
Background: Ketone body supplementation has emerged as a potential ergogenic aid in cycling. Exogenous ketones, primarily in the form of beta-hydroxybutyrate, offer an alternative fuel source, bypassing the need for strict ketogenic diets.
Sebastian Sitko
doaj   +1 more source

Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury

BMC Neuroscience, 2010
Background The administration of the ketone bodies hydroxybutyrate and acetoacetate is known to exert a protective effect against metabolic disorders associated with cerebral pathologies.
de Reggi Max, Nieoullon André, Khrestchatisky Michel, Abou-Hamdan Mhamad, Cornille Emilie, Gharib Bouchra   +5 more
doaj   +1 more source

Ketone body 3-hydroxybutyrate as a biomarker of aggression

Scientific Reports, 2021
Human aggression is a complex behaviour, the biological underpinnings of which remain poorly known. To gain insights into aggression biology, we studied relationships with aggression of 11 low-molecular-weight metabolites (amino acids, ketone bodies ...
A. M. Whipp, E. Vuoksimaa, T. Korhonen, R. Pool, A. But, L. Ligthart, F. A. Hagenbeek, M. Bartels, L. H. Bogl, L. Pulkkinen, R. J. Rose, D. I. Boomsma, J. Kaprio   +12 more
doaj   +1 more source

Gram‐Scale Production of Iron Oxide Rubik‐Cube Nanoparticles: New Tools for the Clinical Translation of Magnetic Hyperthermia and Magnetic Particle Imaging

Advanced Functional Materials, EarlyView.
This work reports the first gram‐scale solvothermal synthesis of ‘Rubik's cube’ nanoparticles—cubic, dendritic multicore structures with tuneable sizes and exceptional magnetic heating performance. Featuring iron oxide single‐domain character, with low coercivity fields, high magnetization, and strong MPI signals, they enable viscosity‐independent ...
Giusy M. R. Rizzo, Niccolò Silvestri, Nabila Jarmouni, Helena Gavilán, Hamza Yakubu, Daniel Arenas‐Esteban, Sara Bals, Paola Parlanti, Mauro Gemmi, Ross Clark Prado, Anna Cristina S. Samia, Verónica Salgueiriño, Teresa Pellegrino   +12 more
wiley   +1 more source

Clinical Nutritional Study of Minimum Protein and Caloric Requirements for Man. Annual Report, Sep. 1965 - Sep. 1966 [PDF]

, 1966
Minimum protein and caloric requirements for prolonged manned spaceflight and space ...
Calloway, D. H., Margen, S.
core   +1 more source

In vivo investigation of hyperpolarized [1,3-13C2]acetoacetate as a metabolic probe in normal brain and in glioma. [PDF]

, 2019
Dysregulation in NAD+/NADH levels is associated with increased cell division and elevated levels of reactive oxygen species in rapidly proliferating cancer cells.
Batsios, Georgios, Gillespie, Anne Marie, Le Page, Lydia M, Najac, Chloé, Radoul, Marina, Ronen, Sabrina M, Subramani, Elavarasan, Viswanath, Pavithra   +7 more
core   +3 more sources

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source