Results 81 to 90 of about 52,379 (262)

Nutritional ketosis delays the onset of isoflurane induced anesthesia

BMC Anesthesiology, 2018
Background Ketogenic diet (KD) and exogenous ketone supplements can evoke sustained ketosis, which may modulate sleep and sleep-like effects. However, no studies have been published examining the effect of ketosis on the onset of general isoflurane ...
Csilla Ari, Zsolt Kovács, Cem Murdun, Andrew P. Koutnik, Craig R. Goldhagen, Christopher Rogers, David Diamond, Dominic P. D’Agostino   +7 more
doaj   +1 more source

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

Advanced Science, EarlyView.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou, Wan Fu, Shizuo Liu, Zili Zhang, Hanyan Luo, Qing Zhong   +5 more
wiley   +1 more source

Chemical Proteomics Identifies Ketogenesis‐Mediated Cysteine Modifications Regulating Redox Function

Angewandte Chemie, EarlyView.
Herein, we report ketone body induce cysteine modifications beyond lysine acylation, as revealed by integrating chemical proteomics with open‐search methods. Among the modifications, cysteine crotonation (Ccr) was chemically validated by endogenous peptide‐based co‐elution assays.
Yuan‐Fei Zhou, Ling Zhang, Zhuoyi L. Niu, Xin Wang, Alejandro Storper, Ryan Hunt, Yingming Zhao, Nima Sharifi, Zhipeng A. Wang   +8 more
wiley   +2 more sources

Metabolic Effects of the Very-Low-Carbohydrate Diets: Misunderstood "Villains" of Human Metabolism

Journal of the International Society of Sports Nutrition, 2004
During very low carbohydrate intake, the regulated and controlled production of ketone bodies causes a harmless physiological state known as dietary ketosis. Ketone bodies flow from the liver to extra-hepatic tissues (e.g., brain) for use as a fuel; this
Manninen Anssi H
doaj   +1 more source

Designing all-graphene nanojunctions by covalent functionalization

, 2011
We investigated theoretically the effect of covalent edge functionalization, with organic functional groups, on the electronic properties of graphene nanostructures and nano-junctions.
Abe S., Alice Ruini, Barone V., Bekyarova E., Burghard M., Cai J., Caldas M. J., Campos L. C., Cano-Márquez A. G., Castro Neto A. H., Caterina Cocchi, Chen W., Chen Z., Datta S. S., Deborah Prezzi, Dewar M. J. S., Dávila L. Y. A., Elisa Molinari, Farmer D. B., Farmer D. B., Geim A., Han M. Y., Hantal G., Jia X., Jiao L., Kosynkin D. V., Lair S., Li X., Loh K., Lohmann T., Lopez-Bezanilla A., Lu Y. H., Marilia J. Caldas, Nakada K., Novoselov K. S., Ponomarenko L., Prezzi D., Prezzi D., Qian H., Roothaan C. C. J., Sevinçli H., Sinitskii A., Soldano C., Son Y.-W., Sun J. T., Tachikawa H., Venkataraman L., Wang X., Wang X., Wang X., Wetmore S. D., Xia F., Yang L., Yang L., Yang X., Zhang Y.-H.   +55 more
core   +1 more source

Low-carbohydrate diets affect energy balance and fuel homeostasis differentially in lean and obese rats [PDF]

, 2006
In parallel with increased prevalence of overweight people in affluent societies are individuals trying to lose weight, often using low-carbohydrate diets.
Dijk, G. van,, Morens, C.,, Scheurink, A.J.W.,, Sirot, V.,   +3 more
core   +4 more sources

Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion

Advanced Science, EarlyView.
This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab, Rasika Daware, Marcelo A. Szymanski de Toledo, Oskar Weber, Dimitris Kapsokalyvas, Twan Lammers, Horst Fischer, Federica De Lorenzi, Fabian Kiessling   +8 more
wiley   +1 more source

Alkoxysulfonium Salts Unlock Access to New Aryl Sulfonium Salts for Cross‐Coupling

Angewandte Chemie, EarlyView.
Hard‐to‐access (hetero)aryl sulfonium salts are prepared using stable methoxysulfonium salts in combination with the magnesiation of (hetero)aryl bromides. The approach allows access to aryl sulfonium salts bearing electron‐deficient (hetero)aryl rings, or electron‐rich aryl motifs in which the sulfonium motif resides at an alternative position on the ...
Rachel E. Brown, Navpreet Kaur, Anne‐Chloe M. A. Nassoy, Ciro Romano, David J. Procter   +4 more
wiley   +2 more sources

SGLT2 Inhibitors Play a Salutary Role in Heart Failure via Modulation of the Mitochondrial Function

Frontiers in Cardiovascular Medicine, 2020
Three cardiovascular outcome trials of sodium glucose cotransporter 2 (SGLT2) inhibitors, including the EMPA-REG OUTCOME trial, CANVAS Program, and DECLARE TIMI 58 trial, revealed that SGLT2 inhibitors were superior to a matching placebo in reducing ...
Yasuhiro Maejima
doaj   +1 more source

Myocardial Ischemia Suppresses Ketone Body Utilization

Journal of the American College of Cardiology, 2019
Ketone bodies (acetoacetate, acetone, and β-hydroxybutyrate [βOHB]) are metabolites that are well known as alternative energy sources [(1)][1]. Recent studies have reported that sodium glucose cotransporter-2 (SGLT2) inhibitors increased ketone body concentrations along with a significant ...
Yuichiro, Arima, Yasuhiro, Izumiya, Toshifumi, Ishida, Seiji, Takashio, Masanobu, Ishii, Daisuke, Sueta, Koichiro, Fujisue, Kenji, Sakamoto, Koichi, Kaikita, Kenichi, Tsujita   +9 more
openaire   +2 more sources